Detection of free intraperitoneal cancer cells and chemosensitivity testing using gene expression analysis for gastric cancer patients
| Project/Area Number |
22591473
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
ITO Seiji 愛知県がんセンター(研究所), 腫瘍病理学部, 研究員 (50393129)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 癌 / 微小転移 / 抗癌剤受性 / 抗癌剤感受性 / 胃がん |
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| Research Abstract |
This study aimed at integrated development of the genetic detection of peritoneal micrometastases and effective therapy based on biological characteristics of peritoneal micrometastases. Microarray analysis was performed for the cell lines with low CEA expression and new marker genes were identified. The predicting model for peritoneal metastasis was constructed. Both sensitive and resistant cell lines for paclitaxel were establishedandgene expression profiling was compared with parent cell line. The selected genes were validated by clinical samples andidentified as paclitaxel-resistance related genes.
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Report
(4 results)
Research Products
(30 results)
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[Presentation] Development of rapid isolation device for circulating tumor cells (CTCs) using size-based filtrationmethod and its application for single cell gene expression analysis2012
Author(s)
YusaA,MasudaT, Yamamoto S, Niimi M, Douke H, Okochi M, Toneri M, Ito S, Honda H, Arai F, Nakanishi H.
Organizer
3rd Annual Meeting World CTC
Place of Presentation
Hyatt Regency(Boston,USA)
Year and Date
2012-11-13
Related Report
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