Cloning of a splicing variant of EG-VEGF in colorectal cancer.

• Project/Area Number: 22591481
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Fukui
• Principal Investigator: GOI Takanori 福井大学, 医学部附属病院, 講師 (60225638)
• Co-Investigator(Kenkyū-buntansha): YAMAGICHI Akio 福井大学, 医学部, 教授 (10174608)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 大腸癌 / 血管新生因子 / 浸潤 / 転移 / Variant EG-VEGF

Research Abstract

We identified a novel EG-VEGF gene with a splicing pattern different from that of the regular EG-VEGF gene. Comparison of both genes revealed that the variantEG-VEGF products had a structure lacking thirty-six base pair. Variant EG-VEGF protein increased cancer cell invasion. In addition, Variant EG-VEGF mRNA was found to be expressed in liver metastatic lesion , suggesting that it is an important gene for the function of hematogenous metastasis.

Research Products

• [Journal Article] Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines (2013)
  • Author(s): S. Tabata, T. Goi, T. Nakazawa, Y. Kimura, K. Katayama, A. Yamaguchi
  • Journal Title: Oncol Rep Volume: 29 Pages: 459-463
  • Peer Reviewed
• [Journal Article] The expression of integrins is decreased in colon cancer cells treated with polysaccharide K (2013)
  • Author(s): K. Aso, T. Goi, T. Nakazawa, Y. Kimura, Y. Hirono, K. Katayama, A. Yamaguchi
  • Journal Title: Int J Oncol Volume: 42 Pages: 1175-1180
  • Peer Reviewed
• [Journal Article] MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer (2012)
  • Author(s): Y. Fujishima, T. Goi, Y. Kimura, Y. Hirono, K. Katayama, A. Yamaguchi
  • Journal Title: Int J Oncol Volume: 40 Pages: 960-964
  • Peer Reviewed
• [Journal Article] RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line (2011)
  • Author(s): T. Inoue, T. Goi, Y. Hirono, K. Katayama, A. Yamaguchi
  • Journal Title: LoVo. Oncol Res. Volume: 19 Pages: 527-534
  • Peer Reviewed
• [Journal Article] The effectiveness of transverse coloplasty in patients with ultra-lower rectal cancer (2010)
  • Author(s): T. Goi, K. Honda, K. Katayama, A. Yamaguchi
  • Journal Title: Int Surg Volume: 95 Pages: 201-214
  • Peer Reviewed
• [Journal Article] Survivin-3B gene decreases the invasion-inhibitory effect of colon cancer cells with 5-fluorouracil (2010)
  • Author(s): K. Sawai, T. Goi, Y. Hirono, K. Katayama, A. Yamaguchi
  • Journal Title: Oncol Res Volume: 18 Pages: 541-547
  • Peer Reviewed
• [Presentation] 消化器癌における新規血管新生増殖因子:EG-VEGF(endocrine glands-derived-venous endothelial growth factor) の発現と臨床応用への可能性 (2012)
  • Author(s): 五井孝憲,山口明夫 他
  • Organizer: 第112回日本外科学会定期学術集会
  • Year and Date: 2012-04-12
• [Book] 大腸・肛門外科における現況と今後 (2011)
  • Author(s): 山口明夫、五井孝憲
• [Book] 大腸癌(大腸癌の治療戦略:高齢者の StageI-III 大腸癌の治療 (2010)
  • Author(s): 五井孝憲、山口明夫
• [Remarks]
  • URL: http://geka1.med.lab.u-fukui.ac.jp/