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Analysis of the new joint protein receptor of PSTI

Research Project

Project/Area Number 22591437
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKumamoto University

Principal Investigator

OZAKI Nobuyuki  熊本大学, 医学部附属病院, 非常勤診療医師 (40551255)

Co-Investigator(Kenkyū-buntansha) BABA Hideo  熊本大学, 大学院・生命科学研究部, 教授 (20240905)
CHIKAMOTO Akira  熊本大学, 医学部附属病院, 講師 (10419640)
ISHIKO Takatoshi  熊本大学, 医学部附属病院, 准教授 (00343351)
TAKAMORI Hiroshi  熊本大学, 医学部附属病院, 非常勤診療医師 (90363514)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsPSTI / SPINK1 / TATI / 膵癌 / 慢性膵炎 / EGFR / 大腸癌
Research Abstract

We aimed for the treatment strategy which assumed pancreatic cancer and elucidation ofa new receptor with PST. About a new receptor, we were not able to identify an effectivereceptor except EGFR. So, we established chronic pancreatitis model mouse of two kindsof onset mechanism by controlling PSTI gene expression using gene change technology andexamined activation of a pancreas stellate cell concerned with pancreatic fibrosis, Krasgene, EGFR family gene, expression of INK4a gene. We showed an abnormal increase withKi67 positive acini cell which formed duct -like structure. Expression of a Kras gene,an EGFR family gene was already present in conditions of chronic pancreatitis, and itwas suggested that it was a transition stage to precancerosis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2013 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Prediction of operative morbidityafter pancreatic resection2013

    • Author(s)
      Hashimoto D,Takamori H,Ozaki N,TanakaH,Hirota M,Baba H
    • Journal Title

      Hepato-Gastroenterology

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serine protease inhibitor Kazaltype 1 and epidermal growth factorreceptor are expressed in pancreatictubular adenocarcinoma, intraductalpapillary mucinous neoplasm, andpancreatic intraepithelialneoplasia2013

    • Author(s)
      Ozaki N, Ohmuraya M, Ida S, HashimotoD, Ikuta Y, Chikamoto A, Hirota M, BabaH
    • Journal Title

      J Gastroenteol (Published Online)

      Volume: Publiosh Online Issue: 6 Pages: 620-627

    • DOI

      10.1007/s00534-012-0587-6

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大腸癌発癌におけるSPINK1の発現と意義2011

    • Author(s)
      井田智
    • Journal Title

      消化器内科

      Volume: 53 Pages: 627-631

    • Related Report
      2011 Annual Research Report
  • [Presentation] 膵発癌における Serine proteaseinhibitor Kazal type 1(SPINK1) とEpdermal growth factorreceptor (EGFR)の発現とその意義2012

    • Author(s)
      尾崎宣之、近本 亮、生田義明、橋本大輔、渡邊雅之、別府 透、馬場秀夫
    • Organizer
      第25回日本消化器癌発生学会
    • Place of Presentation
      徳島県 ルネッサンスリゾートナルト
    • Year and Date
      2012-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性膵炎モデルマウスでは癌関連遺伝子の異常が引き起こされる2012

    • Author(s)
      大村谷昌樹、能登原憲司、荒木喜美、馬場秀夫、山村研一
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道 札幌市教育文化会館
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵発癌におけるSerine protease inhibitor Kazal type 1(SPINK1) とEpdermal growth factorreceptor (EGFR) の発現とその意義.2012

    • Author(s)
      尾崎宣之
    • Organizer
      第23回日本消化器癌発生学会
    • Place of Presentation
      ルネッサンスリゾートナルト 徳島県
    • Related Report
      2012 Annual Research Report
  • [Presentation] 膵癌切除症例における性差からみた臨床病理学的特徴2011

    • Author(s)
      高森啓史
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋名古屋国際会議場
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 転移性膵腫瘍の臨床病理学的特徴2011

    • Author(s)
      黒木秀幸
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋名古屋国際会議場
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 喫煙が膵癌周術期に与える影響2011

    • Author(s)
      堀野敬
    • Organizer
      第42回日本膵臓学会大会
    • Place of Presentation
      青森ホテルニューキャッスル
    • Year and Date
      2011-07-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 浸潤性膵管癌に対する治療戦略2011

    • Author(s)
      高森啓史
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋名古屋国際会議場
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Serine protease inhibitor Kazal type 1 promote a carcinogenesis of the colon2011

    • Author(s)
      Ida S
    • Organizer
      AACR102nd Annual Meeting 2011
    • Place of Presentation
      the Orange County Convention Center in Orlando, Florida
    • Year and Date
      2011-04-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膵分泌性トリプシンインヒビター (PST1)は炎症性陽疾患関連発癌・進展に寄与する2011

    • Author(s)
      井田 智、大村谷昌樹、岩槻政晃、長井洋平、岩上志朗、宮本裕士、林 尚子、渡邊雅之、馬場秀夫
    • Organizer
      第74回大腸癌研究会
    • Place of Presentation
      福岡県 アクロス福岡
    • Year and Date
      2011-01-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵内分泌腫瘍に対する超音波内視鏡下穿刺吸引生検(EUS-FNA)の有用性2011

    • Author(s)
      中原、 修、 高森啓史、 堀野 敬、 近本 亮、田中 洋、 古橋 聡、 阿部真也、 別府 透、馬場秀夫
    • Organizer
      第6回 NET Work Japan
    • Place of Presentation
      東京都 品川プリンスホテル
    • Year and Date
      2011-01-22
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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