Pancreatic cancer immunotherapy using tumor lysate vaccine, engineered to express α-gal epitopes, can target pancreatic cancer stem cells

• Project/Area Number: 22591520
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: 国立病院機構呉医療センター (2012); Department of Clinical Research, National Hospital Organization Kure Medical Center (2011); Osaka University (2010)
• Principal Investigator: TANRMURA Masahiro 国立病院機構呉医療センター, 中国がんセンター, 外科医長 (30379250)
• Co-Investigator(Kenkyū-buntansha): DOKI Yuichirou 大阪大学, 医学系研究科, 教授 (20291445) ; MIYOSHI Eiji 大阪大学, 医学系研究科, 教授 (20322183)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 膵癌 / 免疫療法 / 癌幹細胞 / 糖鎖 / 創薬 / 癌肝細胞

Research Abstract

The results of our in vitro and in vivo experiments emphasize the efficiency of tumor lysate vaccines expressing α-gal epitopes in targeting all pancreatic cancer cells, including differentiated cancer cells and pancreatic CSCs. Vaccination with α-gal tumor lysate induced strong long-lasting anti-tumor immunity. The α-gal tumor lysate vaccine may form the basis for testing this novel therapeutic approach in human clinical trials.

Research Products

• [Journal Article] Hepatectomy based on the tumor hemodynamics for hepatocellular carcinoma: a comparison among the hybrid and pure laparoscopic procedures and open surgery. (2013)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Kawamoto K, Wada H, Eguchi H, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: SurgEndosc Volume: 27 (2) Pages: 610-7
• [Journal Article] Significant Improvement in Islet Yield and Survival with Modified ET-Kyoto Solution (ET-Kyoto/Neutrophil Elastase Inhibitor). (2013)
  • Author(s): Machida T, Tanemura M, Ohmura Y, Tanida T, Wada H, Kobayashi S, Marubashi S, H Eguchi , Ito T, Nagano H, Mori M, Doki Y, Sawa Y
  • Journal Title: Cell Transplant Volume: 22 (1) Pages: 159-73
• [Journal Article] Role of α-gal epitope/anti-Gal antibody reaction in immunotherapy and its clinicalapplication in pancreatic cancer. (2013)
  • Author(s): Tanemura M, Miyoshi, Nagano H, Eguchi H,Taniyama K, Kamiike W, Mori M, Doki Y
  • Journal Title: Cancer Science Volume: 104 (3) Pages: 282-90
• [Journal Article] Clinicopathological features of long-term survivors for advanced biliary tract cancer and impact of the number of lymph nodes involved. (2013)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Kawamoto K, Wada H, Eguchi H, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: Int J Surg. Volume: 11 (2) Pages: 145-51
• [Journal Article] IntragraftTranscriptome Level of CXCL9 as Biomarker of Acute Cellular Rejection after Liver Transplantation. (2012)
  • Author(s): AsaokaT, Marubashi S, Kobayashi S, Hama N, Eguchi H, Takeda Y, Tanemura M, Wada H, Takemasa I, Takahashi H, Ruiz P, Doki Y, Mori M, Nagano H
  • Journal Title: J SurgRes Volume: (Epub ahead of print)
• [Journal Article] Arterial Stimulation and Venous Sampling for Glucagonomas of the Pancreas. (2012)
  • Author(s): Eguchi H, Tanemura M, Marubashi S, Kobayashi S, Wada H, Okita K, Iwahashi H, Imagawa A, Shimomura I, Osuga K, Umeshita K, Wakasa K, Mori M, Doki Y, Nagano H
  • Journal Title: Hepatogastroenterology Volume: 59(113) Pages: 276-9
• [Journal Article] Significance of Alanine Aminopeptidase N (APN) in Bile in the Diagnosis of Acute Cellular Rejection After Liver Transplantation. (2012)
  • Author(s): Kim C, Aono S, Marubashi S, Wada H, Kobayashi S, Eguchi H, Takeda Y, Tanemura M,Okumura N, Takao T, Doki Y, Mori M, Nagano H
  • Journal Title: J Surg Res Volume: 175(1) Pages: 138-48
• [Journal Article] Role of Rapamycin induced autophagy in pancreatic islets. (2012)
