Evaluating of a new role of mesenchymal cells for immunity in pancreatic cancer and new standard for treatment of pancreatic cancer by using the immunity
| Project/Area Number |
22591523
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYASAKA Yoshihiro 九州大学, 医学研究院, 共同研究員 (40507795)
MIZUMOTO Kazuhiro 九州大学, 大学病院, 准教授 (90253418)
MANABE Tatsuya 九州大学, 医学研究院, 助教 (60546464)
TAKAHATA Shuniti 九州大学, 大学病院, 助教 (50437779)
OHUCHIDA Kenoki 九州大学, 先端医療イノベーションセンター, 講師 (20452708)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 膵癌 / 腫瘍免疫 / 間質細胞 / 癌間質相互作用 / 膵星細胞 / マクロファージ |
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| Research Abstract |
In pancreatic stellate cells (PSCs), we revealed that some subtypes of Toll LikeReceptor were found. Moreover, in the mRNA analysis for mRNA derived from a pancreatic cancer bulk organization, it became a bad prognosis in the FAS high quantity group, when the postoperative adjunct therapy was not being performed,. Furthermore, we revealed that PSCs subpopulation which expressed CD10 antigen, which shows specialization of a lymphocyte, has contributed to the malignant behaviors of a tumor. This evaluation for PSCs subtyping further progressed and found out a possibility that CD271 expression was related to a resistance factor to cancer cells, and a possibility that CD146 expression had controlled invasion of cancer cells. Moreover, macrophage preparative isolation from a tumor was performed by using magnetic-separation equipment, and it has expected to progress to the control mechanism elucidation of a cancer cell and stroma targetingspecific new medical treatment by the macrophages and mesenchymal cells in the future
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] CD271 subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells2012
Author(s)
Kenji Fujiwara, Kenoki Ohuchida, KazuhiroMizumoto, Koji Shindo, Daiki Eguchi,Shingo Kozono, Naoki Ikenaga, Takao Ohtsuka, Shunichi Takahata, Shinichi Aishima, Masao Tanaka
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Journal Title
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Peer Reviewed
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[Presentation] CD271+ pancreatic stellate cells are correlated with prognosis of patients with pancreatic cancer and regulated by interaction2012
Author(s)
Kenji Fujiwara, Kenoki Ohuchida, Koji Shindo, Shingo Kozono, Naoki Ikenaga, LinCui, Shinichi Aishima, Masafumi Nakamura, Kazuhiro Mizumoto, Yoshinao Oda, Masao Tanaka
Organizer
cancer cells International Symposium on Pancreas Cancer 2012 in Kyoto
Place of Presentation
京都
Year and Date
2012-10-06
Related Report
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[Presentation] 膵癌におけるCD271陽性膵星細胞の意義2012
Author(s)
藤原謙次, 大内田研宙, 進藤幸治, 赤川進, 江口大樹, 小薗真吾, 池永直樹, 崔林, 相島慎一, 大塚隆生, 高畑俊一, 水元一博, 小田義直, 田中雅夫
Organizer
第112回日本外科学会定期学術集会
Place of Presentation
千葉
Year and Date
2012-04-13
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