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Utility of Real-time Virtual Sonography (RVS), anew breast imaging method for coordinating sonography with an MRIusing an image fusion technique

Research Project

Project/Area Number 22591445
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionAichi Medical University

Principal Investigator

NAKANO Shogo  愛知医科大学, 医学部, 教授 (20351108)

Co-Investigator(Kenkyū-buntansha) FUJII Kimihito  愛知医科大学, 医学部, 講師 (00524331)
YOSHIDA Miwa  愛知医科大学, 医学部, 助教 (30556098)
KOUSAKA Junko  愛知医科大学, 医学部, 助教 (50440748)
FUKUTOMI Takashi  愛知医科大学, 医学部, 教授 (30165302)
ISHIGUCHI Tsuneo  愛知医科大学, 医学部, 教授 (70115525)
萬谷 京子  愛知医科大学, 医学部, 講師 (90297359)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords乳癌 / MRI / US / RVS / 生検 / 超音波 / 画像融合技術 / 乳腺画像診断 / 磁気ナビゲーション
Research Abstract

We have developed real-time virtual sonography (RVS), a method for coordinating sonography with an MRI system using an image fusion technique. Since 2005, we have applied this method to sonographic evaluation of MRI-detected lesions of the breast. We reported previously that in 2009, 98% of MRI enhanced index mass and 83% of MRI-detected lesions were identified using RVS (Nakano, et al. Jpn J Clinic Oncol 2009). The aims of this study were (1) to evaluate the targeting accuracy of RVS in sonographic identification of enhancing lesions detected by breast MRI, and (2) to verify the utility of second-look sonography using RVS. (1) We analyzed the positioning error, i.e., the distance from the actual sonographic position to the expected MRI position, in three dimensions. The meanpositioning errors for the transverse and sagittal planes and the depth from the skin were 7.7, 6.9, and 2.8 mm, respectively. The overall mean three-dimensional positioning error was 12.0 mm (Nakano, et al. Ultrasound Med Biol 2012). (2) We analyzed the correlations between lesion detection rates on second-look sonography using conventional B-mode or RVS. Among 67 lesions (24 malignant and 43 benign), the detection rate of conventional B-mode was 27% (18/67); RVS increased these rates signi〓cantly, to 90 % (60/67) (p <0.001) (Nakano, et al. Breast Cancer Res Treat 2012). Our results suggest that RVS has good targeting accuracy in a direct comparison of a sonographic image with MRI results, and the additional use of RVS on second-look sonography signi〓cantly increases the sonographic detection rate of MRI-detected lesions without operator dependence. Webelieve that RVS represents a promising new modality for breast imaging.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (33 results)

All 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 2 results) Presentation (11 results) Book (7 results) Remarks (1 results)

  • [Journal Article] Real-time virtual sonography, acoordinated sonography and MRI system that uses magnetic navigation, improvesthe sonographic identification ofenhancing lesions on breast MRI.2012

    • Author(s)
      Nakano S, Yoshida M,Ishiguchi T, et al.
    • Journal Title

      Ultrasound Med Biol

      Volume: 38 Pages: 42-49

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impact ofreal-time virtual sonography, a coordinated sonography and MRI systemthat uses an image fusion technique,on thesonographic evaluation of MRI-detected lesions of the breast in second-looksonography.2012

    • Author(s)
      Nakano S, Kousaka J,et al.
    • Journal Title

      Breast Cancer ResTreat

      Volume: 134 Pages: 1179-1188

    • Related Report
      2012 Final Research Report
  • [Journal Article] Real-time virtual sonography, a coordinated sonography and MRI system that uses magnetic navigation, improves the sonographic identification of enhancing lesions on breast MRI.2012

    • Author(s)
      Nakano S
    • Journal Title

      Ultrasound Med Biol

      Volume: 38 Issue: 1 Pages: 42-49

    • DOI

      10.1016/j.ultrasmedbio.2011.10.005

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of real-time virtual sonography, a coordinated sonography and MRI system that uses an image fusion technique,on the sonographic evaluation of MRI-detected lesions of the breast in second-look sonography.2012

