| Project/Area Number |
22591429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
IMAI Tsuneo 名古屋大学, 医学部附属病院, 講師 (80252245)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Akimasa 名古屋大学, 大学院・医学系研究科, 教授 (70167542)
KOBAYASHI Takeshi 中部大学, 応用生物学部, 教授 (10043324)
KIKUMORI Toyone 名古屋大学, 医学部附属病院, 講師 (90402635)
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| Research Collaborator |
AKIYMA Masashi 名古屋大学, 大学院・医学系研究科, 教授 (60222551)
YOKOTA Kenji 名古屋大学, 大学院・医学系研究科, 助教 (20456651)
NISHIDA Yoshihiro 名古屋大学, 大学院・医学系研究科, 准教授 (50332698)
FUJIMOTO Yasushi 名古屋大学, 大学院・医学系研究科, 講師 (40344337)
YAMAMOTO Noriyuki 名古屋大学, 大学院・医学系研究科, 助教 (60378156)
FURUE Hiroki 名古屋大学, 医学部附属病院, 助教 (40567012)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | マグネトリポソーム / 温熱療法 / 陽性荷電 / 交番磁場照射 / 乳癌 / 甲状腺癌 / 第I相臨床試験 / 温熱免疫療法 / リポソーム / マグネタイト |
|---|
| Research Abstract |
A phase I study of hyperthermia using magnetic cationic liposome (MCL) and alternate magnetic field was conducted. Patients with refractory breast cancer, thyroid cancer, soft tissue sarcoma, and tongue cancer were enrolled. MCL (5mg/body) was locally injected to the recurrence site and alternate magnetic field was irradiated for 30 minutes to keep the temperature of the skin at 43 degree Celsius in the first 3 patients. MCL (50mg/body) was given and hyperthermia was conducted in the same manner in the next 3 patients. No adverse event was observed in all patients. The pathological examination 2 weeks after hyperthermia showed various local effects such as tumor necrosis, but there was no systemic benefit.
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