Prevention of ischemia-reperfusion liver injury through inhibiting the Platelets-Kuppfer cell interaction
| Project/Area Number |
22591499
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KONDO Tadashi 筑波大学, 医学医療系, 准教授 (00375495)
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| Co-Investigator(Kenkyū-buntansha) |
OHKOHCHI Nobuhiro 筑波大学, 医学医療系, 教授 (40213673)
FUKUNAGA Kiyoshi 筑波大学, 医学医療系, 講師 (20361339)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肝臓外科学 / 肝虚血再灌流 / 肝微小循環 / 肝虚血再潅流 |
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| Research Abstract |
Hepatic ischemiaereperfusion (I/R) leads to activation of Kupffer cells (KCs). We have evaluate the interaction between platelets and KCs in the hepatic microcirculation after I/R. In the I/R group, the number of adherent platelets increased significantly after I/R. More than 50% of the adherent platelets adhered to KCs. We succeeded in visualizing the dynamics of both KCs and platelets in the hepatic sinusoids. Liver ischemia induced the adhesion of platelets to KCs in the early period, which could play a key role in reperfusion injury of the liver.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] 肝侵襲後の類洞内血球動態2011
Author(s)
田村孝史, 近藤匡, 朴秀吉, 中野順隆, 村田聡一郎, 福永潔, 寺島秀夫, 大河内信弘
Organizer
日本外科代謝栄養学会第48回学術集会
Place of Presentation
名古屋国際会議場
Related Report
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