Study of elastic fiber dysplasia on aortic aneurysm outbreak aiming at tailor-made medicine.

• Project/Area Number: 22591549
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Yokohama City University
• Principal Investigator: SUZUKI Shinichi 横浜市立大学, 医学部, 准教授 (90285130)
• Co-Investigator(Kenkyū-buntansha): MASUDA Munetaka 横浜市立大学, 医学研究科, 教授 (10190365) ; IMOTO Kiyotaka 横浜市立大学, 市民総合医療センター, 教授 (40203335) ; UCHIDA Keiji 横浜市立大学, 市民総合医療センター, 准教授 (50275062) ; YOKOYAMA Utako 横浜市立大学, 医学部, 講師 (70404994)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 大血管外科学 / オーダーメイド医療 / 大動脈瘤 / 弾性繊維形成

Research Abstract

Aortic aneurysm is a common but life-threatening disease among the elderly, for which no effective medical therapy is currently available. Activation of prostaglandin E2 (PGE2) is known to increase the expression of matrix metalloproteinase (MMP) and may thus exacerbate abdominal aortic aneurism (AAA) formation. An EP4 antagonist that prevents the activation of MMP and thereby the degeneration of aortic elastic fiber may serve as a new strategy for medical treatment of AAA.

Research Products

• [Journal Article] Inhibition of EP4 signaling attenuates aortic aneurysm formation (2012)
  • Author(s): Yokoyama U, Ishiwata R, Jin M-H, Kata Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fujita T, Okumura S, Sato M, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, Ishikawa Y
  • Journal Title: PLoS One Volume: 7(5)
  • Peer Reviewed
• [Journal Article] Inhibition of EP4 signaling attenuates aortic aneurysm formation. (2012)
  • Author(s): Yokoyama U
  • Journal Title: PLoS One Volume: -
  • Peer Reviewed
• [Journal Article] Inhibition of EP4 signaling attenuates aortic aneurysm formation (2012)
  • Author(s): Yokoyama U
  • Journal Title: PLoS One
  • Peer Reviewed
• [Presentation] Gene analysis in patients with non-syndromic aortic aneurysm and dissection (2013)
  • Author(s): Suzuki S, Masuda M, Goda M, Katayama Y, Sakai H, Matsumoto N
  • Organizer: The Houston Aortic Symposium. Frontiers in Cardiovascular Diseases. The Sixth in the Series.
  • Place of Presentation: Houston, USA
  • Year and Date: 2013-03-21
• [Presentation] The Pole of Prostaglandin E(PGE) Recepter EP4 in Aortic Aneurysm Formation (2012)
  • Author(s): Katayama Y, Yokoyama U, Nemoto H, Kasama K, Suzuki S, Isomatsu Y, Uchida K, Imoto K, Ishikawa Y, Masuda M
  • Organizer: 2012 AATS NY aortic symposium
  • Place of Presentation: New York, USA
  • Year and Date: 2012-04-27
• [Presentation] B型急性大動脈解離に対する治療の進歩 (2012)
  • Author(s): 内田敬二,井元清隆,安恒亨,南智行,長知樹,梅田悦嗣,神尾一樹,稲福賢司,鈴木伸一,益田宗孝
  • Organizer: 第42回日本心臓血管外科学会(パネルディスカッション)
  • Place of Presentation: 秋田キャッスルホテル(秋田県)
  • Year and Date: 2012-04-18
• [Presentation] 大動脈瘤形成におけるプロスタグランジンE2受容体EP4の役割の検討 (2012)
  • Author(s): 片山雄三、横山詩子、根元寛子、笠間啓一郎、鈴木伸一、磯松尚幸、内田敬二、井元清隆、石川義弘、益田宗孝
  • Organizer: 第42回日本心臓血管外科学会
  • Place of Presentation: 秋田キャッスルホテル(秋田県)
  • Year and Date: 2012-04-18
• [Presentation] 非症候性大動脈疾患における遺伝子解析 (2012)
  • Author(s): 鈴木伸一、益田宗孝、磯松尚幸、笠間啓一郎、片山雄三、根元寛子、井元清隆、内田敬二、南智行、堺温哉, 松本直通
  • Organizer: 第42回日本心臓血管外科学会
  • Place of Presentation: 秋田キャッスルホテル(秋田県)
  • Year and Date: 2012-04-18