The role of neuronal and inducible NOS in the regulation of intestinal apoptosis in fasting and refeeding rat
Project/Area Number |
22591492
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Josai University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
OTAKE Kazuo 城西大学, 薬学部, 助教 (50337482)
伊東 順太 明海大学, 歯学部, 助教 (40609096)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 廃用性腸管粘膜萎縮 / 絶食 / 再摂食 / 誘導型NO合成酵素 / 神経型NO合成酵素 / 廃用性腸管萎縮 / iNOS / nNOS / グルタミン / ROS / アポトーシス / 細胞増殖 / 腸蠕動運動 |
Research Abstract |
To investigate the change and role of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) on decreasing intestinal apoptosis of refeeding after fasting in rats and to define whether the recovery of the intestinal mucosa atrophy by refeeding is associated with the levels of nitric oxide synthases (NOSs) in the jejunum. These results suggest that nNOS-involved control might be present in the regulation of iNOS activity and its-mediated apoptosis in fasting and refeeding.
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Report
(4 results)
Research Products
(10 results)