Research and development of liver regeneration with autologous bone marrow cell transplantation against the limitation of major hepatectomy

• Project/Area Number: 22591498
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Jichi Medical University (2012); Tohoku University (2010-2011)
• Principal Investigator: RIKIYAMA Toshiki 自治医科大学, 医学部, 教授 (80343060)
• Co-Investigator(Kenkyū-buntansha): HAYASHI Hiroki 東北大学, 大学病院, 助教 (30422124) ; UNNO Michiaki 東北大学, 医学(系)研究科(研究院), 教授 (70282043)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 骨髄幹細胞 / 肝再生 / 大量肝切除 / 自家骨髄細胞移植

Research Abstract

We intraperitoneally-administered carbon tetrachloride (CCl4) tosevere immunodeficient mouse (NOG mouse) and created chronic liver injury modeland hepatic failure model. We transplanted bone marrow cells of GFP-positive NOG mice into tail vein, small numb

Research Products

• [Journal Article] Potential Utility of NOG Mice with Ubiquitous eGFP Expression (NOG-EGFP) as a High Quality Cancer Sampling System (2012)
  • Author(s): Shima K, Mizuma M, Hayashi H, Nakagawa K, Okada T, Sakata N, Omura N, Kitamura Y, Motoi F, Naito T, Rikiyama T, Katayose Y, Egawa S, Ishii N, Horii A, Unno M
  • Journal Title: J Exp Clin Cancer Res. Volume: 31(1)
• [Presentation] 蛍光 NOG マウスの異種移植モデルを用いた高純度癌細胞サンプリングシステム (2013)
  • Author(s): 嶋健太郎,水間正道, 林 洋毅, 中川 圭, 岡田恭穂, 坂田直昭, 大村範幸, 北村 洋, 吉田 寛, 元井冬彦, 力山敏樹, 片寄 友, 江川新一, 石井直人, 堀井 明 , 海野倫明
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] Utility of xenograft models using NOG-eGFP mice for a high quality sampling system of Pancreato-Biliary cancer cells (2012)
  • Author(s): Shima K,Mizuma M, Rikiyama T, Katayose Y, Egawa S, Ishii N, Horii A, Unno M
  • Organizer: IHPBA 2012
  • Place of Presentation: Paris
• [Presentation] An attempt to establish a high quality sampling system of cancer cells using a xenograft model of NOG-EGFP mice. (2011)
  • Author(s): 嶋健太郎,水間正道, 大村範幸, 林 洋毅, 中川 圭, 岡田恭穂, 元井冬彦, 力山敏樹, 片寄 友, 江川新一, 石井直人, 堀井 明, 海野倫明
  • Organizer: 第70回日本癌学会学術集会
  • Place of Presentation: 名古屋