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Anti-proliferative miRNA expression in squamous cell carcinoma of the lung: Pursue for the common therapeutic targets of the tobacco-related cancer

Research Project

Project/Area Number 22591559
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionChiba Cancer Center (Research Institute) (2012)
Chiba University (2010-2011)

Principal Investigator

MORIYA Yasumitsu  千葉県がんセンター(研究所), その他部局等, 主任医長 (90375692)

Co-Investigator(Kenkyū-buntansha) YOSHINO Ichiro  千葉大学, 大学院・医学研究院, 教授 (40281547)
SEKI Naohiko  千葉大学, 大学院・医学研究院, 准教授 (50345013)
岡本 龍郎  千葉大学, 大学院・医学研究院, 助教 (80568626)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肺癌 / マイクロアレイ / ゲノム / マイクロRNA / 遺伝子 / 外科 / 癌
Research Abstract

In tobacco-related cancers including lung squamous cell carcinoma, disorder of anti-proliferative miRNA expression may be involved in the pathogenesis, and one of the miRNAs is likely to be a candidate of molecular targets. Now the referred miRNA is further analyzed for the expression status in a large series of clinical lung cancers.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results)

  • [Journal Article] Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma2012

    • Author(s)
      Moriya Y, Yoshino I, Seki N et al.
    • Journal Title

      Journal of Human Genetics

      Volume: 57 Pages: 38-45

    • NAID

      10030662337

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma2012

    • Author(s)
      Yasumitsu Moriya
    • Journal Title

      Journal of Human Genetics

      Volume: 67 Issue: 1 Pages: 38-45

    • DOI

      10.1038/jhg.2011.126

    • NAID

      10030662337

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Anti-proliferative microRNA expression in squamous cell ca rcinoma of the lung2012

    • Author(s)
      Moriya Y et al
    • Organizer
      5^<th> Asia Pacific Lung Cancer Conference
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺扁平上皮癌におけるmicroRNA-133aの機能解析および標的遺伝子の探索2012

    • Author(s)
      守屋康充、他
    • Organizer
      第ll2回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺扁平上皮癌におけるmicroRNA-133aの機能解析および標的遺伝子の探索2012

    • Author(s)
      守屋康充
    • Organizer
      第112回 日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺癌切除検体におけるmiRNA-133aの発現と標的遺伝子の解析2012

    • Author(s)
      守屋康充
    • Organizer
      第29回 日本呼吸器外科学会総会
    • Place of Presentation
      秋田県民会館(秋田)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺癌における癌抑制microRNA-133aの機能解析2012

    • Author(s)
      守屋康充
    • Organizer
      第53回 日本肺癌学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Anti-proliferative microRNA expression in squamous cell carcinoma of the lung2012

    • Author(s)
      Yasumitsu Moriya
    • Organizer
      5^<th> Asia Pacific Lung Cancer Conference
    • Place of Presentation
      ヒルトン福岡シーボーグ(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺扁平上皮癌における増殖抑制性microRNAの同定:喫煙関連癌における分子標的の解明2011

    • Author(s)
      守屋康充、他
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺扁平上皮癌における増殖抑制性miRNAの同定:喫煙関連癌における分子標的の解明2011

    • Author(s)
      守屋康充
    • Organizer
      第111回 日本外科学会定期学術集会(国際シンポジウム)
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロRNA発現プロファイルに基づく肺扁平上皮癌の新たな治療標的の探索2010

    • Author(s)
      守屋康充
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of tumor suppressive miRNAs by miRNA expression signature in lung squamous cell carcinoma2010

    • Author(s)
      守屋康充
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロRNA発現プロファイルに基づく肺扁平上皮癌の新たな治療標的の探索2010

    • Author(s)
      守屋康充、他
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of tumorsuppressive miRNAs by miRNA expression signature in squamous cell carcinoma2010

    • Author(s)
      守屋康充、他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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