| Project/Area Number |
22591522
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
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| Research Institution | University of Occupational and Environmental Health, Japan (2012)
Kyushu University (2010-2011) |
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Principal Investigator |
SATO Norihiro 産業医科大学, 医学部, 助教 (20423527)
|
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Masao 九州大学, 医学研究院, 教授 (30163570)
TOMINAGA Yohei 九州大学, 医学研究院, 特任講師 (90304823)
TAKAHATA Shunichi 九州大学, 大学病院, 助教 (50437779)
TSUTSUMI Kosuke 九州大学, 大学病院, 医員 (00467937)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 膵癌 / 癌幹細胞 / 幹細胞 / メチレーション |
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| Research Abstract |
The aim of thisstudy was to investigate the epigenetic regulation of genes related to the phenotype of pancreatic cancer stem cells. First, we planned to purify pancreaticcancer stem cellpopulation by sorting cellsusing specific cellsurface markers. Then, we used a genome-wide apProach to identify DNA nlethylation nlarkers in the subpopulation of pancreatic cancer stem cells. We already have a list of genes that may be regulated primarily by DNA methylation in pancreatic cancer stem cell population. Finally, we are planning to validate these DNA methylation markers identified through the genome-wide approach and to further investigate the functional relevance of each DNA marker.
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