The possibility of hepatic regenerative medicine usingadipose tissue-derived mesenchymal stem cell (ADRC)
| Project/Area Number |
22591506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MORINE Yuji 徳島大学, 病院, 助教 (60398021)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Mitsuo 徳島大学, 大学院・ヘルスバイオサイエンス 研究部, 教授 (10216070)
UTSUNOMIYA Tohru 徳島大学, 大学院・ヘルスバイオサイエンス 研究部, 准教授 (30304801)
IMURA Satoru 徳島大学, 病院, 助教 (90380021)
IKEMOTO Tetsuya 徳島大学, 大学院・ヘルスバイオサイエンス 研究部, 助教 (20398019)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肝不全 / 幹細胞 / 肝再生制御因子 / 肝切除 / 肝移植 |
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| Research Abstract |
Adipose tissue represents an abundant source of adult stem cells, termed ‘adipose-derived regenerative cells (ADRC)’, with the ability to differentiate along multiple lineage pathways. In this study, we demonstrated that ADRCs could be differentiated into hepatocyte like cells, as well as protected hepatocytes by a trophic effectand a homing effect through CXCR4 / SDF1 axis in vitro and in vivo 70% hepatectomy following ischemia reperfusion rat model.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Beneficial effects of green tea catechin on massive hepatectomy model in rats2013
Author(s)
Saito Y, Mori H, Takasu C, Komatsu M, Hanaoka J, Yamada S, Asanoma M, Ikemoto T, Imura S, Morine Y, Utsunomiya T, Shimada M
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Journal Title
Related Report
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[Journal Article] The protective effect of adipose-derived stem cells against liver injury by trophic molecules2013
Author(s)
Saito Y, Shimada M, Utsunomiya T, Ikemoto T, Yamada S, Morine Y, Imura S, Mori H, Sugimoto K, Iwahashi S, Asanoma M
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Journal Title
J Surg Res
Volume: 180(1)
Pages: 162-168
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