| Project/Area Number |
22591529
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
TANI Masaji 和歌山県立医科大学, 医学部, 准教授 (60236677)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190)
KAWAI Manabu 和歌山県立医科大学, 医学部, 講師 (40398459)
HIRONO Seiko 和歌山県立医科大学, 医学部, 助教 (60468288)
MIYAZAWA Motoki 和歌山県立医科大学, 医学部, 学内助教 (90549734)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 膵臓外科学 / 膵癌 / MPF / mesothelin / MPA |
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| Research Abstract |
We performed immune-chemical staining for the pancreatic cancer tissues. All of invasive pancreatic cancer cells expressed mesothelin, and 7 of 9 IPMN-derived pancreatic cancer cells also expressed mesothelin. In addition, the front of IPMN-derived cancer was demonstrated that mesothelin expressed strongly by immune-chemical staining. However, there was no MPF-positive cells. We concluded that it is necessary to consider the mechanism of mesothelin.
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