Investigation of the central role of hepatic stellate cells in the tissue-repairing process of the liver
| Project/Area Number |
22591510
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
IIMURO Yuji 兵庫医科大学, 医学部, 教授 (30252018)
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| Co-Investigator(Kenkyū-buntansha) |
鈴村 和大 兵庫医科大学, 医学部, 助教 (50434949)
宇山 直樹 兵庫医科大学, 医学部, 研究生(研究員) (70402873)
平野 公通 兵庫医科大学, 医学部, 講師 (90340968)
藤元 治朗 兵庫医科大学, 医学部, 教授 (90199373)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肝臓外科学 / 肝類洞内皮細胞 / 門脈血流 / 肝再生 / 肝星細胞 / 流体解析 |
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| Research Abstract |
The role of non-parenchymal hepatic cells, especially hepatic stellate cells and sinusoidal endothelial cells, in liver regeneration process was investigated focusing on the identification of mechanical stress-receptors on these cells. Meanwhile, relationship between the perioperative change in portal hemodynamics and the regional liver regeneration was analyzed in humans who underwent hepatic surgery. As a result, regional liver regeneration was not homogeneous after hepatic resection, and well correlated with preceding changes in portal flow distribution in each patient. Moreover, several mechanical stress-receptors were identified in resected human liver tissues, and existence of signal transduction pathways under the receptors was suspected by identification of some proteins.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway2012
Author(s)
Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N, Fujimoto J.
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Journal Title
Laboratory Investigation
Volume: 92(1)
Issue: 1
Pages: 57-71
DOI
Related Report
Peer Reviewed
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