The role of neuronal and inducible NOS in the regulation of intestinal apoptosis in fasting and refeeding rat

• Project/Area Number: 22591492
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Josai University
• Principal Investigator: UCHIDA Hiroyuki 城西大学, 薬学部, 准教授 (20245195)
• Co-Investigator(Kenkyū-buntansha): OTAKE Kazuo 城西大学, 薬学部, 助教 (50337482) ; 伊東 順太 明海大学, 歯学部, 助教 (40609096)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 廃用性腸管粘膜萎縮 / 絶食 / 再摂食 / 誘導型NO合成酵素 / 神経型NO合成酵素 / 廃用性腸管萎縮 / iNOS / nNOS / グルタミン / ROS / アポトーシス / 細胞増殖 / 腸蠕動運動

Research Abstract

To investigate the change and role of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) on decreasing intestinal apoptosis of refeeding after fasting in rats and to define whether the recovery of the intestinal mucosa atrophy by refeeding is associated with the levels of nitric oxide synthases (NOSs) in the jejunum. These results suggest that nNOS-involved control might be present in the regulation of iNOS activity and its-mediated apoptosis in fasting and refeeding.

Research Products

• [Journal Article] Fasting-induced intestinal apoptosis is mediated by inducible nitric oxide synthase and interferon-r in rat (2010)
  • Author(s): J Ito, H Uchida, et.al
  • Journal Title: Am J Physiol Gastrointest liver Physiol Volume: 298 Pages: 916-926
• [Journal Article] Fasting-induced intestinal apoptosis is mediated by inducible nitric oxide synthase and interferon-γ in rat. (2010)
  • Author(s): J Ito, H Uchida, et.al.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 298
  • NAID: 120005823458
  • Peer Reviewed
• [Presentation] 酸化ストレスを介した絶食時の廃用性腸管粘膜萎縮に対するグルタミンの予防効果 (2013)
  • Author(s): 町田保奈美、内田博之ら
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
• [Presentation] 絶食後再摂食ラットにおける血漿コルチコステロンレベルと糖代謝に対する一酸化窒素の関与 (2012)
  • Author(s): 内田博之
  • Organizer: 日本NO学会
  • Place of Presentation: 神戸
• [Presentation] 絶食後再摂食ラットの腸管粘膜における神経型および誘導型NO合成酵素の相互作用 (2011)
  • Author(s): 内田博之、伊東順太, ら
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: グランシップ等(静岡県)
  • Year and Date: 2011-03-29
• [Presentation] 再摂食による腸管粘膜の回復過程における誘導型NO合成酵素(iNOS)によるアポトーシスの制御 (2011)
  • Author(s): 伊東順太、内田博之, ら
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: グランシップ等(静岡県)
  • Year and Date: 2011-03-29
• [Presentation] 絶食後再摂食ラットの腸管粘膜における神経型および誘導型NO合成酵素の相互作用 (2011)
  • Author(s): 内田博之、伊東順太ら
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: グランシップ(静岡県)
• [Presentation] 再摂食による腸管粘膜の回復過程における誘導型NO合成酵素(iNOS)によるアポトーシスの制御 (2011)
  • Author(s): 伊東順太、内田博之ら
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: グランシップ(静岡県)
• [Presentation] The role of neuronal and inducible NOS in the regulation of intestinal apoptosis in fasting and refeeding rat (2010)
  • Author(s): Ito J, Uchida H, et.al
  • Organizer: The 6th international conference on the biology, chemistry, and therapeutic applications of nitric oxide
  • Place of Presentation: Kyoto international conference center (Kyoto, Japan)
• [Presentation] The role of neuronal and inducible NOS in the regulation of intestinal apoptosis in fasting and refeeding rat. (2010)
  • Author(s): Junta Ito, Hiroyuki Uchida, et.al.
  • Organizer: The 6^<th> International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto International Conference Center(Kyoto, Japan)