M0LECULAR MECHANISIM AND BIOMARKER OF AORTIC DISSECTION
| Project/Area Number |
22591535
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SATO Akira 筑波大学, 医学医療系, 准教授 (30528469)
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| Co-Investigator(Kenkyū-buntansha) |
AONUMA Kazutaka 筑波大学, 医学医療系, 教授 (10375488)
IMANAKA Kyoko 三重大学, 医学系研究科, 准教授 (00242967)
YOSHIMURA Koichi 山口大学, 医学系研究科, 准教授 (00322248)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Taizo 筑波大学, 附属病院, 病院講師 (00636508)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | B型大動脈解離 / テネイシンCノックアウトマウス / バイオマーカー / トランクスクリプトーム解析 |
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| Research Abstract |
We evaluated 42 patients with type B acute aortic dissection (AD), andserum TN-C levels significantly increased at 7 days and then gradually decreased to normal range at 28 days. Serum TN-C levels at 7 days correlated positively with peak C-reactive protein levels, FDP levels, D-dimer levels, and maximum aortic diameter at the dissection level on admission. Serum TN-C levels of 3 dead patients on admission were significantly higher than those of surviving patients. Serum TN-C levels were significantly elevated during acute stage and might be a novel biomarker to predict patient prognosis of type B acute AD.In mouse model, TN-C was highly expressed in the medial layer of the dissected aortic wall, andwas concordant with the area of the vascular smooth muscle cells (VSMCs) stained by α-SMA. In the TN-C reporter mouse knock-in with LacZ, the medial layer of the dissected aortic wall was stained by the β-gal, and furthermore αSMA-positive cells were also positive in β-gal. We found that the producing cells of TN-C were VSMCs in the dissected aortic wall.
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Report
(4 results)
Research Products
(4 results)
