| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The kinetics of γ-H2AX and Rad51 was found to correlate with sensitivity to chemotherapeutic agents in esophageal cancer cell lines when treated with cisplatin and 5-FU. Furthermore, it was found that 5-FU, which has been considered as an antimetabolite, also caused DNA double-strand breaks and homologous recombinational repair pathway was involved in the synergistic effect of cisplatin and 5-FU.
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