| Project/Area Number |
22591452
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
MIZUKAMI Yoshiki 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (70530111)
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| Co-Investigator(Kenkyū-buntansha) |
KONO Koji 山梨大学, 大学院・医学工学総合研究部, 准教授 (40283204)
KAWAGUCHI Yoshihiko 山梨大学, 大学院・医学工学総合研究部, 助教 (80402048)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 胃十二指腸外科学 / 癌免疫療法 / 胃癌 / Th17 / Treg / Foxp3 / 癌ワクチン療法 / 癌微小環境 / IL-17 / 制御性T細胞 / アポトーシス / 酸化ストレス / ノックアウトマウス / Th17細胞 / Th1 / Th2 |
|---|
| Research Abstract |
In TILs(tumor-infiltrating lymphocytes) from patient with advanceddisease of gastric cancer, the frequency of Th17 cells was also significantly higher,but lower compared to early disease, than that in the normal gastric mucosa. In conclusion,the accumulation of Th17 cells as well as Treg in the tumor microenvironment of gastriccancer occurred in early disease and then the infiltration of Th17 cells graduallydecreased according to disease progression, in contrast to increased Treg.
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