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Study of elastic fiber dysplasia on aortic aneurysm outbreak aiming at tailor-made medicine.

Research Project

Project/Area Number 22591549
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionYokohama City University

Principal Investigator

SUZUKI Shinichi  横浜市立大学, 医学部, 准教授 (90285130)

Co-Investigator(Kenkyū-buntansha) MASUDA Munetaka  横浜市立大学, 医学研究科, 教授 (10190365)
IMOTO Kiyotaka  横浜市立大学, 市民総合医療センター, 教授 (40203335)
UCHIDA Keiji  横浜市立大学, 市民総合医療センター, 准教授 (50275062)
YOKOYAMA Utako  横浜市立大学, 医学部, 講師 (70404994)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords大血管外科学 / オーダーメイド医療 / 大動脈瘤 / 弾性繊維形成
Research Abstract

Aortic aneurysm is a common but life-threatening disease among the elderly, for which no effective medical therapy is currently available. Activation of prostaglandin E2 (PGE2) is known to increase the expression of matrix metalloproteinase (MMP) and may thus exacerbate abdominal aortic aneurism (AAA) formation. An EP4 antagonist that prevents the activation of MMP and thereby the degeneration of aortic elastic fiber may serve as a new strategy for medical treatment of AAA.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Inhibition of EP4 signaling attenuates aortic aneurysm formation2012

    • Author(s)
      Yokoyama U, Ishiwata R, Jin M-H, Kata Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fujita T, Okumura S, Sato M, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, Ishikawa Y
    • Journal Title

      PLoS One

      Volume: 7(5)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of EP4 signaling attenuates aortic aneurysm formation.2012

    • Author(s)
      Yokoyama U
    • Journal Title

      PLoS One

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of EP4 signaling attenuates aortic aneurysm formation2012

    • Author(s)
      Yokoyama U
    • Journal Title

      PLoS One

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Gene analysis in patients with non-syndromic aortic aneurysm and dissection2013

    • Author(s)
      Suzuki S, Masuda M, Goda M, Katayama Y, Sakai H, Matsumoto N
    • Organizer
      The Houston Aortic Symposium. Frontiers in Cardiovascular Diseases. The Sixth in the Series.
    • Place of Presentation
      Houston, USA
    • Year and Date
      2013-03-21
    • Related Report
      2012 Final Research Report
  • [Presentation] The Pole of Prostaglandin E(PGE) Recepter EP4 in Aortic Aneurysm Formation2012

    • Author(s)
      Katayama Y, Yokoyama U, Nemoto H, Kasama K, Suzuki S, Isomatsu Y, Uchida K, Imoto K, Ishikawa Y, Masuda M
    • Organizer
      2012 AATS NY aortic symposium
    • Place of Presentation
      New York, USA
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] B型急性大動脈解離に対する治療の進歩2012

    • Author(s)
      内田敬二,井元清隆,安恒亨,南智行,長知樹,梅田悦嗣,神尾一樹,稲福賢司,鈴木伸一,益田宗孝
    • Organizer
      第42回日本心臓血管外科学会(パネルディスカッション)
    • Place of Presentation
      秋田キャッスルホテル(秋田県)
    • Year and Date
      2012-04-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 大動脈瘤形成におけるプロスタグランジンE2受容体EP4の役割の検討2012

    • Author(s)
      片山雄三、横山詩子、根元寛子、笠間啓一郎、鈴木伸一、磯松尚幸、内田敬二、井元清隆、石川義弘、益田宗孝
    • Organizer
      第42回日本心臓血管外科学会
    • Place of Presentation
      秋田キャッスルホテル(秋田県)
    • Year and Date
      2012-04-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 非症候性大動脈疾患における遺伝子解析2012

    • Author(s)
      鈴木伸一、益田宗孝、磯松尚幸、笠間啓一郎、片山雄三、根元寛子、井元清隆、内田敬二、南智行、堺温哉, 松本直通
    • Organizer
      第42回日本心臓血管外科学会
    • Place of Presentation
      秋田キャッスルホテル(秋田県)
    • Year and Date
      2012-04-18
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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