  • Author(s): Tanemura M, Nagano H, Taniyama K, Kamiike W, Mori M, Doki Y
  • Journal Title: Am J Transplant Volume: 12(4) Pages: 1067-1067
• [Journal Article] Equivalent outcomes after anatomical and non-anatomical resection of smallsolitary hepatocellular carcinoma in patients with preserved liver function. (2012)
  • Author(s): Tomimaru Y, Eguchi H, Marubashi S, WadaH, Kobayashi S, Tanemura M, Umeshita K, Doki Y, Mori M,Nagano H
  • Journal Title: Digest Dis Sci Volume: 57(7) Pages: 1942-8
• [Journal Article] PLOD2 induced under hypoxia is a novel prognostic factor for hepatocellular carcinoma after curative resection. (2012)
  • Author(s): Noda T, Yamamoto H, Takemasa I, Yamada D, Uemura M, Wada H, Kobayashi S, Marubashi S, Eguchi H, Tanemura M, Umeshita K, Doki Y, Mori M, Nagano H
  • Journal Title: Liver Int. Volume: 32 (1) Pages: 110-8
• [Journal Article] Xenon-Inhalation Computed Tomography for Noninvasive Quantitative Measurement of Tissue Blood Flow in Pancreatic Tumor. (2012)
  • Author(s): Kubota M, Murakami T, Nagano H, Eguchi H, Marubashi S, Kobayashi S, Wada H, Tanemura M, Dono K, Nakamori S, Sakon M, Monden M, Mori M, Doki Y
  • Journal Title: Dig Dis Sci. Volume: 57(3) Pages: 801-5
• [Journal Article] Rapamycin causes upregulation of autophagy and impairs islets function both in vitro and in vivo. (2012)
  • Author(s): Tanemura M, Ohmura Y, Deguchi T, Machida T, Tsukamoto R, Wada H, Kobayashi S, Marubashi S, Eguchi H, Ito T, Nagano H, Mori M, Doki Y
  • Journal Title: Am J Transplant. Volume: 12(1) Pages: 102-14
• [Journal Article] Fibrin Sealant with PGA felt for Prevention of Bile Leakage after Liver Resection (2012)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Wada H, Eguchi H, Takeda Y,Tanemura M, And YD
  • Journal Title: Hepatogastroenterology. Volume: 59 (120) Pages: 2564-8
• [Journal Article] IntragraftTranscriptome Level of CXCL9 as Biomarker of Acute Cellular Rejection after Liver Transplantation. (2012)
  • Author(s): AsaokaT, Marubashi S, Kobayashi S, Hama N, Eguchi H, Takeda Y, Tanemura M, Wada H, Takemasa I, Takahashi H, Ruiz P, Doki Y, Mori M, Nagano H.
  • Journal Title: J SurgRes Volume: Jul 26
  • Peer Reviewed
• [Journal Article] Hepatectomy based on the tumor hemodynamics for hepatocellular carcinoma: a comparison among the hybrid and pure laparoscopic procedures and open surgery. (2012)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Kawamoto K, Wada H, Eguchi H, Tanemura M, Umeshita K, Doki Y, Mori M.
  • Journal Title: SurgEndosc Volume: Aug 31
  • Peer Reviewed
• [Journal Article] Arterial Stimulation and Venous Sampling for Glucagonomas of the Pancreas (2012)
  • Author(s): Eguchi H, Tanemura M, Marubashi S, Kobayashi S, Wada H, Okita K, Iwahashi H, Imagawa A, Shimomura I, Osuga K, Umeshita K, Wakasa K, Mori M, Doki Y, Nagano H.
  • Journal Title: Hepatogastroenterology Volume: 59(113) Pages: 276-9
  • Peer Reviewed
• [Journal Article] Significance of Alanine Aminopeptidase N (APN) in Bile in the Diagnosis of Acute Cellular Rejection After Liver Transplantation (2012)
  • Author(s): Kim C, Aono S, Marubashi S, Wada H, Kobayashi S, Eguchi H, Takeda Y, Tanemura M,Okumura N, Takao T, Doki Y, Mori M, Nagano H
  • Journal Title: J Surg Res Volume: 175(1) Pages: 138-48
  • Peer Reviewed
• [Journal Article] Role ofRapamycin induced autophagy in pancreatic islets (2012)
  • Author(s): Tanemura M, Nagano H, Taniyama K, Kamiike W, Mori M, Doki Y
  • Journal Title: Am J Transplant Volume: 2012Apr;12(4) Pages: 1067-1067
  • Peer Reviewed
• [Journal Article] Significant Improvement in Islet Yield and Survival with Modified ET-Kyoto Solution (ET-Kyoto/Neutrophil Elastase Inhibitor) (2012)
