Investigation of the mechanisms of pouchitis after IPAA for patients with ulcerative colitis.

• Project/Area Number: 22591476
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: OGAWA Hitoshi 東北大学, 病院, 講師 (00312570)
• Co-Investigator(Kenkyū-buntansha): SHIBATA Chikashi 東北大学, 大学院・医学系研究科, 准教授 (30270804) ; SASAKI Iwao 東北大学, 大学院・医学系研究科, 教授 (60125557)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 潰瘍性大腸炎 / 回腸嚢炎 / 粘膜免疫機構 / 発症機序 / 潰瘍大腸炎

Research Abstract

In the clinical study, we evaluated the long-term outcome of pouchitis following total proctocolectomy and IPAA for patients with ulcerative colitis. In the basic study, we revealed the effect of IL-23 in the intestinal neuroendocrine and cancer cells.

Research Products

• [Journal Article] Adenocarcinoma associated with perianal fistulas in Crohn's disease (2013)
  • Author(s): Ogawa H, Haneda S, Shibata C, Miura K, Nagao M, Ohnuma S, Kohyama A, Unno M.
  • Journal Title: Anticancer Res Volume: 33(2) Pages: 685-9
• [Journal Article] Adenocarcinoma associated with perianal fistulas in Crohn's disease (2013)
  • Author(s): Ogawa H
  • Journal Title: Anticancer Res Volume: 33 Pages: 685-689
  • Peer Reviewed
• [Journal Article] A shift from colon- to ileum-predominant bacteria in ileal-pouch feces following total proctocolectomy (2012)
  • Author(s): Hinata M, Kohyama A, Ogawa H, Haneda S, Watanabe K, Suzuki H, Shibata C, Funayama Y, Takahashi K, Sasaki I, Fukushima K.
  • Journal Title: Dig Dis Sci Volume: 57(11) Issue: 11 Pages: 2965-74
  • DOI: 10.1007/s10620-012-2165-9
  • Peer Reviewed
• [Journal Article] A unique variant of afferent limb syndrome after ileal pouch-anal anastomosis: a case series and review of the literature (2012)
  • Author(s): Ogawa H, Haneda S, Watanabe K, Suzuki H, Miura K, Ohnuma S, Sasaki H, Shibata C, Unno M
  • Journal Title: J Gastrointest Surg Volume: 16(8) Issue: 8 Pages: 1581-4
  • DOI: 10.1007/s11605-012-1872-z
  • Peer Reviewed
• [Journal Article] IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma (2012)
  • Author(s): Suzuki H, Ogawa H, Miura K, Haneda S, Watanabe K, Ohnuma S, Sasaki H, Sase T, Kimura S, Kajiwara T, Komura T, Toshima M, Matsuda Y, Shibata C, Sasaki I
  • Journal Title: Oncol Lett Volume: 4(2) Pages: 199-204
• [Journal Article] The long-term clinical course of pouchitis after total proctocolectomy and IPAA for ulcerative colitis (2012)
  • Author(s): Suzuki H, Ogawa H, Shibata C, Haneda S, Watanabe K, Takahashi K, Funayama Y, Sasaki I.
  • Journal Title: Dis Colon Rectum Volume: 55(3) Issue: 3 Pages: 330-6
  • DOI: 10.1097/dcr.0b013e3182417358
  • Peer Reviewed
• [Journal Article] IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma (2012)
