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Regeneration of small intestine with ability of absorption and peristalsis using amniotic membrane and amniotic stem cells

Research Project

Project/Area Number 22591496
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionDoshisha University

Principal Investigator

TSUJIMOTO Hiroyuki  同志社大学, 研究開発推進機構, 研究員 (20521272)

Co-Investigator(Kenkyū-buntansha) HAGIWARA Akeo  同志社大学, 生命医科学部, 教授 (90198648)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords小腸大腸肛門外科学 / 再生医学 / 消化管再生 / 羊膜 / 幹細胞
Research Abstract

To overcome the difficulty of regeneration of intestinal epithelial tissues which is the most serious problems for regeneration of fully circular walled intestine with digestion, absorption and peristalsis, we utilized amniotic membrane and amniotic stem cells, which have excellent ability to induce cell and tissue regeneration or pluripotency to differentiate. In the in vitro analysis, the culture on amniotic membrane or co-culture with amniotic stem cells induced the growth and differentiation of the intestinal epithelial cells. However, in the in vivo experiment to reconstruct the intestine using animal models, the intestinal epithelial tissues were not regenerated although the smooth muscle-like tissues were recognized.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (30 results)

All 2013 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (16 results)

  • [Journal Article] The anti-adhesive effect of thermally cross-linked gelatin film and its influence on the intestinal anastomosis in canine models2013

    • Author(s)
      Hiroyuki Tsujimoto, Ayumi Tanzawa, Mari Matoba, Ayumi Hashimoto, Shuko Suzuki, Shinichiro Morita, Yoshito Ikada, Akeo Hagiwara
    • Journal Title

      J Biomed Mater Res Part B

      Volume: 101B Issue: 1 Pages: 99-109

    • DOI

      10.1002/jbm.b.32821

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 消化器系における神経再生:神経再生を用いる直腸癌の新しい手術戦略2012

    • Author(s)
      萩原明於、辻本洋行、阪倉長平、中村達雄
    • Journal Title

      GI Research

      Volume: 20 Pages: 48-55

    • Related Report
      2012 Final Research Report
  • [Journal Article] The biological properties of the alkari- treated collagen and gelatin -A preliminary study of their influence on cell growth when used as scaffolds-2012

    • Author(s)
      Chiko Yoshida, Ayumi Tanzawa, Atsushi Tamura, Junki Ikeda, Taichi Orikasa, Hideki Takamori, Shinichiro Morita, Hiroyuki Tsujimoto, Akeo Hagiwara
    • Journal Title

      同志社大学理工学研究報告

      Volume: 53 Pages: 7-12

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The biological properties of the alkari-treated collagen and gelatin and gelatin -A preliminary study of their influence on cell growth when used as scaffolds-.2012

    • Author(s)
      Chiko Yoshida, Ayumi Tanzawa, Atsushi Tamura, Junki Ikeda, Taichi Orikasa, Hideki Takamori, Shinichiro Morita, Hiroyuki Tsujimoto, Akeo Hagiwara
    • Journal Title

      同志社大学 理工学研究報告雑誌

      Volume: 53(3) Pages: 7-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 消化器系における神経再生:神経再生を用いる直腸癌の新しい手術戦略2012

    • Author(s)
      萩原明於、辻本洋行、阪倉長平、中村達雄
    • Journal Title

      G I Research

      Volume: 20(6) Pages: 48-55

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 新規癒着防止材熱架橋ゼラチンフィルムの物理的・生物化学的特性-癒着防止効果の機序及び腸管吻合部への影響に対する基礎的検討2011

    • Author(s)
      丹澤あゆみ、辻本洋行、的場麻里、橋本歩、鈴木周子、森田真一郎、筏義人、萩原明郎
    • Journal Title

      同志社大学理工学研究報告

      Volume: 52 Pages: 149-155

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration and functional recovery of intrapelvic nerves removed during extensive surgery by a new artificial nerve conduit: A breakthrough to radical operation for locally advanced and recurrent rectal cancers2011

