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The clinical significance of serum diamine oxidase(DAO) activity during chemotherapy in patients with carcinoma

Research Project

Project/Area Number 22591455
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionYamaguchi University

Principal Investigator

TAKEDA Shigeru  山口大学, 大学院・医学系研究科, 助教 (50403671)

Co-Investigator(Kenkyū-buntansha) YOSHINO Shigefumi  山口大学, 医学部附属病院, 准教授 (60294633)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords食道 / 化学療法 / 血中Diamine Oxidase(DAO)活性 / 食道癌 / 血中Diamine Oxidase(DAO)活性 / 血中Diamine Oxidase活性(DAO)
Research Abstract

DAO activities in the patients having GI toxicity significantly decreased on day 7 (p<0.01), and recovered to the level of pre-chemotherapy on day 28. In contrast, DAO activities in patients without GI toxicity did not change during chemotherapy. Serum DAO activity may be a sensitive biomarker of GI toxicity, and be useful to predict the risk of GI toxicity in esophageal cancer patients during chemotherapy.Enteral supplementation (GFO) is useful for preventing gastrointestinal toxicity during chemotherapy in patients with esophageal carcinoma.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2012 2010 Other

All Presentation (10 results)

  • [Presentation] 食道癌化学療法における血中Diamine Oxidase(DAO)活性と消化管毒性の関連についての検討2012

    • Author(s)
      武田 茂、吉野茂文、岡正朗
    • Organizer
      第20回日本消化器関連学会週間
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 化学療法時の消化管毒性と Diamine Oxidase(DAO)活性と推移の検討2012

    • Author(s)
      武田 茂、吉野茂文、岡正朗
    • Organizer
      第5回がん栄養療法研究会
    • Place of Presentation
      岡山プラザホテル(岡山市)
    • Year and Date
      2012-05-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 食道癌化学療法における血中Diamineoxidase(DAO)活性と消化管毒性の関連についての検討2012

    • Author(s)
      武田茂
    • Organizer
      第20回日本消化器関連学会週間
    • Place of Presentation
      神戸国際展示場(兵庫)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 食道癌化学療患者における血中 DAO 活性の測定2010

    • Author(s)
      武田 茂、吉野茂文、岡正朗
    • Organizer
      第8回日本消化器外科大会(JDDW2010)
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 食道癌化学療患者における血中DAO活性の測定2010

    • Author(s)
      武田茂
    • Organizer
      第8回日本消化器外科大会(JDDW2010)
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] The clinical significance of serum diamine oxidase activity during chemotherapy in patients with esophageal carcinoma2010

    • Author(s)
      武田 茂、吉野茂文、岡正朗
    • Organizer
      12th World Congress of the International Society for Disease of Esophagus
    • Place of Presentation
      城山観光ホテル(鹿児島市)
    • Year and Date
      2010-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] The clinical significance of serum diamine oxidase activity during chemotherapy in patients with esophageal carcinoma2010

    • Author(s)
      武田茂
    • Organizer
      12th World Congress of the International Sociaty for Disease of Esophagus
    • Place of Presentation
      鹿児島市 城山観光ホテル
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道癌 FP療法における血中 Diamine Oxidase 活性2010

    • Author(s)
      武田 茂、吉野茂文、岡正朗
    • Organizer
      第64回日本食道学会学術集会
    • Place of Presentation
      石橋文化ホール(久留米市)
    • Year and Date
      2010-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 食道癌FP療法における血中Diamine Oxidase活性2010

    • Author(s)
      武田茂
    • Organizer
      第64回日本食道学会学術集会
    • Place of Presentation
      久留米市石橋文化ホール
    • Year and Date
      2010-09-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 化学療法時の消化管毒性とDiamineoxidase(DAO)活性と推移の検討

    • Author(s)
      武田茂
    • Organizer
      第5回がん栄養療法研究会
    • Place of Presentation
      岡山プラザホテル(岡山)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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