Cloning of a splicing variant of EG-VEGF in colorectal cancer.
| Project/Area Number |
22591481
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Fukui |
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Principal Investigator |
GOI Takanori 福井大学, 医学部附属病院, 講師 (60225638)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGICHI Akio 福井大学, 医学部, 教授 (10174608)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 大腸癌 / 血管新生因子 / 浸潤 / 転移 / Variant EG-VEGF |
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| Research Abstract |
We identified a novel EG-VEGF gene with a splicing pattern different from that of the regular EG-VEGF gene. Comparison of both genes revealed that the variantEG-VEGF products had a structure lacking thirty-six base pair. Variant EG-VEGF protein increased cancer cell invasion. In addition, Variant EG-VEGF mRNA was found to be expressed in liver metastatic lesion , suggesting that it is an important gene for the function of hematogenous metastasis.
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Report
(4 results)
Research Products
(10 results)
