| Project/Area Number |
22591470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIDA Atsuo 東京慈恵会医科大学, 医学部, 助教 (00338906)
OMURA Nobuo 東京慈恵会医科大学, 医学部, 准教授 (70271301)
|
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| Co-Investigator(Renkei-kenkyūsha) |
TAKADA Koji 東京慈恵会医科大学, 医学部, 准教授 (30179452)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
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| Keywords | ユビキチン / SUMO-1 / 食道癌 |
|---|
| Research Abstract |
SUMO-1(small ubiquitin-related modifier-1) is a novel ubiquitin -like protein that is conjugated like ubiquitin by a set of enzymes to cellular regulatory proteins including oncogenes and tumor suppressor genes. In this study, we aimed to investigate the significance of SUMO-1 expressions in esophageal cancer as a prognostic factor. In an esophagus cancer, revelation of SUMO-1 was accepted with a core or cytoplasm and SUMO-1 binding protein of varieties was accepted. The high revelation group had intentionally much lymph node metastasis and vessel invasion. Moreover, the life prognosis also accepted the tendency for a high revelation group to be bad.
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