Elucidation of the anticancer mechanism of the lysophospholid through the nuclear receptor
Project/Area Number |
22591482
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Shinshu University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 核内受容体 / リゾリン脂質 / 大腸癌 / 大腸がん / ハイドロゲル |
Research Abstract |
Cyclic phosphatidic acid (cPA) is a specific, high-affinity antagonist of PPARγ; however, the molecular mechanism by which cPA inhibits colon cancer proliferation remains to be clarified. Our report indicates that PPARγ is expressed at considerable levels in human colon cancer cell lines. cPA suppressed cell growth and induced DNA condensation through PPARγ inhibition. This report suggests that potential use of cPA in the development of drugs targeting colon cancer and possib ly other types of cancer.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARγ by cyclic phosphatidic acid2010
Author(s)
Tamotsu Tsukahara, Ryoko Tsukahara, Yuko Fujiwara, Juming Yue, Yunhui Cheng, Huazhan Guo, Alyssa Bolen, Chhunxiang Zhang, Louis Balazs, Fabio Re, Guangwei Du, Michael A Frohman, Daniel L. Baker, Abby.L. Parrill, Ayako Uchiyama, Tetsuyuki Kobayashi, Kimiko-Murofushi, and Gabor Tigyi
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Journal Title
Molecular Cell
Volume: 39
Pages: 421-432
URL
Related Report
Peer Reviewed
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