    • Author(s)
      Hiroyuki Tsujimoto, Tatsuo Nakamura, Tsuneharu Miki, Toshikazu Kubo, Eigo Otsuji, Hisakazu Yamagishi, Akeo Hagiwara
    • Journal Title

      J Gastrointest Surg

      Volume: 15 Pages: 1035-1042

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endocrine differentiation of rat enterocytes in long-term three- dimensional co-culture with intestinal myofibroblasts2011

    • Author(s)
      Tetsuji Yoshikawa, Shinichi Hamada, Eigo Otsuji, Hiroyuki Tsujimoto, Akeo Hagiwara
    • Journal Title

      In Vitro Cell Dev Biol-Animal

      Volume: 47 Pages: 707-715

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration and Functional Recovery of Intrapelvic Nerves Removed During Extensive Surgery by a New Artificial Nerve Conduit : A Breakthrough to Radical Operation for Locally Advanced and Recurrent Rectal Cancers2011

    • Author(s)
      Tsujimoto H, Nakamura T, Miki T, Kubo T, Otsuji E, Yamagishi H, Hagiwara A
    • Journal Title

      J Gastrointest Surg

      Volume: 15 Pages: 1035-1042

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel ant adhesive material, alginate flakes, ex vivo and in vivo2011

    • Author(s)
      Hirasaki, Y., Fukunaga, M., Kidokoro, A., Hashimoto, A., Nakamura, T., Tsujimoto, H., Hagiwara, A.
    • Journal Title

      Surg today

      Volume: 41 Issue: 7 Pages: 970-977

    • DOI

      10.1007/s00595-010-4410-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新規癒着防止材熱架橋ゼラチンフィルムの物理的・生物学的特性2011

    • Author(s)
      丹澤あゆみ、辻本洋行、萩原明郎, 他
    • Journal Title

      同志社大学理工学研究報告

      Volume: 52(2) Pages: 150-155

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Regeneration and Functional Recovery of Intrapelvic Nerves Removed During Extensive Surgery by a New Artificial Nerve Conduit : A Breakthrough to Radical Operation for Locally Advanced and Recurrent Rectal Cancers.2011

    • Author(s)
      Tsujimoto H, Nakamura T, Miki T, Kubo T, Otsuji E, Yamagishi H, Hagiwara A.
    • Journal Title

      Journal of Gastrointestinal Surgery

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel anti-adhesive material, alginate flakes, ex vivo and in vivo2011

    • Author(s)
      Hirasaki Y, Tsujimoto H, Hagiwara A, et al.
    • Journal Title

      Surgery Today

      Volume: (掲載確定)

    • NAID

      10029048751

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自動縫合器を用いた肺部分切除におけるポリグリコール酸不織布の空気漏れ防止効果の犬における検討2010

    • Author(s)
      橋本歩、平崎憲範、辻本洋行、丹澤あゆみ、的場麻理、桑原正樹、萩原明郎
    • Journal Title

      日本気胸・嚢胞性肺疾患学会誌

      Volume: 10(2) Pages: 92-95

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規癒着防止材熱架橋gelatin filmの生物学的特性 -熱架橋度と癒着防止効果の関係について-2012

    • Author(s)
      辻本洋行、、丹澤あゆみ、吉田千子、筏義人、萩原明郎
    • Organizer
      DDWJ
    • Place of Presentation
      神戸市
    • Year and Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 再生の足場材料を用いた癒着防止材 -腹膜の再生と消化管吻合部への影響2012

    • Author(s)
      辻本洋行、丹澤あゆみ、鈴木周子、筏義人、萩原明郎
    • Organizer
      日本消化器外科学会
    • Place of Presentation
      富山市
    • Year and Date
      2012-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 再生の足場材料を用いた癒着防止材 -熱架橋gelatin filmによる腹膜の再生と消化管吻合部への影響-2012