  • Author(s): Machida T, Tanemura M, Ohmura Y, Tanida T, Wada H, Kobayashi S, Marubashi S, H Eguchi , Ito T, Nagano H, Mori M, Doki Y, Sawa Y
  • Journal Title: Cell Transplant Volume: Apr 2
  • Peer Reviewed
• [Journal Article] Equivalent outcomes after anatomical and non-anatomical resection of smallsolitary hepatocellular carcinoma in patients with preserved liver function (2012)
  • Author(s): Tomimaru Y, Eguchi H, Marubashi S, WadaH, Kobayashi S, Tanemura M, Umeshita K, Doki Y, Mori M,Nagano H
  • Journal Title: Digest Dis Sci Volume: 57(7) Pages: 1942-8
  • Peer Reviewed
• [Journal Article] PLOD2 induced under hypoxia is a novel prognostic factor for hepatocellular carcinoma after curative resection (2012)
  • Author(s): Noda T, Yamamoto H, Takemasa I, Yamada D, Uemura M, Wada H, Kobayashi S, Marubashi S, Eguchi H, Tanemura M, Umeshita K, Doki Y, Mori M, Nagano H
  • Journal Title: Liver Int Volume: 32 (1) Pages: 110-8
  • Peer Reviewed
• [Journal Article] Xenon-Inhalation Computed Tomography for Noninvasive Quantitative Measurement of Tissue Blood Flow in Pancreatic Tumor (2012)
  • Author(s): Kubota M, Murakami T, Nagano H, Eguchi H, Marubashi S, Kobayashi S, Wada H, Tanemura M, Dono K, Nakamori S, Sakon M, Monden M, Mori M, Doki Y
  • Journal Title: Dig Dis Sci Volume: 57(3) Pages: 801-5
  • Peer Reviewed
• [Journal Article] Diagnostic value of FDG-PET for lymp node metastasis and outcome ofsurgery for biliary cancer (2011)
  • Author(s): Kobayashi S, Nagano H, Hoshino H, Wada H, Marubashi S, Eguchi H,Takeda Y, Tanemura M, Kim T, Shimosegawa E, Hatazawa J, Doki Y, Mori M
  • Journal Title: J SurgOncol Volume: 103(3) Pages: 223-9
• [Journal Article] Prognosis of hepatocellular carcinoma with biliary tumor thrombi following liver surgery (2011)
  • Author(s): Noda T, Nagano H, Tomimaru Y, Murakami M, Wada H, Kobayashi S, Marubashi S, Eguchi H, Takeda Y, Tanemura M, Umeshita K, Kim T, Wakasa K, Doki Y, Mori M
  • Journal Title: Surgery Volume: 49(3) Pages: 371-7
• [Journal Article] Tyrosine kinase inhibitor PTK/ZK enhances the anti-tumor effects of interferon-α/5-fluorouracil therapy for hepatocellularcarcinoma cells. (2011)
  • Author(s): Murakami M, Kobayashi S, Marubashi S, Tomimaru Y, Noda T, Wada H,Eguchi H, Takeda Y, Tanemura M, Umeshita K, Doki Y, Mori M, HiroakiNagano H
  • Journal Title: Ann SurgOncol Volume: 18(2) Pages: 589-96
• [Journal Article] A thick pancreas is a risk factor for pancreatic fistula after a distal pancreatectomy:Selection of the closure technique according to the thickness. (2011)
  • Author(s): Eguchi H, Nagano H, Tanemura M, Takeda Y, Marubashi S, Kobayashi S, Wada H, Umeshita K, Mori M, Doki Y
  • Journal Title: Dig Surg Volume: 28(1) Pages: 50-6
• [Journal Article] Clinical Significance of Alpha-Fetoprotein mRNA in Peripheral Blood in Liver Resection for Hepatocellular Carcinoma (2011)
  • Author(s): Marubashi S, Nagano H, Wada H, Kobayashi S, Eguchi H, Takeda Y, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: Ann SurgOncol Volume: 18 (8) Pages: 2200-9
• [Journal Article] IGFBP7 downregulation is associated with tumor progression and clinical outcome in hepatocellular carcinoma. (2011)
  • Author(s): Tomimaru Y, Eguchi H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Umeshita K, Kim T, Wakasa K, Doki Y, Mori M, Nagano H
  • Journal Title: Int J Cancer Volume: 15;130(2) Pages: 319-27
• [Journal Article] Donor Hepatectomy for Living Donor Liver Transplantation: Learning Steps and Surgical Outcome. (2011)
  • Author(s): Marubashi S, Nagano H, Wada H, Kobayashi S, Eguchi H, Takeda Y,Tanemura M, Doki Y, Mori M.
