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CEACAM-1 promotes lymphangiogenesis and angiogenesis in the inoculated mouse mammary carcinomas.

Research Project

Project/Area Number 22591446
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionOsaka Medical College

Principal Investigator

ITO Yuko  大阪医科大学, 医学部, 講師 (40148432)

Co-Investigator(Kenkyū-buntansha) OTSUKI Yoshinori  大阪医科大学, 医学部, 教授 (50140166)
SHIBATA Masa-aki  大阪保健医療大学, 保健医療部, 教授 (10319543)
MORIMOTO Junji  大阪医科大学, 医学部, 講師 (90145889)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords乳癌 / リンパ管新生 / 血管新生 / CEACAM-1 / Microvesicles / 癌治療 / リンパ行性転移 / マウス乳癌 / リンパ管リプログラミング / 遺伝子導入 / Prox-1 / VEGFR-3 / LYVE-1 / VEGF-C / Podolanin / リン酸化VEGFR-3
Research Abstract

In a highly metastatic mouse mammary carcinoma model which express VEGF-C strongly, CEACAM-1 promots angiogenesis and lymphangiogenesis. I t was suggested that the blood capillaries which expressed CEACAM-1 on the endothelium were remodeled into lymphatic capillaries. Moreover, shedding vesicles containing CEACAM-1 were released from mouse mammary carcinoma cells and may be engulfed byendothelial cells of blood capillaries.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (11 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Microvesicles released from hormone-refractory prostate cancer cells facilitate mouse pre-osteoblast differentiation.2012

    • Author(s)
      Tomohiro Itoh. Yuko Ito. Yoshinori Otsuki. Masashi Ando. Yasuyuki Tsukamasa. Nami Yamada. Tomoki Naoe. Yukihiro Akao.
    • Journal Title

      J Mol Histol

      Volume: Vol.43 Pages: 509-515

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] スプライシング・バリアントである可溶性VEGF受容体2型のマウス乳癌リンパ節転移に対する抑制効果2012

    • Author(s)
      柴田雅朗、J. Ambati,柴田映子、R. JC Albuquerque,森本純司、斯波真理子、藤岡重和、伊藤裕子、大槻勝紀
    • Journal Title

      リンパ学

      Volume: 35巻 Pages: 23-28

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Microvesicle-mediated RNAMolecule Delivery System Using Monocytes/Macrophages.2011

    • Author(s)
      Akao Y, Iio A, Itoh T, Noguchi S, Ito Y, Otsuki Y, Naoe T.
    • Journal Title

      Mol. Ther.

      Volume: 19 Pages: 395-399

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphangiogenesis and Axillary Lymph NodeMetastases Correlated with VEGF-C Expression in Two ImmunocompetentMouseMammary CarcinomaModels.2011

    • Author(s)
      Yuko Ito, Masa-Aki Shibata,Nabil Eid, JunjiMorimoto and Yoshinori Otsuki
    • Journal Title

      International Journal of Breast Cancer

      Volume: 2011 Pages: 1-10

    • DOI

      10.4061/2011/867152

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microvesicle-mediated RNA Molecule Delivery System Using Monocytes/Macrophages.2011

    • Author(s)
      Akao Y, Iio A, Itoh T, Noguchi S, Itoh Y, Ohtsuki Y, Naoe T.
    • Journal Title

      Mol.Ther.

      Volume: 19 Pages: 395-399

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent Median Artery Cadaveric Study and Review of the Literature2011

    • Author(s)
      N.EID, Y.ITO, M.A.SHIBATA., Y.OTSUKI
    • Journal Title

      Clin Anat

      Volume: (On line)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Submandibular gland botulinum toxin injections for drooling : the safe and risky zones.2011

    • Author(s)
      Eid N, Ito Y, Otsuki Y.
    • Journal Title

      Surg Radiol Anat.

