A new perspective for extending use of steatotic liver graft by analyzing for phosphorylation signaling pathway and applying for endothelial progenitor cells.
| Project/Area Number |
22591500
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Masaru 千葉大学, 大学院・医学研究院, 教授 (70166156)
KIMURA Fumio 千葉大学, 大学院・医学研究院, 特任教授 (70334208)
TAKEUCHI Dan 千葉大学, 医学部附属病院, 助教 (20400822)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脂肪肝 / 生体部分肝移植 / 肝再生 / リン酸化シグナル / 肝不全 / 阻血再灌流障害 / メタボリックシンドローム / adipocytokine / 生体肝移植 / 再灌流障害 / メタボリック・シンドローム / 肝切除 |
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| Research Abstract |
The steatotic liver is vulnerable to hepatic ischemia/reperfusion, leading to significant hepatocyte apoptosis by the mitochondrial permeability transition, and thereby resulting in organ dysfunction. In addition, regeneration of the steatotic liver after extended hepatectomy is impaired by a decrease in ATP levels and a decrease in activation of phosphorylation of survival signal.
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Report
(4 results)
Research Products
(15 results)