  • Journal Title: Dig Dis Sci Volume: 56 (8) Pages: 2482-90
• [Journal Article] Synergistic antitumor effect of interferon-β with gemcitabine in interferon-α-non-responsive pancreatic cancer cells. (2011)
  • Author(s): Tomimaru Y, Eguchi H, Wada H, Tomokuni A, Kobayashi S, Marubashi S, Takeda Y, Tanemura M, Umeshita K, Mori M, Doki Y, Nagano H
  • Journal Title: Int J Oncol Volume: 38(5) Pages: 1237-43
• [Journal Article] Mural nodule in branch duct-type intraductal papillary mucinous neoplasms of the pancreas is a marker of malignant transformation and indication for surgery. (2011)
  • Author(s): Akita H, Takeda Y, Hoshino H, Wada H, Kobayashi S, Marubashi S, Eguchi H, Tanemura M, Mori M, Doki Y, Nagano H
  • Journal Title: Am J Surg Volume: 202 (2) Pages: 214-9
• [Journal Article] Combination use of anti-CD133 antibody and SSA lectin can effectively enrich cells with high tumorigenicity. (2011)
  • Author(s): Moriwaki K, Okudo K, Haraguchi N, Takeishi S, Sawaki H, Narimatsu H, Tanemura M, Ishii H, Mori M, Miyoshi E
  • Journal Title: Cancer Sci Volume: 102 (6) Pages: 1164-70
  • NAID: 10029294388
• [Journal Article] Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity. (2011)
  • Author(s): Akita H, Nagano H, Takeda Y, Eguchi H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Takahashi H, Ohigashi H, Tomita Y, Ishikawa O, Mori M, Doki Y
  • Journal Title: Oncogene Volume: 4; 30 (31) Pages: 3468-76
• [Journal Article] Successful pregnancy after simultaneous pancreas-kidney transplantation from a brain-dead donor: the first case report in Japan. (2011)
  • Author(s): Koyama S, Tomimatsu T, Kanagawa T, Daimon E, Kimura T, Kuroda A,Tanemura M, Doki Y, Ito T
  • Journal Title: J Obstetrics Gynaecol Res Volume: 37 (11) Pages: 1711-6
• [Journal Article] Long-term outcome of combined subcutaneous interferon-αand intra-arterial 5-fluorouracil treatment for advanced hepatocellular carcinoma with major portal vein thrombosis. (2011)
  • Author(s): Nagano H, Wada H, Kobayashi S, Marubashi S, Eguchi H, Tanemura M, Tomimaru Y, Osuga K, Umeshita K, Doki Y, Mori M
  • Journal Title: Oncology Volume: 80 (1-2) Pages: 63-9
• [Journal Article] Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. (2011)
  • Author(s): Tomimaru Y, Eguchi H, Nagano H, Wada H, Kobayashi S, Marubashi S,Tanemura M, Tomokuni A, Takemasa I, Umeshita K, Kanto T, Doki Y, Mori M
  • Journal Title: J Hepatol Volume: 56 (1) Pages: 167-75
• [Journal Article] Significance of Alanine Aminopeptidase N (APN) in Bile in the Diagnosis of Acute Cellular Rejection After Liver Transplantation. (2011)
  • Author(s): Kim C, Aono S, Marubashi S, Wada H, Kobayashi S, Eguchi H, Takeda Y, Tanemura M, Okumura N, Takao T, Doki Y, Mori M, Nagano H
  • Journal Title: J Surg Res Volume: (Epub ahead of print)
• [Journal Article] Treatment of borderline cases for curative resection of biliary tract cancer. (2011)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Wada H, Eguchi H, Takeda Y, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: J SurgOncol Volume: 104 (5) Pages: 499-503
• [Journal Article] Reprogramming of mouse and human cells to pluripotency using mature microRNAs. (2011)
  • Author(s): Miyoshi N, Ishii H, Tanemura M, Sekimoto M, Doki Y, Mori M
  • Journal Title: Cell Stem Cell Volume: 3; 8 (6) Pages: 633-8
• [Journal Article] Experience with the use of fibrin sealant plus polyglycolic acid felt at the cut surface of the liverinlaparoscopic hepatectomy. (2011)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Wada H, Takeda Y, Eguchi H, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: SurgEndosc Volume: 25 (11) Pages: 3590-6
• [Journal Article] Successful adult ABO incompatible living donor liver transplantation: experience with double infusion through the hepatic artery and portal vein. (2011)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Wada H, Takeda Y, Eguchi H, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: Hepatogastroenterology Volume: 58(106) Pages: 503-7
• [Journal Article] Role of the Hypoxia-Related Gene, JMJD1A, in Hepatocellular Carcinoma: Clinical Impact on Recurrence after Hepatic Resection. (2011)
  • Author(s): Yamada D, Kobayashi S, Yamamoto H, Tomimaru Y, Noda T, Uemura M, Wada H, Marubashi S, Eguchi H,Tanemura M, Doki Y, Mori M, Nagano H
