Evaluation of tight junctions under bacterial translocation for development of treatment
| Project/Area Number |
22591489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 特任教授 (90304047)
KUWAHARA Tomomi 香川大学, 医学部, 教授 (60263810)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | バクテリアルトランスロケーション / タイトジャンクション / パラセルラールート / トールライクレセプター / 腸内細菌叢 / CPT11 / TNFα / NF-κB / NFκB |
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| Research Abstract |
Under bacterial translocation, expressions of inflammatory cytokines (TNFα、NF-κB et al.) and Toll like receptor (TLR) 2, 4 were increased and caused apoptosis. Tight Junction (TJ) protein (Claudin-1・4、Occludin et al.) were decreased. Diversity of microbiome was decreased and Akkermansia, which disturbed intestinal epithelium, was appeared. Herbal medicine (TU-100) decreased inflammatory cytokines and TLR 2, 4 and maintained TJ proteins and diversity of microbiome, which intoruduced Blautia having protective effects of intestinal epithelium.
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Report
(4 results)
Research Products
(30 results)
