Exploration of carbohydrate molecules that regulate malignant behaviors of intrahepatic cholangiocarcinoma, and application for the development of novel molecular-targeting therapy
| Project/Area Number |
22591530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Masakazu 東京女子医科大学, 医学部, 教授 (60220498)
NAKAYAMA Masamiti 東京女子医科大学, 医学部, 講師 (00338980)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
TAKEUCHI Kaoru 筑波大学, 医学医療系, 准教授 (00192162)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肝内胆管癌 / 胆嚢癌 / 糖鎖医学 / 糖転移酵素 / 分子標的治療 / 悪性挙動 / 糖鎖分子 / 標的治療 |
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| Research Abstract |
It is a well-known fact that oligosaccharide structures are dramatically changed in carcinogenesis including malignant transformation.N-Acetylglucosaminyltransferase V (GnT-V) enhances the malignant behaviors of carcinoma cells such as proliferation, invasion and metastasis. In this study, the immunohistochemical expression of GnT-V was studied in the tissue sections of gallbladder carcinoma and those of intrahepatic cholangiocarcinoma. The results revealed that in gallbladder carcinoma, the post-surgical prognosis was significantly poorer in the cases of positive staining than in those of negative staining and, moreover, that the post-surgical recurrence rate tended to be higher in the former than in the latter. However, in cholangiocarcinoma, the immunohistochemical expression of GnT-V did not give any clinicopathological significance. A molecular-targeting therapy against GnT-V may be useful in the treatment of biliary tarct cancers
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder2013
Author(s)
Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J.
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Journal Title
J Gastroenterol
Volume: (in press)
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[Journal Article] Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells2011
Author(s)
Sugiyama H, Onuki K, Ishige K, Baba N, Ueda T, Matsuda S, Takeuchi K, OnoderaM, Nakanuma Y, Yamato M, Yamamoto M, Hyodo I, Shoda J.
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Journal Title
J Gastroenterol
Volume: 46
Pages: 779-789
NAID
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[Journal Article] Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas2011
Author(s)
Furukawa T, Hatori T, Fujita I, Yamamoto M, Kobayashi M, Ohike N, Morohoshi T, Egawa S, Unno M, Takao S, Osako M, Yonezawa S, Mino-Kenudson M, Lauwers GY, Yamaguchi H, Ban S, Shimizu M.
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Journal Title
Gut
Volume: 60
Pages: 509-16
Related Report
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[Journal Article] Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells.2011
Author(s)
Sugiyama H, Onuki K, Ishige K, Baba N, Ueda T, Matsuda S, Takeuchi K, Onodera M, Nakanuma Y, Yamato M, Yamamoto M, Hyodo I, Shoda J.
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Journal Title
J Gastroenterol
Volume: 46
Issue: 6
Pages: 779-789
DOI
NAID
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Peer Reviewed
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[Journal Article] WFA-positive sialylated MUC1 is a high-sensitivity biliary marker for intrahepatic cholangiocarcinoma2010
Author(s)
Matsuda A, Kuno A, Kawamoto K, Matsuzaki H, Irimura T, Ikehara Y, Zen Y, NakanumaY, Yamamoto M, Ohkohchi N, Shoda J, Hirabayashi J, Narimatsu H.
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Journal Title
Hepatology
Volume: 52
Pages: 174-182
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[Presentation] 左三区域切除兼肝外胆道切除にて切除し得た Binf 陽性胆嚢癌の1例2012
Author(s)
樋口亮太,梶山英樹,谷澤武久,小貫建一郎,植村修一郎,濱野美枝,竹下信啓,古川 徹,太田岳洋,新井田達雄,山本雅一
Organizer
第48回日本胆道学会学術集会
Place of Presentation
東京
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