| Project/Area Number |
22591428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
FUJII Tsutomu 名古屋大学, 医学部附属病院, 助教 (60566967)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hiroyuki 名古屋大学, 大学院・医学系研究科, 講師 (20437007)
NOMOTO Shuji 名古屋大学, 医学部附属病院, 病院講師 (40300967)
KASUYA Hideki 名古屋大学, 大学院・医学系研究科, 准教授 (00402636)
TAKEDA Shin 名古屋大学, 大学院・医学系研究科, 准教授 (20314015)
NAKAO Akimasa 名古屋大学, 大学院・医学系研究科, 教授 (70167542)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | EGCG / AP-1 / EGF / 肝細胞癌 |
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| Research Abstract |
In the liver cancer tissue of EGF transgenic mice, the increased expression of c-jun and activity of AP-1 were shown to increase. In addition, the intraabdominal administration of EGCG suppressed hepatocarcinogenesis. These in vivoresults were similar to in vitroones that we revealed previously. Furthermore, when we examined the signaling pathways of human liver cancer tissue, the recurrence-free survival in patients with higher expression of c-Jun was significantly lower than that in patients with lower expression of c-jun.
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