Study of growth factors in intestinal failure
Project/Area Number |
22591432
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
|
Research Institution | Osaka University |
Principal Investigator |
WASA Masafumi 大阪大学, 医学系研究科, 准教授 (10240467)
|
Co-Investigator(Kenkyū-buntansha) |
FUKUZAWA Masahiro 大阪大学, 医学系研究科, 准教授 (60165272)
SOH Hideki 大阪大学, 医学系研究科, 助教 (00457011)
UEHARA Shuichiro 大阪大学, 医学系研究科, 助教 (00448060)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 腸管不全 / 再生促進因子 / グルタミン / 腸管障害 / 抗がん剤 / アポトーシス / 腸管上皮細胞 / アミノ酸トランスポート |
Research Abstract |
The purpose of the present study was to examine the effect of glutamine on mucosal damage induced by cyclophosphamide in a rat and elucidate the mechanism for its protective effects. Glutamine prevents intestinal mucosal injury induced by cyclophosphamide by the mechanism of increased glutathione, decreased apoptosis and increased proliferation of intestinal epithelial cells.
|
Report
(4 results)
Research Products
(4 results)