The study of the mechanism of Wnt signal in the gastric cancer stem cell and the application to the cancer therapy.

Research Project

Project/Area Number	22591453
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Hiroshima University
Principal Investigator	TANABE Kazuaki 広島大学, 大学院・医歯薬保健学研究院, 講師 (40379847)
Co-Investigator(Kenkyū-buntansha)	SUZUKI Takahisa 広島大学, 病院, 病院助教 (80467779) TOKUMOTO Noriaki 広島大学, 病院, 病院助教 (90564980)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	胃十二指腸外科学 / 癌幹細胞 / 低酸素 / 癌 / Wntシグナル
Research Abstract	This study was originally planned to comfirm the specific marker for gastric cancer stem cell. In the study, we found that CD24 is one of factor of malignant potential in gastric cancer. Up-regulation of CD24 results the up-regulation of both adhesion and invasion. Furthermore, CD24 is more expressed under hypoxic condition compare to normoxia. We found that HIFs take apart in the induction of the CD24 expression. CD24 plays important rolls in gastric cancer invasion.

Report

(4 results)