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Breakthrough of mechanism in micrometastasis using micrometastatic model of esophageal cancer

Research Project

Project/Area Number 22591450
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionGunma University

Principal Investigator

MIYAZAKI Tatsuya  群馬大学, 医学部附属病院, 助教 (70372349)

Co-Investigator(Kenkyū-buntansha) YOKOBORI Takehiko  群馬大学, 医学系研究科, 助教 (60420098)
SAKAI Makoto  群馬大学, 医学部附属病院, 助教 (70420099)
SOHDA Makoto  群馬大学, 医学部附属病院, 助教 (70507326)
KUWANO Hiroyuki  群馬大学, 医学系研究科, 教授 (90186560)
田中 成岳  群馬大学, 医学部, 助教 (30546726)
猪瀬 崇徳  群馬大学, 医学部, 助教 (90609968)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords微小転移 / 腹膜播種 / 癌 / 食道癌 / 同所移植モデル / 同所移植転移モデル微小転移 / 同所移植転移モデル
Outline of Final Research Achievements

We have established mice model to evaluate peritoneal micro metastatic nest, because we could not establish orthotopic transplantation model. We used colon-26-luc cell line and 7-week-old female Balb-c mice. We could visualize micro peritoneal cancer nest as a light of luciferase. We also measured the weight of peritoneal tissue to quantify tumor volume, that related luminescence intensity. We establish the method to evaluate disease progression without sacrifice of mice.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2015 2014 2013 2012 2011

All Journal Article (24 results) (of which Peer Reviewed: 23 results,  Acknowledgement Compliant: 4 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Phase II Study of Docetaxel, Nedaplatin, and 5-Fluorouracil Combined Chemotherapy for Advanced Esophageal Cancer.2015

    • Author(s)
      Miyazaki T, Ojima H, Fukuchi M, Sakai M, Sohda M, Tanaka N, Suzuki S, Ieta K, Saito K, Sano A, Yokobori T, Inose T, Nakajima M, Kato H, Kuwano H.
    • Journal Title

      Ann Surg Oncol.

      Volume: [Epub ahead of print]

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Phase I/II study of docetaxel, cisplatin, and 5-fluorouracil combination chemoradiotherapy in patients with advanced esophageal cancer.2015

    • Author(s)
      Miyazaki T, Sohda M, Tanaka N, Suzuki S, Ieta K, Sakai M, Sano A, Yokobori T, Inose T, Nakajima M, Fukuchi M, Ojima H, Kato H, Kuwano H.
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 75 Issue: 3 Pages: 449-55

    • DOI

      10.1007/s00280-014-2659-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intestinal epithelial culture under an air-liquid interface: a tool for studying human and mouse esophagi.2015

    • Author(s)
      Yokobori T, Suzuki S, Miyazaki T, Sohda M, Sakai M, Tanaka N, Ozawa D, Hara K, Honjo H, Altan B, Fukuchi M, Ishii H, Iwatsuki M, Sugimachi K, Sudo T, Iwaya T, Nishida N, Mimori K, Kuwano H, Mori M.
    • Journal Title

      Dis Esophagus.

      Volume: [Epub ahead of print] Issue: 7 Pages: 843-847

    • DOI

      10.1111/dote.12346

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Low PHLDA3 expression in oesophageal squamous cell carcinomas is associated with poor prognosis.2015

    • Author(s)
      Muroi H, Nakajima M, Satomura H, Takahashi M, Yamaguchi S, Sasaki K, Yokobori T, Miyazaki T, Kuwano H, Kato H.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 949-54

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGFBI Expression in Cancer Stromal Cells is Associated with Poor Prognosis and Hematogenous Recurrence in Esophageal Squamous Cell Carcinoma.2014

    • Author(s)
      Ozawa D, Yokobori T, Sohda M, Sakai M, Hara K, Honjo H, Kato H, Miyazaki T, Kuwano H.
    • Journal Title

      Ann Surg Oncol.

      Volume: Epub ahead of print

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] L-[3-18F]-α-methyltyrosine uptake by lymph node metastasis is a predictor of complete response to CRT in esophageal cancer.2014

    • Author(s)
      Sohda M, Miyazaki T, Honjyo H, Hara K, Ozawa D, Suzuki S, Tanaka N, Sano A, Sakai M, Yokobori T, Nakajima M, Fukuchi M, Kato H, Higuchi T, Tsushima Y, Kuwano H.
    • Journal Title

      Anticancer Res.

