New chemoradiotherapy for esophageal cancer targeting DNA repair proteins
| Project/Area Number |
22591454
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
HIHARA Jun 広島大学, 原爆放射線医科学研究所, 講師 (10322744)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Morihito 広島大学, 原爆放射線医科学研究所, 教授 (70446045)
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| Co-Investigator(Renkei-kenkyūsha) |
TASHIRO Satoshi 広島大学, 原爆放射線医科学研究所, 教授 (20243610)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 食道外科学 / 食道癌 / 化学放射線療法 / DNA損傷 / Rad51 / γH2AX / 修復蛋白 |
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| Research Abstract |
The kinetics of γ-H2AX and Rad51 was found to correlate with sensitivity to chemotherapeutic agents in esophageal cancer cell lines when treated with cisplatin and 5-FU. Furthermore, it was found that 5-FU, which has been considered as an antimetabolite, also caused DNA double-strand breaks and homologous recombinational repair pathway was involved in the synergistic effect of cisplatin and 5-FU.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Involvement of ribonucleotide reductase-M1 in 5-fluorouracilinduced DNA damage in esophageal cancer cell lines2013
Author(s)
Aoki Y, Sakogawa K, Hihara J, Emi M, Hamai Y, Kono K, Shi L, Sun J, Kitao H, Ikura T, Niida H, Nakanishi M, Okada M, Tashiro S
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Journal Title
Int J Oncol
Volume: 42
Pages: 1951-1960
Related Report
Peer Reviewed
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