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Prevention of ischemia-reperfusion liver injury through inhibiting the Platelets-Kuppfer cell interaction

Research Project

Project/Area Number 22591499
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

KONDO Tadashi  筑波大学, 医学医療系, 准教授 (00375495)

Co-Investigator(Kenkyū-buntansha) OHKOHCHI Nobuhiro  筑波大学, 医学医療系, 教授 (40213673)
FUKUNAGA Kiyoshi  筑波大学, 医学医療系, 講師 (20361339)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肝臓外科学 / 肝虚血再灌流 / 肝微小循環 / 肝虚血再潅流
Research Abstract

Hepatic ischemiaereperfusion (I/R) leads to activation of Kupffer cells (KCs). We have evaluate the interaction between platelets and KCs in the hepatic microcirculation after I/R. In the I/R group, the number of adherent platelets increased significantly after I/R. More than 50% of the adherent platelets adhered to KCs. We succeeded in visualizing the dynamics of both KCs and platelets in the hepatic sinusoids. Liver ischemia induced the adhesion of platelets to KCs in the early period, which could play a key role in reperfusion injury of the liver.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2013 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (16 results)

  • [Journal Article] Influence of Kupffer cells and platelets on ischemia-reperfusion injury in mild steatotic liver2013

    • Author(s)
      Ogawa K, Kondo T, Tamura T, Matsumura H, Fukunaga K, Oda T, Ohkohchi N
    • Journal Title

      World J Gastroenterol.

      Volume: 19(9) Issue: 9 Pages: 1396-404

    • DOI

      10.3748/wjg.v19.i9.1396

    • NAID

      120007137022

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of heme oxygenase-1 on hepaticischemia-reperfusion injury throughinhibition of platelet adhesion to the sinusoids2012

    • Author(s)
      Tamura T, Kondo T, Ogawa K, Fukunaga K, Ohkohchi N.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 28(4) Issue: 4 Pages: 700-6

    • DOI

      10.1111/jgh.12075

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between Kupffer cells and platelets in the early period of hepatic ischemia-reperfusion injury--an in vivo study2012

    • Author(s)
      Tamura T, Kondo T, Pak S, NakanoY, Murata S, Fukunaga K, Ohkohchi N
    • Journal Title

      J Surg Res

      Volume: 178(1) Issue: 1 Pages: 443-51

    • DOI

      10.1016/j.jss.2011.12.010

    • NAID

      120007137160

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between Kupffer cells and platelets in the early period of hepatic ischemia-reperfusion injury-An in vivo study2012

    • Author(s)
      Tamura T, Kondo T, Pak S, Nakano Y, Murata S, Fukunaga K, Ohkohchi N
    • Journal Title

      Journal of SurgicalResearch

      Volume: (in press)

    • NAID

      120007137160

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion2010

    • Author(s)
      Pak S, Kondo T, Nakano Y, MurataS, Fukunaga K, Oda T, Sasaki R, Ohkohchi N
    • Journal Title

      Platelets.

      Volume: 21(4) Issue: 4 Pages: 282-8

    • DOI

      10.3109/09537101003637265

    • NAID

      120007130823

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion.2010

    • Author(s)
      S Paku, T Kondo, Y Nakano, S Murata, K Fukunaga, T Oda, R Sasaki, N Ohkohchi.
    • Journal Title

      Platelets

      Volume: 21(4) Pages: 283-288

    • NAID

      120007130823

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] The influence of the milddegree steatotic liver in ischemia reperfusion injury.2012

    • Author(s)
      Ogawa K.
    • Organizer
      The 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists.
    • Place of Presentation
      バンコク(タイ)
    • Related Report
      2012 Final Research Report
  • [Presentation] Kupffer細胞と血小板の類洞内動態に着目した軽度脂肪肝における肝虚血再潅流障害の検討2012

    • Author(s)
      小川光一
    • Organizer
      第19回幹細胞研究会
    • Place of Presentation
      札幌医科大学(札幌)
    • Related Report
      2012 Final Research Report
  • [Presentation] 軽度脂肪肝における肝虚血再潅流障害は正常肝に比べて軽度である2012

    • Author(s)
      小川光一
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      石川県立音楽堂(金沢)
    • Related Report
      2012 Final Research Report
  • [Presentation] The influence of the mild degree steatotic liver in ischemia reperfusion injury2012

    • Author(s)
      小川 光一
    • Organizer
      The 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
    • Place of Presentation
      バンコク(タイ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 軽度脂肪肝における肝虚血再潅流障害は正常肝に比べて軽度である2012

    • Author(s)
      小川光一
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      石川県立音楽堂(金沢)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Kupffer細胞と血小板の類洞内動態に着目した軽度脂肪肝における肝虚血再潅流障害の検討2012

    • Author(s)
      小川光一
    • Organizer
      第19回肝細胞研究会
    • Place of Presentation
      札幌医科大学(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo evidence of interaction between Kupffer cells and platelets in the early period of hepatic ischemia-reperfusion injury2011

    • Author(s)
      Tamura T.
    • Organizer
      IASGO
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝虚血再潅流後のKupffer細胞と血小板の類洞内動態の解明2011

    • Author(s)
      田村孝史
    • Organizer
      第18回幹細胞研究会
    • Place of Presentation
      東京ガーデンパレス(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝侵襲後の類洞内血球動態2011

    • Author(s)
      田村孝史
    • Organizer
      日本外科代謝栄養学会第48回各術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Final Research Report
  • [Presentation] Hemeoxygenase-1による虚血再潅流障害予防メカニズムの解明2011

    • Author(s)
      田村孝史
    • Organizer
      第47回日本肝臓学会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝虚血再潅流時のKupffer細胞と血小板の動態の解明2011

    • Author(s)
      田村孝史
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] In vivo evidence of interaction between Kupffer cells and platelets in the early period of hepatic ischemia-reperfusion injury2011

    • Author(s)
      Tamura T, Kondo T, Ogawa K, Pak S, Murata S, Fukunaga K, Ohokohchi N
    • Organizer
      IASGO 2011
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝虚血再潅流後のKupffer細胞と血小板の類洞内動態の解明2011

    • Author(s)
      田村孝史, 近藤匡, 小川光一, 朴秀吉, 中野順隆, 村田聡一郎, 福永潔, 大河内信弘
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hemeoxygenase-1による虚血再潅流障害予防メカニズムの解明2011

    • Author(s)
      田村孝史, 近藤匡, 朴秀吉, 村田聡一郎, 福永潔, 大河内信弘
    • Organizer
      第47回日本肝臓学会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝侵襲後の類洞内血球動態2011

    • Author(s)
      田村孝史, 近藤匡, 朴秀吉, 中野順隆, 村田聡一郎, 福永潔, 寺島秀夫, 大河内信弘
    • Organizer
      日本外科代謝栄養学会第48回学術集会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝虚血再潅流時のKupffer細胞と血小板の動態の解明2011

    • Author(s)
      田村孝史, 近藤匡, 朴秀吉, 村田聡一郎, 福永潔, 大河内信弘
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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