      Volume: 34 Pages: 7473-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salvage lymphadenectomy for recurrent esophageal cancer after chemoradiotherapy.2014

    • Author(s)
      Nakajima M, Domeki Y, Satomura H, Takahashi M, Sugawara A, Muroi H, Sasaki K, Yamaguchi S, Miyazaki T, Kuwano H, Kato H.
    • Journal Title

      Int Surg.

      Volume: 99 Issue: 4 Pages: 452-7

    • DOI

      10.9738/intsurg-d-13-00261.1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of pre-treatment 18F-FAMT PET to predict patient survival in squamous cell carcinoma of the esophagus treated by curative surgery.2014

    • Author(s)
      Sohda M, Sakai M, Honjyo H, Hara K, Ozawa D, Suzuki S, Tanaka N, Yokobori T, Miyazaki T, Fukuchi M, Higuchi T, Tsushima Y, Kuwano H.
    • Journal Title

      Anticancer Res.

      Volume: 34 Pages: 3623-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological significance of fluorine-18-α-methyltyrosine (FAMT) uptake on PET in patients with oesophageal cancer.2014

    • Author(s)
      Suzuki S, Kaira K, Ohshima Y, Ishioka NS, Sohda M, Yokobori T, Miyazaki T, Oriuchi N, Tominaga H, Kanai Y, Tsukamoto N, Asao T, Tsushima Y, Higuchi T, Oyama T, Kuwano H.
    • Journal Title

      Br J Cancer

      Volume: Epub ahead of print Issue: 8 Pages: 1985-1991

    • DOI

      10.1038/bjc.2014.142

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] L-[3-18F]-α-methyltyrosine accumulation as a definitive chemoradiotherapy response predictor in patients with esophageal cancer.2014

    • Author(s)
      Sohda M, Honjyo H, Hara K, Ozawa D, Suzuki S, Tanaka N, Sano A, Sakai M, Yokobori T, Inose T, Miyazaki T, Ojima H, Higuchi T, Tsushima Y, Kuwano H.
    • Journal Title

      Anticancer Res

      Volume: 34(2) Pages: 909-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of FDG-PET in screening of synchronous cancer of other organs in patients with esophageal cancer.2014

    • Author(s)
      Miyazaki T, Sohda M, Higuchi T, Tanaka N, Suzuki S, Sakai M, Yokobori T, Nakajima M, Fukuchi M, Tsushima Y, Kato H, Kuwano H.
    • Journal Title

      Anticancer Res

      Volume: 34(1) Pages: 283-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs.2014

    • Author(s)
      Yokobori T, Yokoyama Y, Mogi A, Endoh H, Altan B, Kosaka T, Yamaki E, Yajima T, Tomizawa K, Azuma Y, Onozato R, Miyazaki T, Tanaka S, Kuwano H.
    • Journal Title

      Mol Cancer Res.

      Volume: 12(1) Issue: 1 Pages: 32-7

    • DOI

      10.1158/1541-7786.mcr-13-0341

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical Resection of a Solitary Pulmonary Metastasis from Basaloid Squamous Cell Carcinoma of the Esophagus: A Case Report2014

    • Author(s)
      Kosaka T, Mogi A, Yamaki E, Miyazaki T, Kuwano H.
    • Journal Title

      Annals of Thoracic and Cardiovascular Surgery

      Volume: 20 Issue: Supplement Pages: 646-649

    • DOI

      10.5761/atcs.cr.13-00100

    • NAID

      130003387984

    • ISSN
      1341-1098, 2186-1005
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of total colonoscopy for screening of colon lesions in patients with esophageal cancer.2013

    • Author(s)
      Miyazaki T, Tanaka N, Sano A, Suzuki S, Sakai M, Yokobori T, Inose T, Sohda M, Nakajima M, Fukuchi M, Ojima H, Kato H, Kuwano H.
    • Journal Title

      Anticancer Res

      Volume: 33(11) Pages: 5113-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Re-thoracotomy for intrathoracic complications after esophagectomy for esophageal cancer2013

    • Author(s)
      Miyazaki T, Inose T, Tanaka N, Suzuki S, Hara K, Ozawa D, Yokobori T, Sakai M, Souda M, Fukuchi M, Kuwano H.
    • Journal Title

      Kyobu Geka

      Volume: 66(8 Suppl) Pages: 762-6

    • NAID

      40019746006

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Expression of receptor tyrosine kinases in esophageal carcinosarcoma.2013

    • Author(s)
      Sano A
    • Journal Title

      Oncol Rep.

