MicroRNAs Analysis for Investigation of the Causes in Human Atrium Electrical Remodeling

• Project/Area Number: 22591547
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Oita University
• Principal Investigator: IWATA Eriko 大分大学, 医学部, 医員 (70457604)
• Co-Investigator(Kenkyū-buntansha): ONO Katishige 大分大学, 医学部病態生理学講座, 教授 (40253778) ; MORISHIMA Masaki 大分大学, 医学部病態生理学講座, 助教 (40437934)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 循環器 / 不性脈 / イオンチャネル / マイクロ RNA / 心房細動 / 体外循環 / マイクロRNA / 不整脈 / 対外循環

Research Abstract

Even though atrial fibrillation is the most commonly encountered clinical arrhythmia,the therapeutic strategy has not been established. Atrial tissue was obtained from patients undergoing cardiovascular surgery using extracorporial circulation. W e identified some ion channels and microRNAs that were down-regulated or up-regulated in atrial fibrillation patients, and suggested it’ s relation to ion channel remodeling and the possibility of therapeutic application.