    • Author(s)
      Nakano S
    • Journal Title

      Breast Cancer Res Treat

      Volume: 134 Issue: 3 Pages: 1179-1188

    • DOI

      10.1007/s10549-012-2163-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 乳腺second-look USへのreal-time virtual sonography (RVS)の臨床応用2012

    • Author(s)
      中野正吾
    • Journal Title

      日本臨床

      Volume: 70 Pages: 309-316

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 乳腺画像診断におけるreal-time virtual sonography (RVS)の有用性:現状と将来展望2012

    • Author(s)
      中野正吾
    • Journal Title

      日本内分泌・甲状腺外科学会雑誌

      Volume: 29 Pages: 279-283

    • NAID

      130004600579

    • Related Report
      2012 Annual Research Report
  • [Journal Article] A Case of Quadruple Primary Malignanciesincluding Breast, Tongue, Thyroid andOsteosarcoma in a Young Female withoutKaryotype Abnormality Breast Cancer2011

    • Author(s)
      Kousaka J, Fujii K, Nakano S et al.
    • Journal Title

      E pub ahead of print

    • Related Report
      2012 Final Research Report
  • [Journal Article] 乳腺領域におけるReal-time Virutal Sonography(RVS)の実際と役割-second-lookUSへの応用2011

    • Author(s)
      中野正吾、吉田美和ら
    • Journal Title

      映像情報メディカル

      Volume: 43 Pages: 348-55

    • Related Report
      2012 Final Research Report
  • [Journal Article] 進行・再発乳癌に対するS-1(2投1休法)による化学療法経験2011

    • Author(s)
      藤井公人、高阪絢子、中野正吾ら
    • Journal Title

      癌と化学療法

      Volume: 38 Pages: 1467-1470

    • Related Report
      2012 Final Research Report
  • [Journal Article] 乳腺画像診断におけるReal-time Virtual Sonography(RVS)の臨床応用2011

    • Author(s)
      中野正吾
    • Journal Title

      Rad Fan

      Volume: 9 Pages: 32-33

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 乳腺領域におけるReal-time Virtual Sonography (RVS)の実際と役割 ~second-look USへの応用~2011

    • Author(s)
      中野正吾, 他
    • Journal Title

      映像情報メディカル

      Volume: 43巻 Pages: 348-355

    • NAID

      40018787626

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Evaluation ofOncotype DX Recurrence Score as a prognostic factor in Japanese women with estrogen receptor-positive, node-negative primary Stage I or IIA breast cancer.2010

    • Author(s)
      Yorozuya K, Takeuchi T, Yoshida M, Mouri Y, Kousaka J, Fujii K, Nakano S, Fukutomi T, et al (他 4 名).
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 136 Pages: 939-944

    • Related Report
      2012 Final Research Report
  • [Journal Article] Intracystic invasive papillary carcinoma of the male breast with analyses of loss of heterogzygosity on chromosome 16q.2010

    • Author(s)
      Yoshida M, Mouri Y, Sohei Y, Yorozuya K,Fujii K, Kousaka J,Nakano S, Fukutomi T.
    • Journal Title

      Breast Cancer

      Volume: 17 Pages: 146-50

    • Related Report
      2012 Final Research Report
  • [Journal Article] A case of estrogen receptor positive secretorycarcinoma in a 9 -year-old girl withETV6-NTRK3 fusion gene.

    • Author(s)
      Yorozuya K, Nakano S et al.
    • Journal Title

      Jpn J ClinOncol

      Volume: 42 Pages: 208-11

    • Related Report
      2012 Final Research Report
  • [Presentation] Utility of second-look US with Real-time Virtual Sonography (RVS) for MRI-detected lesions of the breast2012

    • Author(s)
      Nakano S
    • Organizer
      European Congress of Radiology (ECR)
    • Place of Presentation
      Vienna
    • Year and Date
      2012-03-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] A new real-time image fusion technique, a coordinated sonography and MRI using magnetic position2012

