Influence of mesenchymal stem cells on intestinal tissue engineering combined with Bianchi's procedure using small intestinal submucosa
| Project/Area Number |
22591488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
UENO Tomio 山口大学, 医学部附属病院, 講師 (70284255)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 消化管再生医療 / 小腸粘膜下組織 / 間葉系幹細胞 / 小腸伸長術 / 小腸再生 / 短腸症候群 / 再生医療 / 小腸粘膜下層 |
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| Research Abstract |
Small intestinal submucosa (SIS) is a biodegradable collagen-rich matrix containing functional growth factors. In this study, we investigated the feasibility of SIS in conjunction with mesenchymal stem cells (MSCs) for regeneration of the gastrointestinal tract. Also, we examined the achievability of SIS as a bioscaffold when combined with small intestinal tissue engineering and Bianchi’s procedure. Seeded MSCs provided an enriched environment that supported tissue regeneration by the SIS graft in the engineered stomach. SIS has the potential for use as a scaffold that promotes the formation of a physical and physiological neointestine, which means that our proposal approaches a novel surgical treatment even in patients with short bowel syndrome.
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Report
(4 results)
Research Products
(7 results)
