Analysis of Wnt signaling pathway in esophageal cancer
| Project/Area Number |
22591462
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIOZAKI Midori 名古屋市立大学, 大学院・医学研究科, 助教 (90531004)
KATADA Takeyasu 名古屋市立大学, 大学院・医学研究科, 臨床研究医 (70529164)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | WNT シグナル / 食道癌 / WNTシグナル / マイクロRNA / Wntシグナル / TCF4 / ベータカテニン / TCF / microRNA |
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| Research Abstract |
1．We found TCF7L2 binding site in the promoter domain of microRNA. Especially, we found the TCF7L2 binding site in the promotor region of mir-129 which is involved in the poor progonosis of the patients with esophageal cancer.
2．We performed siRNA of beta catenin using esophageal cancer cell line TE11. And si- beta catenin induced the cell death of esophageal cancer cell.
3．We analyzed the comparison between the clinico-pathological factor and the data of immunohistochemistry of beta catenin, E cadherin and TCF4.
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Report
(4 results)
Research Products
(29 results)