  • Journal Title: Ann SurgOncol Volume: (Epub ahead of print)
• [Journal Article] Diagnostic value of FDG-PET for lymph node metastasis and outcome of surgery for biliary cancer (2011)
  • Author(s): Kobayashi S, Nagano H, Hoshino H, Wada H, Marubashi S, Eguchi H, Takeda Y, Tanemura M, Kim T, Shimosegawa E, Hatazawa J, Doki Y, Mori M
  • Journal Title: J Surg Oncol Volume: 103(3) Pages: 223-9
  • Peer Reviewed
• [Journal Article] Tyrosine kinase inhibitor PTK/ZK enhances the anti-tumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells (2011)
  • Author(s): Murakami M, Kobayashi S, Marubashi S, Tomimaru Y, Noda T, Wada H, Eguchi H, Takeda Y, Tanemura M, Umeshita K, Doki Y, Mori M, Hiroaki Nagano H
  • Journal Title: Ann Surg Oncol Volume: 18(2) Pages: 589-96
  • Peer Reviewed
• [Journal Article] A thick pancreas is a risk factor for pancreatic fistula after a distal pancreatectomy : Selection of the closure technique according to the thickness (2011)
  • Author(s): Eguchi H, Nagano H, Tanemura M, Takeda Y, Marubashi S, Kobayashi S, Wada H, Umeshita K, Mori M, Doki Y
  • Journal Title: Dig Surg Volume: 28(1) Pages: 50-6
  • Peer Reviewed
• [Journal Article] Clinical Significance of Alpha-Fetoprotein mRNA in Peripheral Blood in Liver Resection for Hepatocellular Carcinoma (2011)
  • Author(s): Marubashi S, Nagano H, Wada H, Kobayashi S, Eguchi H, Takeda Y, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: Ann Surg Oncol Volume: 18(8) Pages: 2200-9
  • Peer Reviewed
• [Journal Article] IGFBP7 downregulation is associated with tumor progression and clinical outcome in hepatocellular carcinoma (2011)
  • Author(s): Tomimaru Y, Eguchi H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Umeshita K, Kim T, Wakasa K, Doki Y, Mori M, Nagano H
  • Journal Title: Int J Cancer Volume: 15;130(2) Pages: 319-27
  • Peer Reviewed
• [Journal Article] Donor Hepatectomy for Living Donor Liver Transplantation : Learning Steps and Surgical Outcome (2011)
  • Author(s): Marubashi S, Nagano H, Wada H, Kobayashi S, Eguchi H, Takeda Y, Tanemura M, Doki Y, Mori M
  • Journal Title: Dig Dis Sci Volume: 56(8) Pages: 2482-90
  • Peer Reviewed
• [Journal Article] Synergistic antitumor effect of interferon-ss with gemcitabine in interferon-α-non-responsive pancreatic cancer cells (2011)
  • Author(s): Tomimaru Y, Eguchi H, Wada H, Tomokuni A, Kobayashi S, Marubashi S, Takeda Y, Tanemura M, Umeshita K, Mori M, Doki Y, Nagano H
  • Journal Title: Int J Oncol Volume: 38(5) Pages: 1237-43
  • Peer Reviewed
• [Journal Article] Mural nodule in branch duct-type intraductal papillary mucinous neoplasms of the pancreas is a marker of malignant transformation and indication for surgery (2011)
  • Author(s): Akita H, Takeda Y, Hoshino H, Wada H, Kobayashi S, Marubashi S, Eguchi H, Tanemura M, Mori M, Doki Y, Nagano H
  • Journal Title: Am J Surg Volume: 202(2) Pages: 214-9
  • Peer Reviewed
• [Journal Article] Combination use of anti-CD133 antibody and SSA lectin can effectively enrich cells with high tumorigenicity (2011)
  • Author(s): Moriwaki K, Okudo K, Haraguchi N, Takeishi S, Sawaki H, Narimatsu H, Tanemura M, Ishii H, Mori M, Miyoshi E
  • Journal Title: Cancer Sci Volume: 102(6) Pages: 1164-70
  • NAID: 10029294388
  • Peer Reviewed
• [Journal Article] Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity (2011)
  • Author(s): Akita H, Nagano H, Takeda Y, Eguchi H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Takahashi H, Ohigashi H, Tomita Y, Ishikawa O, Mori M, Doki Y
  • Journal Title: Oncogene Volume: 4;30(31) Pages: 3468-76
  • Peer Reviewed
• [Journal Article] Successful pregnancy after simultaneous pancreas-kidney transplantation from a brain-dead donor : the first case report in Japan (2011)
  • Author(s): Koyama S, Tomimatsu T, Kanagawa T, Daimon E, Kimura T, Kuroda A, Tanemura M, Doki Y, Ito T
  • Journal Title: J Obstetrics Gynaecol Res Volume: 37(11) Pages: 1711-6
  • Peer Reviewed
• [Journal Article] Long-term outcome of combined subcutaneous interferon-α and intra-arterial 5-fluorouracil treatment for advanced hepatocellular carcinoma with major portal vein thrombosis (2011)
  • Author(s): Nagano H, Wada H, Kobayashi S, Marubashi S, Eguchi H, Tanemura M, Tomimaru Y, Osuga K, Umeshita K, Doki Y, Mori M