    • Author(s)
      辻本洋行、丹澤あゆみ、吉田千子、筏義人、萩原明郎
    • Organizer
      日本再生医療学会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-06-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 架橋gelatin filmの癒着防止効果と消化管吻合部への影響 -その腹膜再生効果と物理的生物学的特性について-2012

    • Author(s)
      辻本洋行、丹澤あゆみ、橋本歩、筏義人、萩原明郎
    • Organizer
      日本外科学会
    • Place of Presentation
      千葉市
    • Year and Date
      2012-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 架橋gelatin filmの癒着防止効果と消化管吻合部への影響 -その腹膜再生効果と物理的・生物学的特性について-2011

    • Author(s)
      辻本洋行、丹澤あゆみ、橋本歩、筏義人、萩原明郎
    • Organizer
      DDWJ
    • Place of Presentation
      博多市
    • Year and Date
      2011-10-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 熱架橋gelatin filmを用いた癒着防止と消化管吻合部への影響2011

    • Author(s)
      辻本洋行、萩原明郎, 他
    • Organizer
      第9回日本消化器外科学会大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 熱架橋gelatin filmを用いた癒着防止と腹膜再生2011

    • Author(s)
      辻本洋行、萩原明郎, 他
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-03-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 熱架橋gelatin filmを用いた癒着防止と腹膜再生2011

    • Author(s)
      辻本洋行、丹澤あゆみ、橋本歩、筏義人、萩原明郎
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京都
    • Year and Date
      2011-03-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 熱架橋gelatin filmを用いた癒着防止と消化管吻合部への影響2011

    • Author(s)
      辻本洋行、丹澤あゆみ、橋本歩、筏義人、萩原明郎
    • Organizer
      日本外科学会
    • Place of Presentation
      誌上開催
    • Related Report
      2012 Final Research Report
  • [Presentation] 熱架橋gelatin filmを用いた癒着防止と消化管吻合部への影響2011

    • Author(s)
      辻本洋行、萩原明郎, 他
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      (誌上発表)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 熱架橋gelatin filmを用いた癒着防止と腹膜再生2010

    • Author(s)
      辻本洋行、萩原明郎, 他
    • Organizer
      第8回消化器外科学会大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 架橋gelatin filmを用いた癒着防止と腹膜再生2010

    • Author(s)
      辻本洋行、丹澤あゆみ、橋本歩、筏義人、萩原明郎
    • Organizer
      DDWJ.
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 熱架橋gelatin filmの癒着防止効果と消化管吻合部への影響 -その腹膜再生効果と物理的・生物学的特性について-.

    • Author(s)
      辻本洋行、丹澤あゆみ、橋本歩、的場麻理、吉田千子、竹本洋一、石橋治昭、鈴木周子、森田真一郎、筏義人、萩原明郎
    • Organizer
      第112回 日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 再生の足場材料を用いた癒着防止材 –熱架橋gelatin filmによる腹膜の再生と消化管吻合部への影響-.

    • Author(s)
      辻本洋行、丹澤あゆみ、折笠太一、池田潤基、吉田千子、鳥井裕子、御座本雄軌、竹本洋一、鈴木周子、平嗣良、森田真一郎、筏義人、萩原明郎
    • Organizer
      第11回 日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 再生の足場材料を用いた癒着防止材 –腹膜の再生と消化管吻合部への影響-.

    • Author(s)
      辻本洋行、丹澤あゆみ、折笠太一、池田潤基、御座本雄軌、竹本洋一、鈴木周子、森田真一郎、筏義人、萩原明郎
    • Organizer
      第67回 日本消化器外科学会総会
    • Place of Presentation
      富山国際会議場(富山県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規癒着防止材熱架橋gelatin filmの生物学的特性 -熱架橋度と癒着防止効果の関係について-.

    • Author(s)
      辻本洋行、丹澤あゆみ、吉田千子、堀井常人、宮本博恵、安部里恵、折笠太一、池田潤基、鳥井裕子、御座本雄軌、鈴木周子、森田真一郎、筏義人、萩原明郎
    • Organizer
      第10回 日本消化器外科学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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