      Volume: 29 Issue: 6 Pages: 2119-26

    • DOI

      10.3892/or.2013.2371

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I dose-escalation study of docetaxel, nedaplatin, and 5-fluorouracil combination chemotherapy in patients with advanced esophageal cancer.2013

    • Author(s)
      Miyazaki T
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 71 Issue: 4 Pages: 853-7

    • DOI

      10.1007/s00280-013-2076-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management of Barrett's esophageal carcinoma.2013

    • Author(s)
      Miyazaki T
    • Journal Title

      Surg Today

      Volume: 43 Issue: 4 Pages: 353-60

    • DOI

      10.1007/s00595-012-0468-2

    • NAID

      10031168019

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MiR-150 is associated with poor prognosis in esophageal squamous cell carcinoma via targeting the EMT inducer ZEB1.2013

    • Author(s)
      Yokobori T
    • Journal Title

      Cancer Sci.

      Volume: 104 Issue: 1 Pages: 48-54

    • DOI

      10.1111/cas.12030

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD47 expression regulated by the miR-133a tumor suppressor is a novel prognostic marker in esophageal squamous cell carcinoma.2012

    • Author(s)
      Suzuki S
    • Journal Title

      Oncol Rep.

      Volume: 28 Issue: 2 Pages: 465-72

    • DOI

      10.3892/or.2012.1831

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of lymph node capsular invasion in esophageal squamous cell carcinoma.2012

    • Author(s)
      Sakai M
    • Journal Title

      Ann Surg Oncol.

      Volume: 19 Issue: 6 Pages: 1911-7

    • DOI

      10.1245/s10434-012-2232-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin Level and Body Weight Loss After Esophagectomy for Esophageal Cancer2011

    • Author(s)
      Miyazaki T, Tanaka N, Hirai H, Yokobori T, Sano A, Sakai M, Inose T, Sohda M, Nakajima M, Fukuchi M, Kato H, Kuwano H
    • Journal Title

      J Surg Res.

      Volume: (Epub ahead of print) Issue: 1 Pages: 74-78

    • DOI

      10.1016/j.jss.2011.09.016

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNFAIP8 Overexpression : Clinical Relevance to Esophageal Squamous Cell Carcinoma2011

    • Author(s)
      Hadisaputri YE, Miyazaki T, Suzuki S, Yokobori T, Kobayashi T, Tanaka N, Inose T, Sohda M, Kuwano H
    • Journal Title

      Ann Surg Oncol

      Volume: (Epub ahead of print) Issue: S3 Pages: 589-596

    • DOI

      10.1245/s10434-011-2097-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of heat shock protein 110 expression and T lymphocyte infiltration in esophageal cancer2011

    • Author(s)
      Nakajima M, Kato H, Miyazaki T, Fukuchi M, Masuda N, Fukai Y, Sohda M, Inose T, Sakai M, Sano A, Tanaka N, Ahmad F, Kuwano H
    • Journal Title

      Hepatogastroenterology

      Volume: 58 Pages: 1555-1560

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ルシフェラーゼアッセイを利用した肉眼的に認識できない微小腹膜播種マウスモデルの確立2015

    • Author(s)
      横堀武彦、高橋遼、金泉、浅尾高行、桑野博行
    • Organizer
      第115回日本外科学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-16 – 2015-04-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] A new low-cost and high-quality device for in vivo luciferase assay in peritoneal dissemination mouse model2014

    • Author(s)
      Takehiko Yokobori, Ryo Takahashi, Yuji Kumakura, Hiroaki Honjo, Keigo Hara, Makoto Sakai, Makoto Sohda, Tatsuya Miyazaki, Takayuki Asao, Hiroyuki Kuwano
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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