Correlation between expression of exocrine progenitor genes and cancer stem cells in pancreatic cancer.

• Project/Area Number: 22591519
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka University
• Principal Investigator: WADA Hiroshi 大阪大学, 大学院・医学系研究科, 助教 (00572554)
• Co-Investigator(Kenkyū-buntansha): NAGANO Hiroaki 大阪大学, 大学院・医学系研究科, 准教授 (10294050) ; EGUCHI Hidetoshi 大阪大学, 大学院・医学系研究科, 助教 (90542118) ; TAKIUCHI Daisuke 大阪大学, 大学院・医学系研究科, 医員 (30571351) ; YAMADA Daisaku 大阪大学, 大学院・医学系研究科, 医員 (60571396)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 膵臓外科学 / 膵癌 / 癌幹細胞 / 膵内分泌腫瘍 / progenitor gene / 転写因子 / Progenitor gene / Pdx1 / proeniter gene

Research Abstract

We evaluated the expression of exocrine progenitor genes and cancerstem cells markers in pancreatic cancer. CD44-positive cells were enriched after preoperative chemo-radiation therapy (CRT). Pdx1 positive tumors tended to limit to pancreas after CRT. There was no correlation between expression of Pdx1 and CD44. CD44-positive tumors without expression of Pdx1 were poor prognosis. These results suggested that transfection of exocrine progenitor genes may decrease its malignant behavior in pancreatic cancer.

Research Products

• [Journal Article] Preoperative Chemoradiotherapy, Surgery and Adjuvant Therapy for Resectable Pancreatic Cancer (2013)
  • Author(s): Eguchi H, Nagano H, Tanemura M, Takeda Y, Marubashi S, Kobayashi S, Kawamoto K, Wada H, Hama N, Akita H, Mori M, Doki Y.
  • Journal Title: Hepatogastroenterology. Volume: 60 Pages: 126-126
• [Journal Article] Arterial stimulation and venous sampling for glucagonomas of the pancreas (2012)
  • Author(s): Eguchi H, Tanemura M, Marubashi S, Kobayashi S, Wada H, Okita K, Iwahashi H, Imagawa A, Shimomura I, Osuga K, Umeshita K, Wakasa K, Mori M, Doki Y, Nagano H
  • Journal Title: Hepatogastroenterology. Volume: 59 Pages: 276-9
• [Journal Article] A case report of total remnant pancreatectomy for ductal carcinoma after distal pancreatectomy for invasive intraductal papillary mucinous carcinoma (2012)
  • Author(s): Okubo K, Hama N, Kobayashi S, Eguchi H, Akita H, Wada H, Kawamoto K, Marubashi S, Tanemura M, Umeshita K, Mori M, Doki Y, Nagano H
  • Journal Title: Gan To Kagaku Ryoho Volume: 39 Pages: 2140-2
• [Journal Article] Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity (2011)
  • Author(s): Akita H, Nagano H, Takeda Y, Eguchi H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Takahashi H, Ohigashi H, Tomita Y, Ishikawa O, Mori M, Doki Y
  • Journal Title: Oncogene. Volume: 30 Pages: 3468-76
• [Journal Article] Synergistic antitumor effect of interferon-β with gemcitabine in interferon-α-non-responsive pancreatic cancer cells (2011)
  • Author(s): Tomimaru Y, Eguchi H, Wada H, Tomokuni A, Kobayashi S, Marubashi S, Takeda Y, Tanemura M, Umeshita K, Mori M, Doki Y, Nagano H
  • Journal Title: Int J Oncol. Volume: 38 Pages: 1237-43
• [Journal Article] A case report of port-site metastasis of pancreatic cancer after laparoscope assistted distalpancreatectomy (2011)
  • Author(s): Koga C, Tanemura M, Wada H, Kobayashi S, Marubashi S, Eguchi H, Mori M, Doki Y, Nagano H
  • Journal Title: Gan To Kagaku Ryoho Volume: 38 Pages: 2454-6
• [Journal Article] 腫瘍をめぐる Q&A(Question 53) c-MET と膵癌癌幹細胞(Q&A)
  • Author(s): 向井 亮太, 秋田 裕史, 江口 英利, 永野 浩昭, 土岐 祐一郎, 森 正樹
  • Journal Title: Surgery Frontier Volume: 20 Pages: 94-96
• [Presentation] 膵癌細胞株におけるgemcitabine耐性とmicroRNA-181b との検討 (2011)
  • Author(s): 瀧内 大輔, 江口 英利, 和田 浩志, 川本 弘一, 小林 省吾, 丸橋 繁, 種村 匡弘, 永野 浩昭, 森 正樹, 土岐 祐一郎
  • Organizer: 第70回日本癌学会総会