Clinical heterogeneity brought about by tumor-initiating cells in primary liver cancer and the development of new therapeutic strategy by regulating microRNAs.
| Project/Area Number |
22591501
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Masaru 千葉大学, 大学院・医学研究院, 教授 (70166156)
SHIMIZU Hiroaki 千葉大学, 大学院・医学研究院, 准教授 (80272318)
YOSHITOMI Hideyuki 千葉大学, 大学院・医学研究院, 助教 (60375631)
林 達也 千葉大学, 医学部附属病院, 医員 (90568619)
高野 重紹 千葉大学, 医学部附属病院, 助教 (20436380)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 癌源細胞 / 肝細胞癌 / 肝内胆管癌 / 組織幹細胞 / 表面マーカー / 分化 / マイクロRNA / 原発性肝癌 |
|---|
| Research Abstract |
Hepatocellular carcinomas could not be classified according to their phenotypic expression, since there were diverse patterns. In contrast, in intrahepatic cholangiocarcinomas, Notch2 was expressed in 56% of cases. Although Notch2 expression was inversely correlated with CD44 expression, this expression was significantly associated with c-Kit expression, suggesting that intrahepatic cholangiocarcinoma with positive Notch2 expression might be derived from hepatic progenitor cells. Survival among patients with positive Notch2 expression was significantly better than that among patients with negative Notch2 expression, indicating that Notch2 expression might have a connection with clinical behavior of intrahepatic cholangiocarcinomas. The expressions of MUC1 and MUC2, as well as p53, in intraductal papillary neoplasms of the bile duct were found to be different from those in conventional intrahepatic cholangiocarcinomas.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells2012
Author(s)
Kagawa S, Takano S, Yoshitomi H, Kimura F, Satoh M, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Furukawa K, Matsushita K, Nomura F, Miyazaki M
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Journal Title
T Surg Res
Volume: 178
Issue: 2
Pages: 758-767
DOI
Related Report
Peer Reviewed
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[Journal Article] CO Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion2011
Author(s)
Ohtsuka M, Kimura F, Shimizu H, Yoshidome H, Kato A, Yoshitomi H, Furukawa K, Takeuchi D, Takayashiki T, Suda K, Takano S, Kondo Y, Miyazaki M
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Journal Title
Am Surg Pathol
Volume: 35
Pages: 512-521
Related Report
Peer Reviewed
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[Journal Article] Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer2010
Author(s)
Takano S, Sogawa K, Yoshitomi H, Shida T, Mogushi K, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Ishihara T, Tanaka H, Yokosuka 0, Nomura F, Miyazaki M
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Journal Title
Br J Cancer
Volume: 103
Pages: 223-231
Related Report
Peer Reviewed
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