Application of Auto-Fluorescence Imaging for LaparoscopicHepato-biliary-pancreatic Surgery

• Project/Area Number: 22591514
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Niigata University
• Principal Investigator: MINAGAWA Masahiro 新潟大学, 医歯学総合病院, 助教 (10464009)
• Co-Investigator(Kenkyū-buntansha): KUROSAKI Isao 新潟大学, 医歯学総合病院, 講師 (50293220)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 膵臓外科学 / 内視鏡下手術 / AFI / 自己蛍光 / 蛍光内視鏡 / 内視鏡手術

Research Abstract

We found that Auto-fluorescence Imaging (AFI) is particularly useful for detection of superficial tumors. Especially in laparoscopic surgery, this technique enabled to visualize tumors well in cirrhotic liver with rough surface without drug administration nor manipulation. In addition, it was demonstrated in an animal model that fluorescein sodium injected into hepato-biliary-pancreatic vessels could provide strong fluorescence with AFI. This indicates that AFI can help recognizing anatomical location of vessels during laparoscopic surgery.

Research Products

• [Journal Article] Navigation surgery with autofluorescence imaging for small hepatocellular carcinomas invisible to ultrasonography (2011)
  • Author(s): Minagawa M, Kurosaki I, Ogawa H, Hatakeyama K
  • Journal Title: Surgery Volume: 149(6) Pages: 848-850
  • Peer Reviewed
• [Journal Article] Navigation surgery with autofluorescence imaging for small hepatocellular carcinomas invisible to ultrasonography (2011)
  • Author(s): Minagawa M, et al.
  • Journal Title: Surgery Volume: 146(6) Issue: 6 Pages: 848-850
  • DOI: 10.1016/j.surg.2009.10.044
  • Peer Reviewed
• [Presentation] Density Fluctuation of Preoperative MDCT image predicts postoperative pancreatic fistula after pancreaticoduodenectomy (2012)
  • Author(s): Minagawa M, Kurosaki I, Takano K, Takizawa K, Morimoto Y, Nakano T
  • Organizer: IASGO
  • Place of Presentation: Bangkok
  • Year and Date: 2012-12-05
• [Presentation] 体尾部膵癌に対するRadical antegrade distal pancreatectomy (2012)
  • Author(s): 皆川昌広、黒崎功、佐藤大輔、高野可赴、森本悠太、仲野哲矢
  • Organizer: 日本肝胆膵外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-06-02
• [Presentation] Density Fluctuation of Preoperative MDCT image predicts postoperative pancreatic fistula after pancreaticoduodenectom (2012)
  • Author(s): Masahiro Minagawa
  • Organizer: IASGO
  • Place of Presentation: THAI
• [Presentation] 体尾部膵癌に対する Radical antegrade distal pancreatectomy (2012)
  • Author(s): 皆川昌広
  • Organizer: 日本肝胆膵外科学会
  • Place of Presentation: 大阪
• [Presentation] Mechanical Slow Flatteringによる術後膵液瘻軽減の試み (2011)
  • Author(s): 皆川昌広,黒崎功,高野可赴,滝沢一泰,森本悠太,畠山勝義
  • Organizer: 日本内視鏡外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-12-08
• [Presentation] Laparoscopic partial resection of pancreatic tumors using low power CUSA (2011)
  • Author(s): Minagawa M, Kurosaki I, Takano K, Hatakeyama K
  • Organizer: IASGO 2011
  • Place of Presentation: Tokyo
  • Year and Date: 2011-11-12
• [Presentation] Auto-fluorescence imaging for detecting superficial liver tumors in laparoscopic surgery (2011)
  • Author(s): Minagawa M, Kurosaki I, Kitami C, Takano K, Hatakeyama K
  • Organizer: ISW 2011
  • Place of Presentation: Yokohama
  • Year and Date: 2011-08-28
• [Presentation] Auto-fluorescence imaging for detecting superficial liver tumors in laparoscopic surgery (2011)
  • Author(s): Masahiro Minagawa
  • Organizer: ISW 2011
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-28
• [Presentation] 肝硬変患者に対する低侵襲手術しての鏡視下肝切除術 (2010)
  • Author(s): 皆川昌広
  • Organizer: 日本内視鏡外科学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-12-06
• [Presentation] 肝硬変患者に対する低侵襲手術としての鏡視下肝切除 (2010)
  • Author(s): 皆川昌広,黒崎功,北見智恵,高野可赴,佐藤大輔,滝沢一泰,畠山勝義
  • Organizer: 日本内視鏡外科学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-19
• [Presentation] 膵実質CT値計測による膵液瘻リスク予測とその組織的背景の関係 (2010)
  • Author(s): 皆川昌広,黒崎功,北見智恵,黒崎亮,高野可赴,佐藤大輔,畠山勝義
  • Organizer: 日本消化器外科学会総会
  • Place of Presentation: 山口
  • Year and Date: 2010-07-14