• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Novel biomarker for the prediction of tamoxifen treatment in ER positive breast cancer

Research Project

Project/Area Number 22591442
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKeio University

Principal Investigator

JINNO Hiromitsu  慶應義塾大学, 医学部, 講師 (20216261)

Co-Investigator(Kenkyū-buntansha) HAYASHIDA Tetsu  慶應義塾大学, 医学部, 助教 (80327543)
TAKAHASHI Maiko  慶應義塾大学, 医学部, 助教 (50348661)
SAKATA Michio  慶應義塾大学, 医学部, 助教 (60235158)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsBTG2 / 乳癌 / 内分泌療法 / 薬剤感受性 / タモキシフェン
Research Abstract

Based on previous results, we analyzed if BTG2 expression affects the sensitivity against tamoxifen. Tetracycline-inducible BTG2 expression model in MCF7 was developed to assess the cytotoxicity by tamoxifen treatment in vitro and in vivo. Tumor growth ra

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] HOXB9 Expression Promoting Tumor Cell Proliferation and Angiogenesis Is Associated with Clinical Outcomes in Breast Cancer Patients2012

    • Author(s)
      Seki H, Hayashida T, Jinno H, Hirose S, Sakata M, Takahashi M, Maheswaran S, Mukai M, Kitagawa Y
    • Journal Title

      Annals of Surgical Oncology

      Volume: (E-pub ahead of print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Loss of BTG2 expression in breast cancer predicts tamoxifen resistance2011

    • Author(s)
      高橋 麻衣子
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Loss of BTG2 expression in breast cancer predicts tamoxifen resistance2011

    • Author(s)
      Maiko Takahashi, Tetsu Hayashida, Hiromitsu Jinno, Yuko Kitagawa
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Loss of B-cell translocationgene 2 in estrogen receptor-positive breast cancer and tamoxifen resistance2011

    • Author(s)
      林田 哲
    • Organizer
      ASCO Breast cancer symposium
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2011-09-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Loss of B-cell translocation gene 2 in estrogen receptoror-positive breast cancer and tamoxifen resistance2011

    • Author(s)
      Tetsu Hayashida, Hiromitsu Jinno, Maiko Takahashi, Yuko Kitagawa
    • Organizer
      ASCO Breast cancer symposium
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Loss of BTG2 expression in breast cancer predicts tamoxifen resistance2010

    • Author(s)
      高橋 麻衣子
    • Organizer
      San Antonio Breast Cancer Symposium
    • Place of Presentation
      米国 サンアントニオ
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Loss of BTG2 expression in breast cancer predicts tamoxifen resistance2010

    • Author(s)
      高橋麻衣子
    • Organizer
      San Antonio Breast Cancer Symposium
    • Place of Presentation
      米国 San Antonio
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床応用を目指す新しい内分泌療法の奏効を規定する因子の検討2010

    • Author(s)
      林田 哲
    • Organizer
      日本乳癌学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-25
    • Related Report
      2012 Final Research Report 2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi