Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Research Abstract |
We previously showed that the down-regulation of cIAP2, which is the gene related to 5-FU resistant, enhanced the activation of caspase 3/7 and apoptosis under exposure to 5-FU. Furthermore, we investigated the antitumor effect on the difference of mode of administration between alternate-day and daily treatment of fluoropyrimidine agent S-1 by using the xenograft mouse models of colorectal cancer. As a result, alternate-day administration group demonstrated more antitumor effect compared to daily administration group. The expression of cIAP2 in alternate-day administration group was inmunohistochemically inhibited compared to that in daily administration group, suggesting that the tumors of alternate-day administration group might efficiently induce apoptosis.
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