| Project/Area Number |
22591472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Shizuoka Cancer Center Research Institute |
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Principal Investigator |
TERASHIMA Masanori 静岡県立静岡がんセンター(研究所), 胃外科, 部長 (40197794)
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIZUKI Tohru 静岡県立静岡がんセンター, 研究所, 研究員 (00117780)
OSHIMA Keiichi 静岡県立静岡がんセンター, 研究所, 研究員 (10399587)
HATAKEYAMA Keiichi 静岡県立静岡がんセンター, 研究所, 研究員 (20564157)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌 / 遺伝子 / 腫瘍マーカー / 微小転移 / 外科 / 転移 / 種瘍マーカー |
|---|
| Research Abstract |
We evaluated the possibility to establish predictive markers for gastric cancer metastasis using splicing variant developed from highly metastatic gastric cancer cell lines. Peripheral blood was corrected from 94 patient with gastric cancer and expression of ARHGDIBsv1, ALD0G4b, XAF1sv3 were measured. Expression level of each variant was compared with clinicopathologic factors. ARHGDIBsv1 expression was up regulated in advanced cancer, and XAF1sv3 expression was up regulated in patients with undifferentiated type of cancer. However, there was no significant correlation between gene expression and tumor metastasis. With respect to newly marker development, we found the up regulation of secretary protein isoform Quiescin Q6 sulfhydryl oxidase 1 in highly metastatic gastric cancer cell lines.
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