Impact of PSK and DT on peptide vaccine against gastrointestinal cance

• Project/Area Number: 22591466
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka City University
• Principal Investigator: TANAKA Hiroaki 大阪市立大学, 大学院・医学研究科, 講師 (90382168)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 食道外科学 / 胃癌 / 樹状細胞 / 抗腫瘍免疫 / 免疫学 / 臨床

Research Abstract

We investigated production of cytokines by gastric cancer cell lines and examined the effect of supernatant of cancer cell lines on phenotypes of monocyte-derived DCs. Also we examined infiltration of CD11c and CD11b positive cells in clinical

Research Products

• [Journal Article] Association of MHC Class I Expression and Lymph Node Metastasis of Gastric Carcinoma (2013)
  • Author(s): Mami Yoshii
  • Journal Title: Hepato-gastroenterology Volume: 60
  • Peer Reviewed
• [Journal Article] Association of location of lymph node metastases with postoperative recurrence of esophageal squamous cell carcinoma (2012)
  • Author(s): Tanaka H, Ohira M, Kubo N, Muguruma K, Yamashita Y, Sawada T, Hirakawa K
  • Journal Title: Anticancer Research Volume: 32 Pages: 3421-3426
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22843925
  • Peer Reviewed
• [Journal Article] Impact of adjuvant immunochemotherapy using protein-bound polysaccharide-K on overall survival of patients with gastric cancer (2012)
  • Author(s): Tanaka H, Muguruma K, Ohira M, Kubo N, Yamashita Y, Maeda K, Sawada T, Hirakawa K
  • Journal Title: Anticancer Research Volume: 32 Pages: 3427-3433
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22843926
  • Peer Reviewed
• [Journal Article] Expression of forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach (2012)
  • Author(s): Yoshii M, Tanaka H, Ohira M, Muguruma K, Iwauchi T, Lee T, Sakurai K, Kubo N, Yashiro M, Sawada T, Hirakawa K
  • Journal Title: British Journal of Cancer Volume: 106 Issue: 10 Pages: 1668-1674
  • DOI: 10.1038/bjc.2012.141
  • Peer Reviewed
• [Journal Article] Correlation between efficacy of PSK postoperative adjuvant immunochemotherapy for gastric cancer and expression (2012)
  • Author(s): Ito G, Tanaka H, Ohira M, Yoshii M, Muguruma K, Kubo N, Yashiro M, Yamada N, Maeda K, Sawada T, Hirakawa K
  • Journal Title: Experimental and Therapeutic Medicine Volume: 3 Pages: 925-930
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22969994
  • Peer Reviewed
• [Journal Article] Correlation between efficacy of PSK postoperative adjuvant immunochemotherapy for gastric cancer and expression of MHC class I (2012)
  • Author(s): Gentaro Ito
  • Journal Title: Experimental and Therapeutic Medicine Volume: 3 Pages: 925-930
  • Peer Reviewed
• [Journal Article] Impact of adjuvant immunochemotherapy using protein-bound polysaccharide-K on overall survival of patients with gastric cancer (2012)
  • Author(s): Hiroaki Tanaka
  • Journal Title: Anticancer Research Volume: 32 Pages: 3427-33
  • Peer Reviewed
• [Journal Article] Association of location of lymph node metastases with postoperative recurrence of esophageal squamous cell carcinoma (2012)
  • Author(s): Hiroaki Tanaka
  • Journal Title: Anticancer Research Volume: 32 Pages: 3421-6
  • Peer Reviewed
• [Journal Article] Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer (2011)
  • Author(s): Hoshi H, Sawada T, Uchida M, Saito H, Iijima H, Toda-Agetsuma M, Wada T, Yamazoe S, Tanaka H, Kimura K, Kakehashi A, Wei M, Hirakawa K, Wanibuchi H
  • Journal Title: International Journal of Oncology Volume: 38 Issue: 3 Pages: 619-627
  • DOI: 10.3892/ijo.2011.911
  • Peer Reviewed
• [Journal Article] Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct (2011)
  • Author(s): Hoshi H, Saito H, Iijima H, Uchida M, Wada T, Ito G, Tanaka H, Sawada T, Hirakawa K
  • Journal Title: Oncology Reports Volume: 25 Issue: 4 Pages: 905-913
  • DOI: 10.3892/or.2011.1155
  • Peer Reviewed
• [Journal Article] Identification of HLA-A*0201- and A*2402-restricted epitopes of mucin 5AC expressed in advanced pancreatic cancer. (2011)
  • Author(s): Yamazoe S, Tanaka H, Iwauchi T, Yoshii M, Ito G, Amano R, Yamada N, Sawada T, Ohira M, Hirakawa K
  • Journal Title: Pancreas Volume: 40 Issue: 6 Pages: 896-904
