| Project/Area Number |
22591456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
ENOKI Tadahiko 山口大学, 大学院・医学系研究科, 大学院医学系研究科 (80311819)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Kazuhiro 山口大学, 医学部附属病院, 講師 (90420520)
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| Research Collaborator |
TAKEMOTO Yoshihiro 山口大学, 医学部附属病院, 助教 (50622213)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 手術侵襲 / 血管内皮前駆細胞 |
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| Research Abstract |
Using an established tumor model in mice, we performed open gastrotomy. After gastrotomy, the tumor volume was almost double in mice, and then the number of bone marrow-derived stem cells (BMSCs) found in tumor tissue significantly increased in mice. Furthermore, administration of AMD3100, a known as CXCR4 antagonist significantly inhibited the recruitment of BMSCs and negated the acceleration in tumor growth after surgery. In clinical practice, we examined the recruitment of BMSCs and the concentration of VEGF in the peripheral blood after surgery in gastric cancer patients. The concentration of VEGF in the peripheral blood was higher than that before surgery, whereas the recruitment of BMSCs to the peripheral blood after surgery didn’t increase.
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