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Clinical heterogeneity brought about by tumor-initiating cells in primary liver cancer and the development of new therapeutic strategy by regulating microRNAs.

Research Project

Project/Area Number 22591501
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionChiba University

Principal Investigator

OHTSUKA Masayuki  千葉大学, 大学院・医学研究院, 講師 (90334185)

Co-Investigator(Kenkyū-buntansha) MIYAZAKI Masaru  千葉大学, 大学院・医学研究院, 教授 (70166156)
SHIMIZU Hiroaki  千葉大学, 大学院・医学研究院, 准教授 (80272318)
YOSHITOMI Hideyuki  千葉大学, 大学院・医学研究院, 助教 (60375631)
林 達也  千葉大学, 医学部附属病院, 医員 (90568619)
高野 重紹  千葉大学, 医学部附属病院, 助教 (20436380)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords癌源細胞 / 肝細胞癌 / 肝内胆管癌 / 組織幹細胞 / 表面マーカー / 分化 / マイクロRNA / 原発性肝癌
Research Abstract

Hepatocellular carcinomas could not be classified according to their phenotypic expression, since there were diverse patterns. In contrast, in intrahepatic cholangiocarcinomas, Notch2 was expressed in 56% of cases. Although Notch2 expression was inversely correlated with CD44 expression, this expression was significantly associated with c-Kit expression, suggesting that intrahepatic cholangiocarcinoma with positive Notch2 expression might be derived from hepatic progenitor cells. Survival among patients with positive Notch2 expression was significantly better than that among patients with negative Notch2 expression, indicating that Notch2 expression might have a connection with clinical behavior of intrahepatic cholangiocarcinomas. The expressions of MUC1 and MUC2, as well as p53, in intraductal papillary neoplasms of the bile duct were found to be different from those in conventional intrahepatic cholangiocarcinomas.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 6 results) Presentation (10 results) Book (1 results)

  • [Journal Article] 「胆膵癌の早期診断フロントライン」 胆道(胆嚢、胆管) 臨床 切除例からみた考察2013

    • Author(s)
      大塚将之
    • Journal Title

      肝・胆・膵

      Volume: 66 Pages: 221-226

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells2012

    • Author(s)
      Kagawa S, Takano S, Yoshitomi H, Kimura F, Satoh M, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Furukawa K, Matsushita K, Nomura F, Miyazaki M
    • Journal Title

      T Surg Res

      Volume: 178 Issue: 2 Pages: 758

    • DOI

      10.1016/j.jss.2012.05.065

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 「いわゆる良性腫瘍のマリグナントプログレッション」胆道系腫瘍:大型胆管・付属腺での良性腫瘍/低異型度悪性腫瘍と癌化胆管内乳頭状腫瘍(IPNB)診断・病理2012

    • Author(s)
      大塚将之、清水宏明、吉留博之、加藤厚、古川勝規、吉富秀幸、竹内男、高屋敷吏、久保木知、鈴木大亮、中島正之、相田俊明、宮崎勝
    • Journal Title

      肝・胆・膵

      Volume: 65 Pages: 471-478

    • Related Report
      2012 Final Research Report
  • [Journal Article] 「いわゆる良性腫瘍のマリグナントプログレッション」胆道系腫瘍:大型胆管・付属腺での良性腫瘍/低異型度悪性腫瘍と癌化 胆管内乳頭状腫瘍(IPNB) 診断・病理2012

    • Author(s)
      大塚将之
    • Journal Title

      肝・胆・膵

      Volume: 65 Pages: 471-478

    • Related Report
      2012 Annual Research Report
  • [Journal Article] CXCR4/CXCL12 expression profile is associated with tumor microenvironment and clinical outcome of liver metastases of colorectal cancer2011

    • Author(s)
      Sakai N, et al.
    • Journal Title

      Clin Exp metastasis

      Volume: 29 Issue: 2 Pages: 101

    • DOI

      10.1007/s10585-011-9433-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CO Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion2011

    • Author(s)
      Ohtsuka M, Kimura F, Shimizu H, Yoshidome H, Kato A, Yoshitomi H, Furukawa K, Takeuchi D, Takayashiki T, Suda K, Takano S, Kondo Y, Miyazaki M
    • Journal Title

      Am Surg Pathol

      Volume: 35 Pages: 512-521

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 「肝内胆管、胆道、膵の腫瘍分類:WHOの新たな試みを含めて」肝内胆管・胆道IPNB:粘液産生性、非産生性を含めて2011

    • Author(s)
      大塚将之、木村文夫、清水宏明、吉留博之、加藤厚、吉富秀幸、竹内男、古川勝規、高屋敷吏、須田浩介、久保木知、宮崎勝
    • Journal Title

