Prevention ofhepatocellularcarcinoma development through inhibition of AP-1 by EGCG
| Project/Area Number |
22591428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
FUJII Tsutomu 名古屋大学, 医学部附属病院, 助教 (60566967)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hiroyuki 名古屋大学, 大学院・医学系研究科, 講師 (20437007)
NOMOTO Shuji 名古屋大学, 医学部附属病院, 病院講師 (40300967)
KASUYA Hideki 名古屋大学, 大学院・医学系研究科, 准教授 (00402636)
TAKEDA Shin 名古屋大学, 大学院・医学系研究科, 准教授 (20314015)
NAKAO Akimasa 名古屋大学, 大学院・医学系研究科, 教授 (70167542)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | EGCG / AP-1 / EGF / 肝細胞癌 |
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| Research Abstract |
In the liver cancer tissue of EGF transgenic mice, the increased expression of c-jun and activity of AP-1 were shown to increase. In addition, the intraabdominal administration of EGCG suppressed hepatocarcinogenesis. These in vivoresults were similar to in vitroones that we revealed previously. Furthermore, when we examined the signaling pathways of human liver cancer tissue, the recurrence-free survival in patients with higher expression of c-Jun was significantly lower than that in patients with lower expression of c-jun.
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Report
(4 results)
Research Products
(7 results)
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[Presentation] Epithelial to Mesenchymal Transition (EMT) in Pancreatic Cancer2012
Author(s)
Tsutomu Fujii, Suguru Yamada, Masaya Suenaga, Norio Okumura, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Shin Takeda, Yasuhiro Kodera
Organizer
The Joint 43rd Meeting of the American Pancreatic Association and the 17th Meeting of the International Association of Pancreatology
Place of Presentation
Miami, Florida
Year and Date
2012-11-02
Related Report
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[Presentation] EGFR Inhibition Prevents Cirrhosis and Hepatocellular Carcinoma2011
Author(s)
Bryan C. Fuchs1, Yujin Hoshida, Tsutomu Fujii, Suguru Yamada, Gregory Y. Lauwers, Christopher M. McGinn, Lan Wei, Toshihiko Kuroda, Michael Lanuti, Supriya Gupta, Andrew Crenshaw, Robert Onofrio, Bradley Taylor, Wendy Winckler, Todd R. Golub, Kenneth K. Tanabe
Organizer
AASLD (The American Association for the Study of Liver Diseases) 62nd Annual Meeting and Postgraduate CourceThe - Liver Meeting 2011
Place of Presentation
San Francisco, California
Year and Date
2011-11-08
Related Report
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