  • Author(s): Suzuki H
  • Journal Title: Oncol Lett Volume: 4 Pages: 199-204
  • Peer Reviewed
• [Journal Article] A unique variant of afferent limb syndrome after ileal pouch-anal anastomosis: a case series and review of the literature (2012)
  • Author(s): Ogawa H
  • Journal Title: J Gastrointest Surg Volume: 16 Pages: 1581-1584
  • Peer Reviewed
• [Journal Article] 【潰瘍性大腸炎-長期経過観察例の諸問題】術後長期経過例の推移 (2011)
  • Author(s): 渡辺和宏、小川仁、柴田近, 他
  • Journal Title: 臨床消化器内科 Volume: 26(8) Pages: 1145-1151
• [Journal Article] 難治性潰瘍性大腸炎-診療・治療の新たな展開】主題難治性回腸嚢炎の病態と治療 (2011)
  • Author(s): 福島浩平、小川仁、柴田近, 他
  • Journal Title: 胃と腸 Volume: 46(3) Pages: 2003-2008
• [Journal Article] 回腸嚢炎の診断と分類 (2010)
  • Author(s): 小川仁
  • Journal Title: IBD Research Volume: 4 Pages: 75-80
• [Journal Article] C.Difficile関連難治性回腸嚢炎の3例 (2010)
  • Author(s): 小川仁, ほか
  • Journal Title: 日本消化器外科学会雑誌 Volume: 43 Pages: 270-276
  • Peer Reviewed
• [Presentation] 大腸全摘・回腸嚢肛門吻合術後Afferent Loop Syndromeの検討 (2012)
  • Author(s): 小川仁、柴田近、三浦康、佐々木宏之、羽根田祥、渡辺和宏、鈴木秀幸、海野倫明
  • Organizer: 第67回日本消化器外科学会総会
  • Place of Presentation: 富山
  • Year and Date: 2012-07-19
• [Presentation] IL-23 Regulates Gene Expressions via STAT3 Activation in the Human Intestinal Neuroendocrine Cell Line (2012)
  • Author(s): Suzuki H, Ogawa H, Miura K, Naitoh T, Shibata C
  • Organizer: DDW2012
  • Place of Presentation: アメリカ合衆国(San Diego)
  • Year and Date: 2012-05-22
• [Presentation] IL-23はSTAT3を介して腸管の神経内分泌細胞に作用する (2012)
  • Author(s): 鈴木秀幸、小川仁,三浦康,内藤剛,羽根田祥,渡辺和宏,大沼忍,佐々木宏之,鹿郷昌之,田中直樹,工藤克昌,佐瀬友彦,木村俊一,梶原大輝,小村俊博,戸嶋政秀,松田泰史,柴田近,佐々木巌
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-21
• [Presentation] IL-23は直接的に大腸癌の増殖能・浸潤能を亢進させる (2012)
  • Author(s): 鈴木秀幸、小川仁,三浦康,羽根田祥,渡辺和宏,大沼忍,佐々木宏之,佐瀬友彦,木村俊一,梶原大輝,小村俊博,戸嶋政秀,松田泰史,柴田近,佐々木巖
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2012-04-14
• [Presentation] 潰瘍性大腸炎手術の周術期管理におけるクリニカルパスの使用と成績 (2011)
  • Author(s): 小川仁、柴田近, 他
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-14
• [Presentation] 潰瘍性大腸炎にチアする大腸全摘回腸嚢肛門吻合術後回腸嚢炎の臨床経過 (2010)
  • Author(s): 小川仁, ほか
  • Organizer: 潰瘍病態研究会第19回フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2010-08-21
• [Presentation] 大腸全摘・回腸嚢肛門吻合術後Afferent Loop Syndromeの検討
  • Author(s): 小川 仁
  • Organizer: 第67回日本消化器外科学会総会
  • Place of Presentation: 富山
• [Presentation] IL-23 Regulates Gene Expressions via STAT3 Activation in the Human Intestinal Neuroendocrine Cell Line
  • Author(s): H. Suzuki
  • Organizer: DDW2012
  • Place of Presentation: San Diego, USA
• [Presentation] IL-23はSTAT3を介して腸管の神経内分泌細胞に作用する
  • Author(s): 鈴木 秀幸
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] IL-23は直接的に大腸癌の増殖能・浸潤能を亢進させる
  • Author(s): 鈴木 秀幸
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