Novel biomarker for the prediction of tamoxifen treatment in ER positive breast cancer

• Project/Area Number: 22591442
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Keio University
• Principal Investigator: JINNO Hiromitsu 慶應義塾大学, 医学部, 講師 (20216261)
• Co-Investigator(Kenkyū-buntansha): HAYASHIDA Tetsu 慶應義塾大学, 医学部, 助教 (80327543) ; TAKAHASHI Maiko 慶應義塾大学, 医学部, 助教 (50348661) ; SAKATA Michio 慶應義塾大学, 医学部, 助教 (60235158)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: BTG2 / 乳癌 / 内分泌療法 / 薬剤感受性 / タモキシフェン

Research Abstract

Based on previous results, we analyzed if BTG2 expression affects the sensitivity against tamoxifen. Tetracycline-inducible BTG2 expression model in MCF7 was developed to assess the cytotoxicity by tamoxifen treatment in vitro and in vivo. Tumor growth ra

Research Products

• [Journal Article] HOXB9 Expression Promoting Tumor Cell Proliferation and Angiogenesis Is Associated with Clinical Outcomes in Breast Cancer Patients (2012)
  • Author(s): Seki H, Hayashida T, Jinno H, Hirose S, Sakata M, Takahashi M, Maheswaran S, Mukai M, Kitagawa Y
  • Journal Title: Annals of Surgical Oncology Volume: (E-pub ahead of print)
  • Peer Reviewed
• [Presentation] Loss of BTG2 expression in breast cancer predicts tamoxifen resistance (2011)
  • Author(s): 高橋 麻衣子
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] Loss of BTG2 expression in breast cancer predicts tamoxifen resistance (2011)
  • Author(s): Maiko Takahashi, Tetsu Hayashida, Hiromitsu Jinno, Yuko Kitagawa
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-10-05
• [Presentation] Loss of B-cell translocationgene 2 in estrogen receptor-positive breast cancer and tamoxifen resistance (2011)
  • Author(s): 林田 哲
  • Organizer: ASCO Breast cancer symposium
  • Place of Presentation: 米国サンフランシスコ
  • Year and Date: 2011-09-09
• [Presentation] Loss of B-cell translocation gene 2 in estrogen receptoror-positive breast cancer and tamoxifen resistance (2011)
  • Author(s): Tetsu Hayashida, Hiromitsu Jinno, Maiko Takahashi, Yuko Kitagawa
  • Organizer: ASCO Breast cancer symposium
  • Place of Presentation: 米国サンフランシスコ
  • Year and Date: 2011-09-09
• [Presentation] Loss of BTG2 expression in breast cancer predicts tamoxifen resistance (2010)
  • Author(s): 高橋 麻衣子
  • Organizer: San Antonio Breast Cancer Symposium
  • Place of Presentation: 米国 サンアントニオ
  • Year and Date: 2010-12-10
• [Presentation] Loss of BTG2 expression in breast cancer predicts tamoxifen resistance (2010)
  • Author(s): 高橋麻衣子
  • Organizer: San Antonio Breast Cancer Symposium
  • Place of Presentation: 米国 San Antonio
  • Year and Date: 2010-12-10
• [Presentation] 臨床応用を目指す新しい内分泌療法の奏効を規定する因子の検討 (2010)
  • Author(s): 林田 哲
  • Organizer: 日本乳癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-25