  • DOI: 10.1097/mpa.0b013e31821ad8d1
  • Peer Reviewed
• [Journal Article] Identification of HLA-A*2402-restricted epitope peptide derived from ERas oncogene expressed in human scirrhous gastric cancer (2011)
  • Author(s): Iwauchi T, Tanaka H, Yamazoe S, Yashiro M, Yoshii M, Kubo N, Muguruma K, Sawada T, Ohira M, Hirakawa K
  • Journal Title: Cancer Science Volume: 102 Pages: 683-689
  • NAID: 10029291798
  • Peer Reviewed
• [Journal Article] Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer (2011)
  • Author(s): Tanaka H, Hirakawa K., et al
  • Journal Title: Oncology Reports Volume: 25 Pages: 905-913
  • Peer Reviewed
• [Journal Article] Identification of HLA-A^*0201- and A^*2402-restricted epitopes of mucin 5AC expressed in advanced pancreatic cancer (2011)
  • Author(s): Tanaka H, Hirakawa K., et al
  • Journal Title: Pancreas Volume: 40 Pages: 896-904
  • Peer Reviewed
• [Journal Article] Identification of HLA-A*2402-restricted epitope peptide derived from Eras oncogene expressed in human scirrhous gastric cancer (2011)
  • Author(s): Tanaka H, Hirakawa K., et al
  • Journal Title: Cancer Science Volume: 102 Pages: 683-689
  • NAID: 10029291798
  • Peer Reviewed
• [Journal Article] Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound (2011)
  • Author(s): Tanaka H, Hirakawa K., et al
  • Journal Title: Oncology Reports Volume: 25 Pages: 905-913
  • Peer Reviewed
• [Journal Article] Transforming growth factor b signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity (2010)
  • Author(s): Tanaka H, Hirakawa K., et al
  • Journal Title: Oncology Reports Volume: 24 Pages: 1637-1643
  • Peer Reviewed
• [Presentation] 胃癌転移リンパ節における免疫細胞プロファイルの検討 (2012)
  • Author(s): 田中浩明
  • Organizer: 第67回日本消化器外科学会総会
  • Place of Presentation: 富山市
  • Year and Date: 2012-07-19
• [Presentation] 胃癌による CD11b 陽性樹状細胞誘導の意義 (2012)
  • Author(s): 田中浩明
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2012-04-12
• [Presentation] Relationship between loss of heterozygosity of HLA-A gene and HLA class I expression in gastric cancer (2012)
  • Author(s): Tanaka H
  • Organizer: American Association for Cancer Research 103rd Annual Meeting
  • Place of Presentation: Chicago USA
  • Year and Date: 2012-04-01
• [Presentation] 胃癌細胞による樹状細胞phenotype の変化 (2012)
  • Author(s): 田中浩明
  • Organizer: 第84回日本胃癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-02-09
• [Presentation] Predictive value of metastatic lymph node ratio in diagnosis of recurrence after surgical resection of gastric cancer (2012)
  • Author(s): Hiroaki Tanaka
  • Organizer: 103rd Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Chicago, USA
• [Presentation] 胃癌によるCD11b 陽性樹状細胞誘導の意義 (2012)
  • Author(s): 田中浩明
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉市、幕張メッセ
• [Presentation] 胃癌転移リンパ節における免疫細胞プロファイルの検討 (2012)
  • Author(s): 田中浩明
  • Organizer: 第67回日本消化器外科学会総会
  • Place of Presentation: 富山市、富山国際会議場
• [Presentation] Association of metastatic lymph noderatio with peritoneal metastasis of gastric cancer (2012)
  • Author(s): Hiroaki Tanaka
  • Organizer: 10th International Conference of the Asian Clinical Oncology Society
  • Place of Presentation: Seoul, Korea
• [Presentation] 胃癌に発現する ERas をターゲットとした HLA-A*2402 拘束性エピトープペプチドの同定 (2011)
  • Author(s): 田中浩明
  • Organizer: 第36回日本外科系連合学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-16
• [Presentation] スキルス胃癌細胞による樹状細胞の直接的機能抑制 (2011)
  • Author(s): 田中浩明
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-26
• [Presentation] 制御性 T 細胞浸潤と胃癌組織型との関係 (2011)
  • Author(s): 田中浩明
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-26
• [Presentation] The impact of adjuvant immunochemotherapy using protein-bound polys accharide-K on overall survivall of gastric cancer (2011)
  • Author(s): Tanaka H, Hirakawa K., et al
  • Organizer: AACR 2011
  • Place of Presentation: Florida
  • Year and Date: 2011-04-02
• [Presentation] Impact of combination of PSK with TGF-beta inhibitor on anti-tumor immunity (2010)
  • Author(s): Tanaka H, Hirakawa K., et al
  • Organizer: AACR 101^<st> annual meeting
  • Place of Presentation: Washington, D.C.
  • Year and Date: 2010-04-17