  • Journal Title: Oncology Volume: 80(1-2) Pages: 63-9
  • Peer Reviewed
• [Journal Article] Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma (2011)
  • Author(s): Tomimaru Y, Eguchi H, Nagano H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Tomokuni A, Takemasa I, Umeshita K, Kanto T, Doki Y, Mori M
  • Journal Title: J Hepatol Volume: 56(1) Pages: 167-75
  • Peer Reviewed
• [Journal Article] Significance of Alanine Aminopeptidase N (APN) in Bile in the Diagnosis of Acute Cellular Rejection After Liver Transplantation (2011)
  • Author(s): Kim C, Aono S, Marubashi S, Wada H, Kobayashi S, Eguchi H, Takeda Y, Tanemura M, Okumura N, Takao T, Doki Y, Mori M, Nagano H
  • Journal Title: J Surg Res Volume: Mar 25(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Treatment of borderline cases for curative resection of biliary tract cancer (2011)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Wada H, Eguchi H, Takeda Y, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: J Surg Oncol Volume: 104(5) Pages: 499-503
  • Peer Reviewed
• [Journal Article] Reprogramming of mouse and human cells to pluripotency using mature microRNAs (2011)
  • Author(s): Miyoshi N, Ishii H, Tanemura M, Sekimoto M, Doki Y, Mori M
  • Journal Title: Cell Stem Cell Volume: 3;8(6) Pages: 633-8
  • Peer Reviewed
• [Journal Article] Experience with the use of fibrin sealant plus polyglycolic acid felt at the cut surface of the liver in laparoscopic hepatectomy (2011)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Wada H, Takeda Y, Eguchi H, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: Surg Endosc Volume: 25(11) Pages: 3590-6
  • Peer Reviewed
• [Journal Article] Successful adult ABO incompatible living donor liver transplantation : experience with double infusion through the hepatic artery and portal vein (2011)
  • Author(s): Kobayashi S, Nagano H, Marubashi S, Wada H, Takeda Y, Eguchi H, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: Hepatogastroenterology Volume: 58(106) Pages: 503-7
  • Peer Reviewed
• [Journal Article] Role of the Hypoxia-Related Gene, JMJD1A, in Hepatocellular Carcinoma : Clinical Impact on Recurrence after Hepatic Resection (2011)
  • Author(s): Yamada D, Kobayashi S, Yamamoto H, Tomimaru Y, Noda T, Uemura M, Wada H, Marubashi S, Eguchi H, Tanemura M, Doki Y, Mori M, Nagano H
  • Journal Title: Ann Surg Oncol Volume: May 24(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Increased immunogenicity of tumor-associated antigen, MUC1, engineered to express α-gal epitopes: A novel approach to immunotherapy in pancreatic cancer (2010)
  • Author(s): Deguchi T, Tanemura M, Miyoshi E, Nagano H, Machida T, Ohmura Y, Kobayashi S, Marubashi S, Eguchi H, Takeda Y, Ito T, Mori M, Doki Y and Sawa Y
  • Journal Title: Cancer Research Volume: 70 (13) Pages: 5259-69
• [Journal Article] Effects of preceding interferon therapy on outcome after surgery for hepatitis C virus-related hepatocellular carcinoma (2010)
  • Author(s): Tomimaru Y, Nagano H, Eguchi H, Kobayashi S, Marubashi S, Wada H, Tanemura M, Umeshita K, Hiramatsu N, Takehara T, Doki Y, Mori M
  • Journal Title: J of Surg Oncol Volume: 15;102(4) Pages: 308-14
• [Journal Article] MicroRNA-21 induces resistance to the anti-tumour effect of interferon-α/5-fluorouracil in hepatocellular carcinoma cells (2010)
  • Author(s): Tomimaru Y, Eguchi H, Nagano H, Wada H, Tomokuni A, Kobayashi S, Marubashi S, Takeda Y, Tanemura M, Umeshita K, Doki Y, Mori M
  • Journal Title: Br J Cancer Volume: 9;103(10) Pages: 1617-26
• [Journal Article] Combined Transplantation of Pancreatic Islets and Adipose Tissue-Derived Stem Cells Enhances the Survival and Insulin Function ofIslet Grafts in Diabetic Mice (2010)
  • Author(s): Ohmura Y, Tanemura M, Kawaguchi N, Machida T, Tanida T, Deguchi T, Wada H, Kobayashi S, Marubashi S, Eguchi H, Takeda Y, Matsuura N, Ito T, Nagano H, Doki Y and Mori M
  • Journal Title: Transplantation Volume: 27;90(12) Pages: 1366-73
• [Journal Article] Increased immunogenicity of tumor-associated antigen, MUC1, engineered to express α-gal epitopes : A novel approach to immunotherapy in pancreatic cancer. (2010)
  • Author(s): Deguchi T, Tanemura M, Miyoshi E, Nagano H, Machida T, Ohmura Y, Kobayashi S, Marubashi S, Eguchi H, Takeda Y, Ito T, Mori M, Doki Y, Sawa Y.
  • Journal Title: Cancer Research Volume: 70(13) Pages: 5259-69
  • Peer Reviewed
• [Journal Article] Effects of preceding interferon therapy on outcome after surgery for hepatitis C virus-related hepatocellular carcinoma. (2010)
  • Author(s): Tomimaru Y, Nagano H, Eguchi H, Kobayashi S, Marubashi S, Wada H, Tanemura M, Umeshita K, Hiramatsu N, Takehara T, Doki Y, Mori M
  • Journal Title: J of Surg Oncol Volume: 15;102(4) Pages: 308-14
  • Peer Reviewed
• [Journal Article] MicroRNA-21 induces resistance to the anti-tumour effect of interferon-α/5-fluorouracil in hepatocellular carcinoma cells. (2010)
  • Author(s): Tomimaru Y, Eguchi H, Nagano H, Wada H, Tomokuni A, Kobayashi S, Marubashi S, Takeda Y, Tanemura M, Umeshita K, Doki Y, Mori M.
  • Journal Title: Br J Cancer Volume: 9;103(10) Pages: 1617-26
  • Peer Reviewed
• [Presentation] A new immunotherapy for pancreatic cancer stem cells by tumor lysate vaccine, expressing α-gal epitopes (2012)
  • Author(s): Masahiro Tanemura
  • Organizer: AACR総会
  • Place of Presentation: シカゴ
• [Presentation] Immune-based therapy with tumor lysate, remodeled to express α-gal epitopes induce significant B and T cell responses against pancreatic cancer. (2012)
  • Author(s): Masahiro Tanemura
  • Organizer: AACR総会
  • Place of Presentation: シカゴ
• [Presentation] A novel immunotherapy for pancreatic cancer stem cells by tumor lysate vaccine, expressing α-gal epitopes (2012)
  • Author(s): Masahiro Tanemura
  • Organizer: Pancreas Cancer 2012 in Kyoto
  • Place of Presentation: 京都
• [Presentation] 糖鎖改変ワクチンを用いた膵癌術後成績向上をめざした挑戦 (2012)
  • Author(s): 種村匡弘
  • Organizer: 日本臨床外科学会総会
  • Place of Presentation: 東京、新宿
• [Presentation] 脂肪組織由来幹細胞(ADSC)の臨床応用への展開 -自己ADSCを用いた革新的移植医療の実現に向けて- (2012)
  • Author(s): 種村匡弘
  • Organizer: 米子再生医学セミナー
  • Place of Presentation: 鳥取大学医学部附属病院
  • Invited
• [Presentation] 遠隔成績からみた1型糖尿病に対する脳死膵臓移植の現状と再生医療を応用した次世代型糖尿病根治療法の研究・開発 (2012)
  • Author(s): 種村匡弘
  • Organizer: 香川大学移植セミナー
  • Place of Presentation: 香川大学医学部附属病院
  • Invited
• [Presentation] A new immunotherapy for pancreatic cancer stem cells by tumor lysate vaccine, expressing -gal epitopes (2012)
  • Author(s): Masahiro Tanemura
  • Organizer: AACR総会
  • Place of Presentation: シカゴ
• [Presentation] Immune -based therapy with tumor lysate, remodeled to express α-gal epitopes induce significant B and T cell responses against pancreatic cancer. (2012)
  • Author(s): Masahiro Tanemura
  • Organizer: AACR総会
  • Place of Presentation: シカゴ
• [Presentation] 遠隔成績からみた1型糖尿病に対する脳死膵臓移植の現状と再生医療を応用した次世代型糖尿病根治療法の開発 (2011)
  • Author(s): 種村匡弘
  • Organizer: 第14回阪神肝胆膵疾患研究会
  • Place of Presentation: 甲子園ノボテル
  • Year and Date: 2011-12-02
• [Presentation] 遠隔成績からみた1型糖尿病に対する脳死膵臓移植の現状と明日の糖尿病再生医療を構築する基礎研究 (2011)
  • Author(s): 種村匡弘
  • Organizer: 第253回呉消化器病研究会
