| Project/Area Number |
22591460
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
MATSUMOTO Masataka 鹿児島大学, 大学院・医歯学総合研究科, 客員研究員 (40398293)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIKADO Yasuto 鹿児島大学, 医学部・歯学部付属病院, 助教 (30464465)
KITA Yoshiaki 鹿児島大学, 医学部・歯学部付属病院, 特任助教 (30570692)
NATSUGOE Shoji 鹿児島大学, 医歯学総合研究科, 教授 (70237577)
ISHIGAMI Sumiya 鹿児島大学, 医学部・歯学部付属病院, 講師 (90325803)
北薗 正樹 鹿児島大学, 医学部・歯学部附属病院, 助教 (30398276)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | リンパ管新生 / 血管新生 / 微小環境 / 消化器癌 |
|---|
| Research Abstract |
VEGF-C and VEGF-D induced lymphangiogenesis followed by the lymph node metastasis. And the lymphangiogenesis occurred also in the lymph nodes as well as primary tumor. In the cancer microenvironment, CD133, CD166, E-cadherin, Slug, BMP-7,and regulatory T cell were closely related to lymphatic invasion and lymph node metastasis.
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