Therapeutic aspects from theanalysis of epithelial-mesenchymal transition (EMT) in gastric cancer.

• Project/Area Number: 22591469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Keio University
• Principal Investigator: WADA Norihito 慶應義塾大学, 医学部, 講師 (40256087)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Hiroya 慶應義塾大学, 医学部, 講師 (20265838) ; HAYASHIDA Tetsu 慶應義塾大学, 医学部, 助教 (80327543)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 胃十二指腸外科学 / 胃癌 / 上皮間葉移行 / リンパ節転移 / HOXB9 / EMT / 浸潤転移 / リンパ管新生 / スキルス胃癌 / ＥＭＴ / MMP / TMK-1 / MKN74 / 転移浸潤 / 臨床病理

Research Abstract

We have conducted our research in order to investigate the possibility of therapeutic application of the concept of epithelial-mesenchymal transition (EMT) for the treatment of advanced gastric cancer. Gastric cancer tissue from the patient treated in our

Research Products

• [Journal Article] Clinical utility of the Revised Cardiac Risk Index in non-cardiac surgery for elderly patients: a prospective cohort study. (2013)
  • Author(s): Hirano Y, Takeuchi H, Suda K, Oyama T, Nakamura R, Takahashi T, Kawakubo H, Wada N, Saikawa Y, Obara H, Jinno H, Hasegawa H, Tanabe M, Kitagawa Y
  • Journal Title: Surg Today
  • Peer Reviewed
• [Journal Article] Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients. (2013)
  • Author(s): Kanda T, Nishida T, Wada N, Kobayashi O,Yamamoto M, Sawaki A, Boku N, Koseki M, Doi T, Toh Y, Kakeji Y, Sugiyama T, Komatsu Y, Kikuchi S, Ogoshi K, Katai H, Miyachi K, Hirota S, Ohtsu A
  • Journal Title: Int J Clin Oncol Volume: 18 Pages: 38-45
  • NAID: 10031176233
  • Peer Reviewed
• [Journal Article] Intraoperative fluorescence lymphography using indocyanine green in a patient with chylothorax after esophagectomy: report of a case. (2013)
  • Author(s): Kaburagi T, Takeuchi H, Oyama T, Nakamura R, Takahashi T, Wada N, Saikawa Y, Kamiya S, Tanaka M, Wada T, Kitagawa Y.
  • Journal Title: Surg Today Volume: 43 Issue: 2 Pages: 206-210
  • DOI: 10.1007/s00595-012-0391-6
  • NAID: 10031167990
  • Peer Reviewed
• [Journal Article] Antitumor effect of cetuximab in combination with S-1 in EGFR-amplified gastric cancer cells (2012)
  • Author(s): Fukuda K, Saikawa Y, Takahashi M, Takahashi T, Wada N, Kawakubo H, Takeuchi H, Kitagawa Y
  • Journal Title: Int J Oncol Volume: 40 Pages: 975-982
  • Peer Reviewed
• [Journal Article] Role of integrin α1 subunits in gastric cancer patients with peritoneal dissemination. (2012)
  • Author(s): Fukuda K, Saikawa Y, Yagi H, Wada N, Takahashi T, Kitagawa Y
  • Journal Title: Mol Med Repor Volume: 5 Pages: 336-40
  • Peer Reviewed
• [Journal Article] Single-incision laparoscopic surgery for partial gastrectomy in patients with a gastric submucosal tumor. (2012)
  • Author(s): Takahashi T, Takeuchi H, Kawakubo H, Saikawa Y, Wada N, Kitagawa Y.
  • Journal Title: Am Surg Volume: 78 Pages: 447-450
  • Peer Reviewed
• [Journal Article] Antitumor effect of cetuximab in combination with S-1 in EGFR-amplified gastric cancer cells. (2012)
  • Author(s): Fukuda K, Saikawa Y, Takahashi M, Takahashi T, Wada N, Kawakubo H, Takeuchi H, Kitagawa Y.
  • Journal Title: Int J Oncol Volume: 40(4) Issue: 4 Pages: 975-82
  • DOI: 10.3892/ijo.2011.1279
  • Peer Reviewed
• [Journal Article] Role of integrin α1 subunits in gastric cancer patients with peritoneal dissemination. (2012)
  • Author(s): Fukuda K, Saikawa Y, Yagi H, Wada N, Takahashi T, Kitagawa Y.
  • Journal Title: Mol Med Repor Volume: 5 Pages: 336-340
  • DOI: 10.3892/mmr.2011.642
  • Peer Reviewed
• [Journal Article] Laparoscopy-assisted proximal gastrectomy with sentinel node mapping for early gastric cancer. (2011)
  • Author(s): Takeuchi H, Oyama T, Kamiya S, Nakamura R, Takahashi T, Wada N, Saikawa Y, Kitagawa Y
  • Journal Title: World J Surg Volume: 35 Pages: 2463-2471
  • Peer Reviewed
• [Journal Article] Phase I study of neoadjuvant chemoradiotherapy consisting of S-1 and cisplatin for patients with resectable advanced gastric cancer (KOGC-01) (2011)
  • Author(s): Takahashi T, Saikawa Y, Takaishi H, Takeuchi H, Wada N, Oyama T, Fukuda K, Fukada J, Kawaguchi O, Shigematsu N, Kitagawa Y.
  • Journal Title: Anticancer Res Volume: 31 Pages: 3079-3083
