| Project/Area Number |
22591530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Masakazu 東京女子医科大学, 医学部, 教授 (60220498)
NAKAYAMA Masamiti 東京女子医科大学, 医学部, 講師 (00338980)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
TAKEUCHI Kaoru 筑波大学, 医学医療系, 准教授 (00192162)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肝内胆管癌 / 胆嚢癌 / 糖鎖医学 / 糖転移酵素 / 分子標的治療 / 悪性挙動 / 糖鎖分子 / 標的治療 |
|---|
| Research Abstract |
It is a well-known fact that oligosaccharide structures are dramatically changed in carcinogenesis including malignant transformation.N-Acetylglucosaminyltransferase V (GnT-V) enhances the malignant behaviors of carcinoma cells such as proliferation, invasion and metastasis. In this study, the immunohistochemical expression of GnT-V was studied in the tissue sections of gallbladder carcinoma and those of intrahepatic cholangiocarcinoma. The results revealed that in gallbladder carcinoma, the post-surgical prognosis was significantly poorer in the cases of positive staining than in those of negative staining and, moreover, that the post-surgical recurrence rate tended to be higher in the former than in the latter. However, in cholangiocarcinoma, the immunohistochemical expression of GnT-V did not give any clinicopathological significance. A molecular-targeting therapy against GnT-V may be useful in the treatment of biliary tarct cancers
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