Study of growth factors in intestinal failure

Research Project

Project/Area Number	22591432
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General surgery
Research Institution	Osaka University
Principal Investigator	WASA Masafumi 大阪大学, 医学系研究科, 准教授 (10240467)
Co-Investigator(Kenkyū-buntansha)	FUKUZAWA Masahiro 大阪大学, 医学系研究科, 准教授 (60165272) SOH Hideki 大阪大学, 医学系研究科, 助教 (00457011) UEHARA Shuichiro 大阪大学, 医学系研究科, 助教 (00448060)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	腸管不全 / 再生促進因子 / グルタミン / 腸管障害 / 抗がん剤 / アポトーシス / 腸管上皮細胞 / アミノ酸トランスポート
Research Abstract	The purpose of the present study was to examine the effect of glutamine on mucosal damage induced by cyclophosphamide in a rat and elucidate the mechanism for its protective effects. Glutamine prevents intestinal mucosal injury induced by cyclophosphamide by the mechanism of increased glutathione, decreased apoptosis and increased proliferation of intestinal epithelial cells.