  • Peer Reviewed
• [Journal Article] 胃癌肝転移の治療 (2011)
  • Author(s): 和田則仁, 他
  • Journal Title: 臨牀消化器内科 Volume: 26 Pages: 435-441
• [Journal Article] 自動縫合器・吻合器 (2011)
  • Author(s): 和田則仁, 他
  • Journal Title: 消化器外科 Volume: 34 Pages: 39-45
• [Journal Article] わが国のGIST診療ガイドラインの現状、問題点と改訂点 (2011)
  • Author(s): 和田則仁, 他
  • Journal Title: 消化器外科 Volume: 34 Pages: 143-150
• [Journal Article] Feasibility and efficacy of combination chemotherapy with S-1 and fractional Cisplatin for advanced gastric cancer (2010)
  • Author(s): Takahashi T, Saikawa Y, Takaishi H, Takeuchi H, Wada N, Oyama T, Nakamura R, Kitagawa Y
  • Journal Title: Anticancer Res Volume: 30 Pages: 3759-3762
  • Peer Reviewed
• [Journal Article] Octreotide acetate enables the administration of chemoradiotherapy, including the oral anticancer drug S-1, in gastric cancer patients with malignant gastrointestinal obstruction (2010)
  • Author(s): Takahashi T, Saikawa Y, Igarashi T, Tsuwano S, Kumagai K, Nakamura R, Ooyama T, Wada N, Takeuchi H, Takaishi H, Kitagawa Y.
  • Journal Title: Oncology Letters Volume: 1 Pages: 673-677
  • Peer Reviewed
• [Presentation] Surgery Clinical significance of cancer cells in lymphatic vessels between primary tumor and sentinel nodes gastric cancer (2012)
  • Author(s): Takeuchi H. Gastric Cancer
  • Organizer: 10th International Conference of the Asian Clinical Oncology Society
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-06-14
• [Presentation] HOXB9 expression and gastric cancer progression (2012)
  • Author(s): Fumihiko Kato, Norihito Wada, Tetsu Hayashida, Kazumasa Fukuda, Rieko Nakamura, Tsunehiro Takahashi, Hirofumi Kawakubo, Hiroya Takeuchi, Yoshiro Saikawa, Yuko Kitagawa
  • Organizer: 9th International Symposium on Cancer Research and Therapy
  • Place of Presentation: Tokyo
• [Presentation] Strategies for the treatment of inguinal hernia (2012)
  • Author(s): Norihito Wada, Toshiharu Furukawa, Yuko Kitagawa
  • Organizer: 5th Scientific Meeting of the Japan-Hungarian Surgical Society
  • Place of Presentation: Budapest, Hungary
• [Presentation] Single incision totally extraperitoneal inguinal hernia repair with self-fixating mesh (2012)
  • Author(s): Norihito Wada, Toshiharu Furukawa, Yuko Kitagawa
  • Organizer: 20th International Congress of the European Association for Endoscopic Surgery
  • Place of Presentation: Brussels, Belgium
• [Presentation] TANKO laparoscopic totally extraperitoneal (TEP) inguinal hernioplasty under conscious sedation (2012)
  • Author(s): Norihito Wada
  • Organizer: Postgraduate Course, 20th International Congress of the European Association for Endoscopic Surgery
  • Place of Presentation: Brussels, Belgium
  • Invited
• [Presentation] Inguinal hernia repair with Lichtenstein technique (2012)
  • Author(s): Norihito Wada, Yuko Kitagawa
  • Organizer: 5th International Hernia Congress
  • Place of Presentation: New York, USA
  • Invited
• [Presentation] Single incision totally extraperitoneal inguinal hernia repair with self-fixating mesh (2012)
  • Author(s): Norihito Wada, Toshiharu Furukawa, Yuko Kitagawa
  • Organizer: 20th International Congress of the European Association for
  • Place of Presentation: Brussels, Belgium
• [Presentation] Phase I study of preoperative chemoradiotherapy consisted of S-1 and cisplatin for patients with curable advanced gastric cancer (KOGC-01) (2011)
  • Author(s): Takahashi T
  • Organizer: International Surgical Week
  • Place of Presentation: Yokohama
  • Year and Date: 2011-08-29
• [Presentation] Retrospective analysis for prognostic outcome of gastric cancer in young patients (2011)
  • Author(s): Nakamura R.
  • Organizer: International Surgical Week
  • Place of Presentation: Yokohama
  • Year and Date: 2011-08-29
• [Presentation] The assessment of the procedure of the additional gastrectomy with sentinel node (SN) mapping after endoscopic submucosal dissection (ESD) (2011)
  • Author(s): Kamiya S
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-22
• [Presentation] Feasibility and efficacy of combination chemotherapy with S-1 and fractional cisplatin for advanced gastric cancer (2011)
  • Author(s): Wada T