    • Author(s)
      Nakano S, Fujii K, et al.
    • Organizer
      SABCS
    • Related Report
      2012 Final Research Report
  • [Presentation] A precisioncomparison of breast ultrasound images between different time phases usingimaging fusion technique with magneticposition tracking system.2012

    • Author(s)
      Nakano S, Fujii K, et al.
    • Organizer
      RSNA
    • Related Report
      2012 Final Research Report
  • [Presentation] Fusion of US andFDG/CT image of evaluation ofloco-regional recurrence of breast cancer using real-time virtual sonography (RVS) :first experience2012

    • Author(s)
      Nakano S, Fujii K, et al.
    • Organizer
      ECR
    • Related Report
      2012 Final Research Report
  • [Presentation] Utility of second-look US with real-time virtualsonography (RVS) for MRI-detected lesionsof the breast.2012

    • Author(s)
      Nakano S, Fujii K, et al.
    • Organizer
      ECR
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳腺超音波画像診断における超音波ボリュームデータを用いたReal-time Virtual sonography (US-RVS)の有用性2011

    • Author(s)
      中野正吾
    • Organizer
      日本乳癌検診学会
    • Place of Presentation
      岡山
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 磁気ナビゲーションによる画像融合技術を用いた新たな乳腺画像診断法(プレジデンシャルシンポジウム)2011

    • Author(s)
      中野正吾
    • Organizer
      日本乳癌学会
    • Place of Presentation
      仙台
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impact of Real-time Virtual Sonography, a coordinated sonography and MRI system with magnetic navigation, on the preoperative staging of breast cancer.2011

    • Author(s)
      Nakano, et al.
    • Organizer
      2011 ECR
    • Place of Presentation
      Vienna (Austria)
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁気ナビゲーションによる画像融合技術を用いた新たな乳腺画像診断法2011

    • Author(s)
      中野正吾ら
    • Organizer
      第19回日本乳癌学会学術総会プレデンシャルシンポジウム
    • Related Report
      2012 Final Research Report
  • [Presentation] Utility of targeted sonography using Real-time Virtual Sonography (RVS) for breast lesions that were suspicious on MRI2010

    • Author(s)
      Nakano, et al.
    • Organizer
      2010 SABCS
    • Place of Presentation
      SanAntonio (USA)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] tracking system

    • Organizer
      improves the sonographicidentification of enhancing lesions in breastMRI
    • Related Report
      2012 Final Research Report
  • [Book] 乳腺 second-look US への real-time virtual sonography (RVS)の 臨床応用2012

    • Author(s)
      中野正吾、藤井公人ら
    • Publisher
      日本臨床
    • Related Report
      2012 Final Research Report
  • [Book] マンモグラフィ読影トレーニング2012

    • Author(s)
      福富隆志、中野正吾ら
    • Publisher
      中外医学社(東京)
    • Related Report
      2012 Final Research Report
  • [Book] マンモグラフィ読影トレーニング(第2版)2012

    • Author(s)
      中野正吾
    • Total Pages
      210
    • Publisher
      中外医学社
    • Related Report
      2011 Annual Research Report
  • [Book] 乳癌診療実践マニュアル2010

    • Author(s)
      福富隆志、中野正吾、高阪絢子、毛利有佳子、吉田美和、藤井公人、萬谷京子(他6名).
    • Publisher
      メジカルビュー社(東京)
    • Related Report
      2012 Final Research Report
  • [Book] 乳房超音波診断アトラス2010

    • Author(s)
      福富隆志、藤井公人、高阪絢子、中野正吾、萬谷京子、吉田美和、毛利有佳子.
    • Publisher
      中外医学社(東京)
    • Related Report
      2012 Final Research Report
  • [Book] 乳癌診療実践マニュアル2010

    • Author(s)
      福富隆志、中野正吾, 他
    • Total Pages
      227
    • Publisher
      メジカルビュー社
    • Related Report
      2010 Annual Research Report
  • [Book] 乳房超音波診断マニュアル2010

    • Author(s)
      福富隆志、中野正吾, 他
    • Total Pages
      103
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.aichi-med-u.ac.jp/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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