      肝・胆・膵

      Volume: 62 Pages: 133-140

    • Related Report
      2012 Final Research Report
  • [Journal Article] Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion2011

    • Author(s)
      Ohtsuka M, et al
    • Journal Title

      Am J Surg Pathol

      Volume: 35 Issue: 4 Pages: 512

    • DOI

      10.1097/pas.0b013e3182103f36

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「肝内胆管、胆道、膵の腫瘍分類:WHOの新たな試みを含めて」肝内胆管・胆道 IPNB:粘液産生性、非産生性を含めて2011

    • Author(s)
      大塚将之, 他
    • Journal Title

      肝胆膵

      Volume: 62 Pages: 133-140

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer2010

    • Author(s)
      Takano S, Sogawa K, Yoshitomi H, Shida T, Mogushi K, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Ishihara T, Tanaka H, Yokosuka 0, Nomura F, Miyazaki M
    • Journal Title

      Br J Cancer

      Volume: 103 Pages: 223-231

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 「膵癌・胆道癌の前癌病変、リスクファクターを探る」胆道癌発癌の病理学的および分子生物学的メカニズム2010

    • Author(s)
      大塚将之、木村文夫、清水宏明、吉留博之、加藤厚、吉富秀幸、竹内男、古川勝規、高屋敷吏、須田浩介、高野重紹、久保木知、宮崎勝
    • Journal Title

      胆と膵

      Volume: 31 Pages: 169-175

    • Related Report
      2012 Final Research Report
  • [Journal Article] Surgical strategy for mucin-producing biled duct tumor2010

    • Author(s)
      Ohtsuka M, et al
    • Journal Title

      J Hepatobiliaiy Pancreat Sci

      Volume: 17 Pages: 236-240

    • NAID

      10027422468

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胆道癌発癌の病理学的および分子生物学的メカニズム2010

    • Author(s)
      大塚将之, 他
    • Journal Title

      胆と膵

      Volume: 31 Pages: 169-175

    • Related Report
      2010 Annual Research Report
  • [Presentation] 粘液産生胆管腫瘍の臨床病理学的検討と治療方針2012

    • Author(s)
      大塚将之、清水宏明、宮崎勝
    • Organizer
      第48回日本胆道学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 腫瘤形成型肝内胆管癌におけるNotch2の発現とその意義2011

    • Author(s)
      中島正之、大塚将之、木村文夫、清水宏明、吉留博之、加藤厚、古川勝規、吉富秀幸、竹内男、宮崎勝
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 胆管の腫瘍分類と展開:胆管内乳頭状腫瘍(IPNB)を中心に2011

    • Author(s)
      大塚将之、木村文夫、清水宏明、吉留博之、加藤厚、宮崎勝
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 胆管の腫瘍分類と展開:胆管内乳頭状腫瘍(IPNB)を中心に2011

    • Author(s)
      大塚将之, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-04-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝内胆管癌症例に対する積極的外科切除とGemcitabineによる術前術後化学療法の意義2010

    • Author(s)
      大塚将之, 他
    • Organizer
      第38回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 粘液産生胆管腫瘍と粘液非産生性乳頭状腫瘍は胆管内乳頭状腫瘍として一つの疾患概念にまとめられるか?2010

    • Author(s)
      大塚将之、木村文夫、清水宏明、吉留博之、加藤厚、吉富秀幸、古川勝規、竹内男、高屋敷吏、須田浩介、高野重紹、久保木知、宮崎勝
    • Organizer
      第22回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] すべての胆管内乳頭状腫瘍は膵管内乳頭粘液性腫瘍の胆管カウンターパートか?2010

    • Author(s)
      大塚将之、木村文夫、清水宏明、吉留博之、加藤厚、吉富秀幸、古川勝規、竹内男、高屋敷吏、須田浩介、高野重紹、宮崎勝
    • Organizer
      第110回日本外科学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Stage III&IV肝内胆管癌5年生存例の特徴及びそれに基づく治療戦略

    • Author(s)
      大塚将之
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] 切除後長期生存肝内胆管癌の特徴及びそれに基づく治療戦略

    • Author(s)
      大塚将之
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Related Report
      2012 Annual Research Report
  • [Presentation] 粘液産生胆管腫瘍の臨床病理学的検討と治療方針

    • Author(s)
      大塚将之
    • Organizer
      第48回日本胆道学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Book] 消化器疾患最新の治療2011-2012 胆管細胞癌(肝内胆管癌)2011

    • Author(s)
      大塚将之、宮崎勝
    • Total Pages
      3
    • Publisher
      南江堂
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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