  • Place of Presentation: 呉阪急ホテル
  • Year and Date: 2011-10-15
• [Presentation] ブタ型糖鎖(α-galエピトープ)への改変による新しい膵がんワクチン療法の開発と臨床応用 (2011)
  • Author(s): 種村匡弘
  • Organizer: 関西グライコサイエンス
  • Place of Presentation: 大阪大学
  • Year and Date: 2011-05-14
• [Presentation] Vaccination with pancreatic cancer cells expressing α-gal epitopes effectively induced immuneresponses against not only differentiated cancer cells but also cancer stem cells (2011)
  • Author(s): Masahiro Tanemura
  • Organizer: AACR総会
  • Place of Presentation: フロリダ
• [Presentation] Preliminary experiment of α-gal epitopes immune-based therapy against pancreatic cancer, by tumor cell lysates (2011)
  • Author(s): Masahiro Tanemura
  • Organizer: AACR総会
  • Place of Presentation: フロリダ
• [Presentation] MUC1, remodeled to express α-gal epitopes immune-based therapy can elicit both significant prolonged survival and effective antibody production against multiple tumor-associated antigens (2010)
  • Author(s): Tanemura M, Deguchi T, Miyoshi E, Nagano H, Ohmura Y, Machida T, Wada H, Kobayashi S, Marubash S, Eguchi H, Takeda Y, Ito T, Mori M and Doki Y
  • Organizer: AACR 101nd Annual Meeting
  • Place of Presentation: ワシントン
• [Presentation] MUC1, remodeled to express α-gal epitopes immune-based therapy can elicitboth significant prolonged survival and effective antibody production against multiple tumor-associated antigens (2010)
  • Author(s): Tanemura M, Deguchi T, Miyoshi E, Nagano H, Ohmura Y, Machida T, Wada H, Kobayashi S, Marubash S, Eguchi H, Takeda Y, Ito T, Mori M, Doki Y
  • Organizer: AACR 101nd Annual Meeting
  • Place of Presentation: ワシントン(アメリカ)
• [Presentation] 次世代型抗体医薬(ポテリジエント抗体)の創薬を目的とした糖鎖改変膵癌ワクチン療法の研究開発 (2010)
  • Author(s): 種村匡弘、永野浩昭、出口貴司、三善英知、大村仁昭、小林省吾、丸橋繁、江口英利、武田裕、伊藤壽記、森正樹、土岐祐一郎
  • Organizer: 110回日本外科学会定期学術総会
  • Place of Presentation: 名古屋
• [Presentation] 癌幹細胞を標的とした糖鎖改変膵癌ワクチン療法の研究開発 (2010)
  • Author(s): 種村匡弘、出口貴司、永野浩昭、三善英知、大村仁昭、町田智彦、和田浩志、小林省吾、丸橋繁、江口英利、武田裕、伊藤壽記、森正樹、土岐祐一郎
  • Organizer: 65回日本消化器外科学会総会
  • Place of Presentation: 山口
• [Book] レジデントのための消化器外科診療マニュアル (2012)
  • Author(s): 種村匡弘
  • Total Pages: 459
  • Publisher: 医学書院
• [Patent(Industrial Property Rights)] 膵島の分離方法および膵島組織を保護するための保護液 (2010)
  • Inventor(s): 種村匡弘
  • Industrial Property Rights Holder: 大塚製薬工場
  • Industrial Property Number: 2010-159053
  • Filing Date: 2010-07-13
  • Overseas
• [Patent(Industrial Property Rights)] 膵島と脂肪組織由来幹細胞を利用した膵島移植 (2010)
  • Inventor(s): 種村匡弘
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Number: 2010-177993
  • Filing Date: 2010-08-06
  • Overseas
• [Patent(Industrial Property Rights)] 膵島移植時の膵島生着率を高める膵島移植の生着改善剤、膵島移植用生物製剤、及び膵島移植用キット (2010)
  • Inventor(s): 種村匡弘
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Number: 2010-177993
  • Filing Date: 2010-08-06