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The strategy of modulation for epigenetics against ischemic spinal cord injury

Research Project

Project/Area Number 22591548
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionUniversity of the Ryukyus

Principal Investigator

SAIKAWA Satoko  琉球大学, 大学院・医学研究科, 助教 (20404569)

Co-Investigator(Kenkyū-buntansha) KAKINOHANA Manabu  琉球大学, 大学院・医学研究科, 准教授 (20274897)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords硫化水素 / 遅発性対麻痺 / 脊髄虚血 / アポトーシス / 遅発性麻痺 / エピジェネティクス / 神経変性 / 虚血性脊髄障害 / 対麻痺 / ヒストン脱アセチル化酵素 / 脊髄運動神経細胞
Research Abstract

We investigated whether inhibition of histon-deacetylation (HDAC) can exert neuroprotective effect against delayed paraplegia after spinal cord ische mia in mice. Treatment groups were divided into 3 groups in corresponding to duration of HDAC treatment (7 days before, 3 days before, and 1 day before spinal cord ischemia). Saline treatment was defined as control group. As a result from our experiments, any animal treated with inhibition of HDAC could not show significantly improve neurological outcome in comparison with control group. Histopathological and immunohistopathological analysis also failed to show any differences among all groups. According to our data, modulation of HDAC is unlikely to be associated with delayed neurological degeneration in spinal ventral horn in mice spinal cord ischemic model.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Delayed paraplegia after spinal cord ischemic injuries requires caspase-3 activation in mice2011

    • Author(s)
      M Kakinohana(研究分担者), K Kida, S Minamishima, DN Atochin, PL Huang, M Kaneki, F Ichinose
    • Journal Title

      Stroke

      Volume: 42 Pages: 2302-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice2011

    • Author(s)
      Kakinohana M, et al
    • Journal Title

      Stroke

      Volume: 42 Pages: 2302-2307

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遅発性対麻痺にカスパーゼ3は必須である2011

    • Author(s)
      垣花学
    • Organizer
      第38回日本集中治療医学会学術大会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2011-02-25
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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