      Volume: (On line)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anomalous branching pattern of external carotid artery : Clinical relevance to cervicofacial surgery.2011

    • Author(s)
      Eid N, Ito Y, Otsuki Y.
    • Journal Title

      Clin Anat

      Volume: (On line)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancermodel.2010

    • Author(s)
      Masa-Aki Shibata, Jayakrishna Ambati, Eiko Shibata, Romulo JC Albuquerque, Junji Morimoto, Yuko Ito,Yoshinori Otsuki
    • Journal Title

      BMC Medicine

      Volume: 8 Pages: 69-81

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model2010

    • Author(s)
      Masa-Aki Shibata, Jayakrishna Ambati, Eiko Shibata, Romulo JC Albuquerque, Junji Morimoto, Yuko Ito, Yoshinori Otsuki
    • Journal Title

      BMC Medicine

      Volume: 8 Pages: 69-81

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス乳癌細胞はMicrovesicles(MVs)を放出する.2013

    • Author(s)
      伊藤裕子
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      高松
    • Year and Date
      2013-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス乳癌細胞はMicrovesicles(MVs)を放出する2013

    • Author(s)
      伊藤裕子、ナビル・イード、柴田雅朗、赤尾幸博、大槻勝紀
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      高松
    • Related Report
      2012 Annual Research Report
  • [Presentation] Microvesicles released released from hormone Microvesicles released released from hormone-refractory prostate cancer cells enhance pre-osteoblast differentiation2012

    • Author(s)
      Yuko,I; Nabil,E; Yoshinori,O; Yukihiro,A
    • Organizer
      11th ACU
    • Place of Presentation
      タイ、パタヤ
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス移植乳癌におけるCEACAM-1 の発現とリンパ管新生に対する役割について.2011

    • Author(s)
      伊藤裕子
    • Organizer
      第52回日本組織細胞化学会
    • Place of Presentation
      金沢大学医学部キャンパス
    • Year and Date
      2011-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス移植乳癌におけるCEACAM-1の発現とリンパ管新生に対する役割について2011

    • Author(s)
      伊藤裕子、柴田雅朗、ナビル・イード、大槻勝紀
    • Organizer
      第52回日本組織細胞化学会
    • Place of Presentation
      金沢大学医学部キャンパス
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] CEACAM1 expression and its effects on lymphangiogenesis in the inoculated mice mammary carcinomas.2011

    • Author(s)
      Yuko Ito
    • Organizer
      第116回日本解剖学会・第88回日本生理学会合同総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] CEACAM1 expression and its effects on lymphangiogenesis in the inoculated mice mammary carcinomas.2011

    • Author(s)
      Yuko Ito, Masa-Aki Shibata, Nabil AS Eid, Yoshinori Otsuki
    • Organizer
      第116回日本解剖学会・第88回日本生理学会合同総会
    • Place of Presentation
      パシフィコ横浜(東日本大震災のためJ.Physiol Sciの誌上開催)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] The persistent median artery : Surgically important relationships to proximal and distal branches of median nerve.2011

    • Author(s)
      Nabil AS Eid, Yuko Ito, Yoshinori Otsuki
    • Organizer
      第116回日本解剖学会・第88回日本生理学会合同総会
    • Place of Presentation
      パシフィコ横浜(東日本大震災のためJ.Physiol Sciの誌上開催)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] アポトーシス組織化学解析の基礎と応用2010

    • Author(s)
      伊藤裕子, 大槻勝紀
    • Organizer
      第35回組織細胞化学講習会
    • Place of Presentation
      山梨
    • Year and Date
      2010-08-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of Inducible Nitric Oxide Synthase in DNA Fragmentation in Various Testicular Germ Cells of Ethanol-treated Rats2010

    • Author(s)
      Nabil AS Eid, Yuko Ito, Yoshinori Otsuki
    • Organizer
      5th JAPAN-ASEAN Conference on Men's Health & Aging
    • Place of Presentation
      マレーシア
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 異常な気管支動脈と反回神経を伴った胸管について:解剖体における病例報告2010

    • Author(s)
      ナビル・イード, 伊藤裕子, 大槻勝紀
    • Organizer
      第34回日本リンパ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Book] 組織細胞化学講習会20122012

    • Author(s)
      伊藤裕子、ナビル・イード、大槻勝紀
    • Total Pages
      11
    • Publisher
      日本組織細胞化学会
    • Related Report
      2012 Annual Research Report
  • [Remarks] Bibliographic Database of Osaka Medical College

    • URL

      https://athena.osaka-med.ac.jp/rdb2007/e-search.html

    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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