The mobilization and recruitment of endothelial progenitor cells contribute to acceleration of tumor growth after surgery

• Project/Area Number: 22591456
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Yamaguchi University
• Principal Investigator: ENOKI Tadahiko 山口大学, 大学院・医学系研究科, 大学院医学系研究科 (80311819)
• Co-Investigator(Kenkyū-buntansha): UEDA Kazuhiro 山口大学, 医学部附属病院, 講師 (90420520)
• Research Collaborator: TAKEMOTO Yoshihiro 山口大学, 医学部附属病院, 助教 (50622213)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 手術侵襲 / 血管内皮前駆細胞

Research Abstract

Using an established tumor model in mice, we performed open gastrotomy. After gastrotomy, the tumor volume was almost double in mice, and then the number of bone marrow-derived stem cells (BMSCs) found in tumor tissue significantly increased in mice. Furthermore, administration of AMD3100, a known as CXCR4 antagonist significantly inhibited the recruitment of BMSCs and negated the acceleration in tumor growth after surgery. In clinical practice, we examined the recruitment of BMSCs and the concentration of VEGF in the peripheral blood after surgery in gastric cancer patients. The concentration of VEGF in the peripheral blood was higher than that before surgery, whereas the recruitment of BMSCs to the peripheral blood after surgery didn’t increase.

Research Products

• [Journal Article] Operative injury accelerates tumor growth by inducing mobilization and recruitment of bone marrow-derived stem cells (2011)
  • Author(s): Yoshihiro Takemoto, Tao-Sheng Li, Masayuki Kubo, Mako Ohshima, Kazuhiro Ueda, Eijirou Harada, Tadahiko Enoki, Mariko Okamoto, Yoichi Mizukami, Tomoaki Murata, Kimikazu Hamano
  • Journal Title: SURGERY Volume: 149巻 Pages: 792-800
  • Peer Reviewed
• [Presentation] Surgical injury accelerates tumor growth by inducing the mobilization and recruitment of bone marrow-derived stem cells (2011)
  • Author(s): Yoshihiro Takemoto
  • Organizer: INTERNATIONAL SURGICAL WEEK ISW 2011
  • Place of Presentation: PacificoYokohama, Yokohama
  • Year and Date: 2011-08-30
• [Presentation] 手術侵襲による骨髄由来幹細胞の動員・集積が癌増大を促進させる (2011)
  • Author(s): 竹本圭宏
  • Organizer: 日本外科学会
  • Place of Presentation: (震災のにめWeb上で開催)
  • Year and Date: 2011-04-07
• [Presentation] The mobilization and recruitment of bone marrow-derived stem cells contributes to acceleration of tumor growth after surgery (2011)
  • Author(s): Yoshihiro Takemoto
  • Organizer: American Association for Cancer Research 102nd ANNUAL MEETING
  • Place of Presentation: Florida USA
  • Year and Date: 2011-04-06
• [Remarks] 山口大学大学院器官病態外科
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~surg-1/