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Study of the causative alterations of the base excision repair gene MUTYH on the carcinogenesis of sporadic colorectal cancer and of the possible clinical applications.

Research Project

Project/Area Number 22591497
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionHyogo Medical University

Principal Investigator

KUNO Takashi  兵庫医科大学, 医学部, 助教 (30441281)

Co-Investigator(Kenkyū-buntansha) MATSUBARA Nagahide  兵庫医科大学, 医学部, 准教授 (70314672)
TAMURA Kazuo  近畿大学, 理工学部, 教授 (20278823)
TOMITA Naoihiro  兵庫医科大学, 医学部, 教授 (00252643)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords大腸癌 / MYH / 発癌 / 修復遺伝子 / colorectal cancer / MUTYH / base excision repair / loss of herozygosity / KRAS
Research Abstract

The base excision repair gene MUTYH encodes glycosylase which removes adenine residues mispaired with 8-OHG. Biallelic germline mutation of the MUTYH gene are known to cause multiple colorectal adenomas including polyposis and cancer, mostly due to G:C→T:A transversions in proto-ongogenes or tumor suppressor genes. To investigate the possible role of MUTYH mutation in sporadic colorectal cancer (CRC), we examined alterations of the MUTYH gene including somatic mutations and allelic loss in sporadic CRC. MUTYH mutations in cancer DNA were detected in 3 cases, while mutations were also found in DNA samples from the normal tissue, indicating that all were germline mutations. In conclusion, somatic alterations of MUTYH in sporadic CRC were rare, similar to other DNA repair genes.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results)

  • [Journal Article] Alterations of the base excision repair gene MUTYH in sporadic colorectal cancer.2012

    • Author(s)
      Takashi Kuno, Nagahide Matsubara, Satoshi Tsuda, Masayoshi Kobayashi, Mie Hamanaka, Daisuke Yamagishi, Kiyoshi Tsukamoto, Tomoki Yamano, Masafumi Noda, Hiroki Ikeuchi, Sanghyuk Kim, Kazuo Tamura, and Naohiro Tomita
    • Journal Title

      Oncol. Rep.

      Volume: 28 Pages: 473-480

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic regulation and colorectal cancer.2012

    • Author(s)
      Nagahide Matsubara
    • Journal Title

      Dis. Colon Rec.

      Volume: 55 Pages: 96-104

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大腸癌におけるプロモーターのメチル化と2010

    • Author(s)
      松原長秀
    • Journal Title

      CIMP 癌と化学療法

      Volume: 37 (9) Pages: 1569-1664

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 大腸腺腫及び散在性大腸癌における塩基除去修復遺伝子MUTYH遺伝子異常の関与2012

    • Author(s)
      田村和朗、金相赤赤、喜多瑞穂、石川真澄、伊田和史、久野隆史、山野智基、松原長秀、冨田尚裕
    • Organizer
      第23回日本消化器癌発生学会総会
    • Place of Presentation
      鳴門
    • Related Report
      2012 Final Research Report
  • [Presentation] 散在性大腸癌における塩基除去修復遺伝子であるMUTYH遺伝子の変化2012

    • Author(s)
      久野隆史、松原長秀、津田聰司、小林政義、濱中美衣、山岸大介、塚本潔、山野智基、野田雅史、池内浩基、田村和朗、冨田尚裕
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 大腸腺腫及び散在性大腸癌における塩基除去修復遺伝子MUTYH遺伝子異常の関与2012

    • Author(s)
      田村和朗、金相赤赤、喜多瑞穂、石川真澄、伊田和史、久野隆史、山野智基、松原長秀、冨田尚裕
    • Organizer
      第23回日本消化器癌発生学会総会
    • Place of Presentation
      徳島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大腸癌発生における塩基除去修復遺伝子MYHの関与2011

    • Author(s)
      久野隆史、松原長秀、津田聰司、馬場谷彰仁、濱中美衣、山岸大介、塚本潔、山野智基、野田雅史、吉澤恵、田村和朗、冨田尚裕
    • Organizer
      第17回日本家族性腫瘍学会学術集会(遺伝医学合同学術集会2011)
    • Place of Presentation
      京都大学百周年時計台記念館
    • Related Report
      2012 Final Research Report
  • [Presentation] 大腸癌発生における塩基除去修復遺伝子MYHの関与2011

    • Author(s)
      久野隆史、松原長秀、津田聴司、馬場谷彰仁、濱中美衣、山岸大介、塚本潔、山野智基、野田雅史、吉澤恵、田村和朗、冨田尚裕
    • Organizer
      第17回日本家族性腫瘍学会学術集会(遺伝医学合同学術集会)
    • Place of Presentation
      京都大学百周年時計台記念館
    • Related Report
      2011 Annual Research Report
  • [Presentation] 散在性ならびに多発性腫瘍発生における塩基除去修復遺伝子MYHの関与2010

    • Author(s)
      久野隆史
    • Organizer
      日本家族性腫瘍学会
    • Place of Presentation
      朱鷺メッセ
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 散在性ならびに多発性腫瘍発生における塩基除去修復遺伝子MYHの関与2010

    • Author(s)
      久野隆史、松原長秀、津田聡司、浜田美衣、山岸大介、塚本潔、野田雅史、西上隆之、金友英、田村和朗、冨田尚裕
    • Organizer
      第16回日本家族性腫瘍学会学術集会
    • Place of Presentation
      新潟
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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