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Influence of mesenchymal stem cells on intestinal tissue engineering combined with Bianchi's procedure using small intestinal submucosa

Research Project

Project/Area Number 22591488
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionYamaguchi University

Principal Investigator

UENO Tomio  山口大学, 医学部附属病院, 講師 (70284255)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords消化管再生医療 / 小腸粘膜下組織 / 間葉系幹細胞 / 小腸伸長術 / 小腸再生 / 短腸症候群 / 再生医療 / 小腸粘膜下層
Research Abstract

Small intestinal submucosa (SIS) is a biodegradable collagen-rich matrix containing functional growth factors. In this study, we investigated the feasibility of SIS in conjunction with mesenchymal stem cells (MSCs) for regeneration of the gastrointestinal tract. Also, we examined the achievability of SIS as a bioscaffold when combined with small intestinal tissue engineering and Bianchi’s procedure. Seeded MSCs provided an enriched environment that supported tissue regeneration by the SIS graft in the engineered stomach. SIS has the potential for use as a scaffold that promotes the formation of a physical and physiological neointestine, which means that our proposal approaches a novel surgical treatment even in patients with short bowel syndrome.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2013 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] 消化管領域における再生医工学胃:小腸粘膜下層を利用した胃再生2011

    • Author(s)
      上野富雄, 他
    • Journal Title

      G.I.Research

      Volume: 9 Pages: 76-81

    • Related Report
      2011 Annual Research Report
  • [Journal Article] In vivo motility evaluation of the grafted gastric wall with small intestinal submucosa2010

    • Author(s)
      Taku Nishimura, Tomio Ueno, et al.
    • Journal Title

      Tissue Engineering : Part A

      Volume: 16 Pages: 1761-1768

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of mesenchymal stem cells on stomach tissue engineering using small intestinal submucosa

    • Author(s)
      Hiroki Nakatsu, Tomio Ueno, Atunori Oga, Mitsuhiro Nakao, Taku Nishimura, Sei Kobayashi, Masaaki Oka
    • Journal Title

      Journal of Tissue Engineering and Retenerative Medicine

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 同種移植片による小腸再生伸長術-SISを用いた小腸壁再生の可能性2013

    • Author(s)
      上野富雄、他
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      マリンメッセ福岡、福岡
    • Year and Date
      2013-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] ブタ小腸粘膜下組織(SIS)に間葉系幹細胞(MSC)を併用した消化管壁再生の検討2013

    • Author(s)
      上野富雄、他
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Canine small intestinal motility grafted with porcine small intestinal subumucosa2012

    • Author(s)
      Tomio Ueno, Mitsuhiro Nakao, Masaaki Oka
    • Organizer
      20th United European Gastroenterology Week
    • Place of Presentation
      Amsterdam RAI. Netherlands
    • Related Report
      2012 Final Research Report
  • [Presentation] Canine small intestinal motility grafted with porcine small intestinal submucosa2012

    • Author(s)
      Tomio UENO
    • Organizer
      20th United European Gastroenterology Week
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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