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-22
• [Presentation] Long-term outcomes of laparoscopic wedge resection for gastrointestinal stromal tumor (GIST) of the stomach (2011)
  • Author(s): Wada N
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-22
• [Presentation] Histological complete response for patients with advanced gastric cancer after preoperative chemoradiation therapy with S-1 and low-dose cisplatin. (2011)
  • Author(s): Mayanagi S
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-21
• [Presentation] Laparoscopy-assisted proximal gastrectomy based on the SN concept and esophagogastric anastomosis using the orvil. (2011)
  • Author(s): Takeuchi H.
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-21
• [Presentation] The role of CD44 variant in the development of spasmolytic polypeptiede expressing metaplasia (SPEM) and gastric cancer. (2011)
  • Author(s): Wada T.
  • Organizer: AACR 102nd Annual Meeting
  • Place of Presentation: Florida, USA
  • Year and Date: 2011-04-03
• [Presentation] Oncologic Outcomes of Laparoscopic Surgery for Gastrointestinal Stromal Tumor (GIST) of the Stomach (2011)
  • Author(s): Wada N
  • Organizer: SAGES
  • Place of Presentation: San Antonio, USA
  • Year and Date: 2011-03-31
• [Presentation] Validation study of sentinel lymph node mapping using radio- and dye-guided methods in gastric cancer: 431 cases at a single institution (2011)
  • Author(s): Niihara M
  • Organizer: 8th Gastrointestinal Cancers Symposium
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2011-01-20
• [Presentation] Availability of sentinel node as predictive index of lymph node metastases to early-stage gastric cancer surgery. (2011)
  • Author(s): Kamiya S
  • Organizer: 8th Gastrointestinal Cancers Symposium
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2011-01-20
• [Presentation] The Microanatomic Location of Metastatic Gastric Cancer in Sentinel Lymph Nodes (2010)
  • Author(s): Niihara M
  • Organizer: The 7th International Sentinel Node Society Meeting
  • Place of Presentation: Yokohama
  • Year and Date: 2010-11-18
• [Presentation] Validation Study of Sentinel Lymph Node Mapping Using Radio-and Dye-guided Method in Gastric Cancer (2010)
  • Author(s): Niihara M.
  • Organizer: The 7th International Sentinel Node Society Meeting
  • Place of Presentation: Yokohama
  • Year and Date: 2010-11-18
• [Presentation] Evaluation of the Proximal Gastrectomy with Sentinel Node Biopsy in Gastric Cancer. (2010)
  • Author(s): Kamiya S
  • Organizer: The 7th International Sentinel Node Society Meeting
  • Place of Presentation: Yokohama
  • Year and Date: 2010-11-18
• [Presentation] Evaluation of the Pylorus-preserving Gastrectomy with Sentinel Node Biopsy during an Operation for Less Invasive Surgery (2010)
  • Author(s): Kamiya S.
  • Organizer: The 7th International Sentinel Node Society Meeting
  • Place of Presentation: Yokohama
  • Year and Date: 2010-11-18
• [Presentation] 癌性幽門狭窄症に対する内視鏡的ステント挿入術の意義 (2010)
  • Author(s): 和田則仁, 他
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-10-29
• [Presentation] Laparoscopic gastrojejunostomy for malignant gastric outlet obstruction (2010)
  • Author(s): Wada N
  • Organizer: 12th World Congress of Endoscopic Surgery
  • Place of Presentation: National Harbor, USA
  • Year and Date: 2010-04-16
• [Book] 今日の治療指針2012年版 (2013)
  • Author(s): 和田則仁、古川俊治
  • Publisher: 医学書院
• [Book] 今日の治療指針 2012 年版 (2012)
  • Author(s): 和田則仁、古川俊治
  • Publisher: 医学書院
• [Book] センチネルリンパ節生検 手技・エビデンス・ピットフォール (2012)
  • Author(s): 竹内裕也，中村理恵子，高橋常浩，和田則仁，川久保博文，才川義朗，大森泰，北川雄光
  • Publisher: 日本医事新報社
• [Book] 症候群ハンドブック (2011)
  • Author(s): 和田則仁
  • Total Pages: 255
  • Publisher: 中山書店
• [Book] 今日の治療指針(胃癌治療ガイドライン医師用) (2011)
  • Author(s): 和田則仁、古川俊治
  • Publisher: 医学書院(東京)
• [Book] 消化器単孔式腹腔鏡下手術 (2010)
  • Author(s): 田邉稔, 河地茂行, 板野理, 篠田昌宏, 和田則仁, 大島剛, 小野嘉大, 谷紀幸, 上田政和, 北川雄光
  • Publisher: 南山堂
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~nori/hp/research.htm
• [Remarks] 研究について
  • URL: http://plaza.umin.ac.jp/~nori/hp/research.htm
• [Remarks] 研究について
  • URL: http://plaza.umin.ac.jp/̃nori/hp/research.htm
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~nori/hp/research.htm